1. Changes of immunoglobulins and CD series in patients with Graves′ orbitopathy treated with high-dose methylprednisolone
Abudukerimu BUATIKAMU ; Qin LI ; Ningjian WANG ; Fangzhen XIA ; Yi CHEN ; Xiaoman CHEN ; Chunfang ZHU ; Jie QIAO ; Fanfan ZHU ; Yingli LU
Chinese Journal of Endocrinology and Metabolism 2019;35(9):756-760
Objective:
To study the effect of high-dose methylprednisolone intravenous pulse therapy on immunoglobulins and CD series in patients with active moderate-to-severe Graves′ orbitopathy.
Methods:
Twenty-seven patients with active moderate-to-severe Graves′ orbitopathy were enrolled in this study. All the patients received iv methylprednisolone pulse therapy for 12 weeks according to the 2016 European Thyroid Association/European Group on Graves′Orbitopathy(EUGOGO) Guidelines. Serum thyroidal autoantibodies, such as thyroid-stimulating hormone receptor antibody (TRAb), anti-thyroperoxidase antibody (TPOAb), and serum immunoglobulins, such as IgG, IgE, IgA, IgM were evaluated at the baseline, at the end of 4th and 12th week. Percentages of CD3+ T cells, CD4+ T cells, CD8+ T cells and CD19+ B cells, CD16+ or CD56+ NK cells were also evaluated at each time point.
Results:
TRAb, TPOA and IgE, IgG, IgA were significantly decreased both after 4th week and after 12th week (all
2. The use of antidiabetic medications in community-dwelling diabetic patients in Shanghai in 2018
Xiaoman CHEN ; Ningjian WANG ; Yi CHEN ; Chunfang ZHU ; Chenyu CAO ; Abudukerimu BUATIKAMU ; Wen ZHANG ; Yingli LU
Chinese Journal of Endocrinology and Metabolism 2019;35(11):955-961
Objective:
To investigate the use of diabetes medications and their effects on the community diabetic patients in Shanghai, China, and provide the evidence for the use of antidiabetic drugs in diabetic patients in the region.
Methods:
The data were from a database of a 2018 Survey on Community Diabetes Mellitus in Shanghai, China. There were 4 612 subjects included in this cross-sectional study in 2018. According to the use of antidiabetic drugs, the population was divided into untreated group, single drug group, double drugs combination group and multi-drugs combination group, to compare the fasting blood glucose, glycosylated hemoglobin, BMI and prevalence of diabetic complications in different groups.
Results:
About 70.9% of the 4 612 patients used hypoglycemic agents, 34.8% used metformin, 35.1% used sulfonylureas, 22.9% used alpha glycosidase inhibitors, and 13.8% used insulin. The prevalence of diabetic nephropathy, retinopathy, neuropathy, stroke, and diabetic foot was higher in the combination than in the untreated and single-drug users (