The study was carried out at Hung Vuong Hospital in 1998 to compare vaginal misoprostol with extra-amniotic balloon to induce abortion in second trimester. Patients were received either 800mcg misoprostol vaginally (n=87) or 500ml of 0.9% NaCl solution inserted into extra-amniotic cavity (n= 93) for induced abortion. Vaginal misoprostol was repeated 24-hourly for maximum of three times. The abortion rates were 98.9% and 96.8% for misoprostol and balloon group, respectively. A second attempt was need in approximate one third of patients in misoprostol group and 10% in balloon group. Side effects of misoprostol were mild and transient. Vaginal misoprostol is as effective as balloon for induced abortion in second trimester. Misoprostol is cheap and easily stored and used. Vaginal misoprostol could be considered as an alternative to balloon for induced abortion
Abortion, Therapeutic ; Misoprostol ; Abortion, Induced

No abstract available.
Abortion, Therapeutic* ; Female* ; Humans ; Pregnancy ; Sterilization, Reproductive*

In the case of pregnancy complicated by intrauterine device, complications such as ectopic pregnancy, septic abortion, preterm delivery are increased significantly. Especially in relation to intrauterine pregnancy, IUD should be removed to prevent complication. But when the tail is missed, therapeutic abortion has been done as an alternative method conventionally. Recently we experienced a case of hysteroscopic removal of IUD complicated by intrauterine pregnancy of 9th week without any harm to the G -sac or embryo. And she delivered healthy girl weighing 2950 gm. So we report this case with the review of articles related.
Abortion, Septic ; Abortion, Therapeutic ; Embryonic Structures ; Female ; Humans ; Intrauterine Devices* ; Pregnancy* ; Pregnancy, Ectopic

Holoprosencephaly is a rare complex cerebral anomaly produced by a failure of cleavage of the prosencephalon. The association of brain anomalies and facial dysmorphism is a typical finding. There are three types(alobar, semilobar, and lobar) of holoprosencephaly. Among these the alobar type has the worst prognosis. The early antenatal diagnosis of the holoprosencephaly is very important determinant for initiating the therapeutic abortion. We report 3 cases of alobar holoprosencephaly with the brief review of the literature.
Abortion, Therapeutic ; Brain ; Female ; Holoprosencephaly* ; Pregnancy ; Prenatal Diagnosis ; Prognosis ; Prosencephalon

Clinical efficacy of tokishakuyakusan against immunologic recurrent abortion was evaluated using methods of diagnostic statistics. The subjects of this study were 38 women with recurrent abortion who had experienced a spontaneous abortion during their first trimester (within 12 weeks of pregnancy) twice, and who took tokishakuyakusan (extract granules) after development of their third pregnancy, but experienced spontaneous abortion again during their first trimester, with the karyotype of the aborted fetus being rated as 46, XX or 46, XY. The control group consisted of 244 women who had experienced 3 or more spontaneous abortions during their first trimester of pregnancy. The detection rates of autoimmune disorders and alloimmune disorders were compared statistically between the two groups. Neither the detection rate of autoimmune recurrent abortion nor the detection rate of alloimmune recurrent abortion differed significantly between the two groups, suggesting that tokishakuyakusan is not clinically effective against immunologic recurrent abortion. Tokishakuyakusan is estimated to prevent abortion caused by compromised luteal insufficiency of the uterus. Thus, saireito seems to provide a more rational means of Kampo therapy for immunologic recurrent abortion.
Unspecified Abortion ; immunologic ; tokishakuyakusan ; Therapeutic procedure ; Pregnancy Trimester, First

Early pregnancy factor(EPF) is believed to be a pregnancy-associated immunosuppressivepolypeptide which might inhibit the function of maternal lymphocyte during pregnancy. Thephysiological role of EPF in human pregnancy has remained controversal. The purposes of thisstudy are to investigate whether EPF determinations have prognostic value in women withthreatened abortion, and to evaluate usefulness in diagnosing early pregnancy and in predictingthe outcome of embryo transferred in vitro fertilization-embryo transfer(IVF-ET) program.EPF activity was measured by a recently developed, micro rosette inhibition test in sera from76 normal pregnant women, 25 normal healthy women with tubal ligation, 58 women withtherapeutic surgical abortion(n=18) or threatened abortion(n=40) and 29 IVF-ET patients. Rosetteinhibition titer>or=3 was defined as an index for the presence of EPF activity. EPF activity wasundetectable in sera of normal healthy women with tubal ligation and in sera taken before ET.In normal pregnancy EPF was detected in 88~92% of sera during the first and second trimesterand almost disappeared in the third trimester. Surgical therapeutic abortion in the firsttrimester lead to disappearance of EPF activity in 92.3% of cases second day after procedure.The sensitivity of the EPF assay in predicting the outcome in pregnant women with threatenedabortion was 88.0% and the specificity was found to be 86.7%. In patients who became pregnantafter IVF-ET procedure EPF activity was detected in 85.7% of sera on the 5th day andin all sera on the 12th day. In 80.0%(9/13) sera of patients who failed to become pregnant afterET, EPT activity was detected on the 5th day but 17(94.4%) of 18 sera was proved to benegative for EPF activity on the 12th day. These data suggest that EPF assay by micro rosetteinhibition test may be useful in monitoring the embryo after ET, in dignosing early pregnancyand in predicting the outcome in women with threatened abortion.
Abortion, Therapeutic ; Abortion, Threatened* ; Embryonic Structures ; Female ; Humans ; Lymphocytes ; Pregnancy Trimester, Third ; Pregnancy* ; Pregnant Women ; Sensitivity and Specificity ; Sterilization, Tubal

