Objective To investigate the prognostic value of fibrinogen to albumin ratio (FAR) com-bined with triglyceride glucose product (TyG) on long-term adverse events in the patients with acute myocar-dial infarction.Methods A total of 325 patients with acute myocardial infarction treated by percutaneous cor-onary intervention (PCI) in the Second People's Hospital of Kashi Prefecture from January 2019 to January 2020 were selected as the study subjects.The patients were followed up for 1 year and divided into the study group (n=30) and control group (n=295) according to whether or not the major adverse cardiovascular e-vents (MACE) occurring.The medical case records of the patients such as blood lipid indexes and cardiac function indexes were recorded in detail.The multivariate Cox regression was used to analyze the risk factors affecting MACE occurrence in the patients with acute myocardial infarction.The receiver operating character-istic (ROC) curve was used to study the predictive value of FAR and TyG for the occurrence of MACE in the patients with acute myocardial infarction.Results The levels of FAR and TyG in the study group were higher than those in the control group,and the difference was statistically significant (P<0.05).The multivariate Cox regression analysis results showed that the FAR increase and TyG score increase were the independent risk factors for MACE occurrence in the patients with acute myocardial infarction (P<0.05).The ROC curve results showed that the prognosis in the patients with TyG≥7.943 and FAR≥0.086 was poorer than those with TyG<7.943 and FAR≥0.086,TyG≥7.943 and FAR<0.086,and TyG<7.943 and FAR<0.086,and the differences were statistically significant (P<0.05).Conclusion The increase of peripheral blood FAR and TyG is closely related to the prognosis of acute myocardial infarction.Early combined detection of FAR and TyG has the guidance significance in evaluating the prognosis of the patients with acute myocardial infarction.