Abortion, Habitual ; drug therapy ; Abortion, Spontaneous ; drug therapy ; Adult ; Aspirin ; therapeutic use ; Female ; Heparin, Low-Molecular-Weight ; therapeutic use ; Humans ; Prednisone ; therapeutic use ; Pregnancy ; Pregnancy Outcome

A case of thanatophoric dwarfism is presented. The previous gestation was polyhydramniotic and aborted spontaneously at 19th week. The aborted fetus showed marked micromelia. Present gestation was also polyhydramniotic and terminated by therapeutic abortion at 31th weeks due to skeletal deformity representing thanatophoric dwarfism. The fetus shows typical characteristics of thanatophoric dwarfism. Grossly the fetus shows marked micromelia, narrowed thorax with relatively normal length of trunk, and enlarged head. In the radiograph the femur shows characteristic ‘ telephone receiver’-like form. And the histological observations shows marked disturbances of the endochondral ossification.
Aborted Fetus ; Abortion, Therapeutic ; Congenital Abnormalities ; Female ; Femur ; Fetus ; Head ; Pregnancy ; Telephone ; Thanatophoric Dysplasia* ; Thorax

At various intervals after first trimester therapeutic abortion, in a total of 1604 cases laparoscopic sterilization procedures were performed at Severance Hospital of Yonsei University Medical Center, Seoul, Korea, from May 1973 to October 1975. A total of 214 women were sterilized immediately after abortion, 359 were sterilized between one and 42 days after abortion and the remaining 1031 women were sterilized 43 or more days after abortion. Electrocoagulation and tubal ring were the two tubal-occlusion techniques used. The findings indicate that patients who underwent the combined abortion-sterilization procedures did not encounter higher rates of technical and/or complications than the other two groups. Only a few patients among the total study subjects had potentially serious complications which neceisstated subsequent laparotomy and hospitalization after sterilization.
Abortion, Therapeutic* ; Adult ; Female ; Human ; Korea ; Postoperative Complications ; Pregnancy ; Pregnancy Trimester, First ; Sterilization, Tubal* ; Time Factors

The efficacy of Saireito (a herbal preparation) against autoimmune recurrent abortion was evaluated clinically and immunologically. Saireito therapy was performed with 87 women having experienced 3 or more recurrent abortions in the early stages of pregnancy (less than 12 weeks gestation), and whose antinuclear antibody (ANA) and anti-cardiolipine antibody (ACA) test results were positive. The effects of this therapy on the percentage of women in whom abortion was successfully prevented (the abortion prevention rate), and on the antibody titer were investigated. Among the 49 women who became pregnant during the study period, the abortion prevention rate was 63.3%, the percentage of ANA positive cases was 65.6%(32/49), the percentage of ACA IgG and/or IgM positive cases (as evaluated by SRL methods) was 65.5%(29/49) and the percentage of both ANA and ACA IgG and /or IgM positive cases was 75.0%(12/49). Although the titer of ANA was not significantly reduced by this therapy, the titer of ACA IgM was reduced significantly.These results suggest that Saireito exerts its efficacy by suppressing humoral immunity through its adjustment of the Th1/Th 2 cytokine balance. This therapy is expected to be effective against ACA-positive recurrent abortion by reducing the effects of ACA. Furthermore, in 2 observed child birth cases whose ACA titer were not decreased by Saireito, different effective mechanisms were speculated; for example, suppression of platelet aggregation via saireito's component herbs (ninjin and bukuryou) similar to the effect seen with low-dose aspirin therapy, or its “risui” effect via its components (bukuryou, soujyutu, takusha and chorei).
Therapeutic procedure ; Unspecified Abortion ; Antinuclear Antibody Assay ; Antibodies ; Immunoglobulin M measurement