1.Impact of glibenclamide versus Insulin on neurological and functional outcomes of hemorrhagic stroke in diabetic patients
Keyvan Ghasami ; Mohammad Reza Rezvanfar ; Fardin Faraji ; Abolfazl Mohammadbeigi ; Mohammad Rafiee
Neurology Asia 2013;18(2):137-141
Background & Objective: Stroke is one of the common leading causes of morbidity and mortality
worldwide. Diabetes is one of the modifi able risk factors of stroke which is related to a higher mortality
and a poorer outcome. We aimed to evaluate the protective effect of Insulin versus glibenclamide on
the improvement of neurological and functional outcomes of hemorrhagic stroke. Methods: The present
single blind clinical trial was conducted on 100 patients with stroke and diabetes who had referred to
Neurology Emergency Department of Vali-e-Asr hospital, Arak, Iran. The patients were categorized
into two groups according to the glucose control treatment before stroke. Without any randomization,
glibenclamide was used in 45 patients, while others (55 ones) received insulin. National Institute of
Health Stroke Scale (NIHSS) and modifi ed Rankin scale (MRS) systems were used for evaluating
the neurological and functional outcomes. Results: Hemiparesis was the most common sign of the
patients. The mean of changes in NIHSS and MRS scores of the two groups were -29.69±21.4 and
-17.24±21, respectively. Although Insulin group had a higher decrease in NIHSS and MRS scores, no
signifi cant difference was found between the two groups. Both treatment methods had a signifi cant
decreasing effect on NIHSS and MRS scores (p<0.001).
Conclusion: Patients treated with both glibenclamide and insulin had similar decrease in their one
week NIHSS and MRS scores with no signifi cant difference in the two treatment groups.
2.Dyslipidemia Prevalence in Iranian Adult Men: The Impact of Population-Based Screening on the Detection of Undiagnosed Patients.
Abolfazl MOHAMMADBEIGI ; Esamil MOSHIRI ; Narges MOHAMMADSALEHI ; Hossein ANSARI ; Ali AHMADI
The World Journal of Men's Health 2015;33(3):167-173
PURPOSE: Dyslipidemia has been established as one of the most important modifiable risk factors for cardiovascular disease. Due to the higher prevalence of dyslipidemia in males, this study aimed to estimate the prevalence of dyslipidemia in Iranian urban men. MATERIALS AND METHODS: A screening program was conducted in 845 Iranian men 25 years of age and older in 2014. A health interview survey was conducted to evaluate the prevalence of self-reported dyslipidemia and to collect demographic data, as well as serum lipid profile screening by a reference laboratory. Lipoprotein levels was categorized based on the Adult Treatment Panel III criteria and the data were analyzed using the chi-square test and analysis of variance. RESULTS: The overall prevalence of dyslipidemia was 51.8%, and the prevalence of various forms of dyslipidemia was as follows: hypercholesterolemia (> or =240 mg/dL), 11.4%; hyper-low-density lipoprotein cholesterol (> or =160 mg/dL), 9.6%; hypertriglyceridemia (> or =200 mg/dL), 25%; and hypo-high-density lipoprotein (HDL) cholesterol (<40 mg/dL), 34.3%. With the exception of hypo-HDL, all forms of dyslipidemia were significantly less common in men over 65 years of age (p<0.05). CONCLUSIONS: The prevalence of hypo-HDL and hypertriglyceridemia was higher than expected in Iranian adult men, with half of men 25 years of age and older affected by at least one form of dyslipidemia. A large gap in primary and secondary care was observed, because nearly 80% of patients with dyslipidemia were unaware of their status. Urgent preventive programs and lifestyle changes are necessary to reduce the prevalence of cardiovascular risk factors.
Adult*
;
Cardiovascular Diseases
;
Cholesterol
;
Dyslipidemias*
;
Humans
;
Hypercholesterolemia
;
Hypertriglyceridemia
;
Life Style
;
Lipoproteins
;
Male
;
Mass Screening*
;
Metabolic Diseases
;
Prevalence*
;
Risk Factors
;
Secondary Care
3.Prevalence of Metabolic Syndrome and Associations with Lipid Profiles in Iranian Men: A Population-Based Screening Program
Abolfazl MOHAMMADBEIGI ; Hamid FARAHANI ; Esmail MOSHIRI ; Mahbobeh SAJADI ; Robabeh AHMADLI ; Sima AFRASHTEH ; Salman KHAZAEI ; Hossein ANSARI
The World Journal of Men's Health 2018;36(1):50-56
PURPOSE: Metabolic syndrome (MS) is characterized by a collection of interdependent disorders, including abdominal obesity, dyslipidemia, hyperglycemia, hypertension, and diabetes. The current study aimed to estimate the prevalence of MS in Qom, Iran. MATERIALS AND METHODS: A population-based screening program was conducted in the city of Qom, in 845 urban adult men over 25 years old in 2014. Abdominal obesity, fasting blood glucose (FBG), blood pressure, and the serum lipid profile were measured in subjects after fasting for at least 8 hours. MS was defined according to the Adult Treatment Panel III criteria. Data were analyzed using the chi-square test, t-test, and multiple logistic regression. RESULTS: The overall prevalence of MS was 23.0%, and the most common prevalent metabolic abnormalities associated with MS were low high-density lipoprotein cholesterol (< 40 mg/dL) in 34.3% of subjects, a waist circumference >102 cm in 33.9%, blood pressure ≥130/85 mmHg in 27.6%, fasting triglycerides (TG) ≥150 mg/dL in 25%, and FBG ≥110 mg/dL in 20.6%. A FBG level ≥110 mg/dL (odds ratio [OR]=4.85; 95% confidence interval [CI], 2.14~8.24), dyslipidemia (OR=3.51; 95% CI, 2.10~5.89), and a fasting TG ≥150 mg/dL were the most important factors contributing to MS. CONCLUSIONS: The prevalence of MS in men in Qom was higher than has been reported in other countries, but it was lower than the mean values that have been reported elsewhere in Iran. FBG was the most important factor contributing to MS, and all elements of the lipid profile showed important associations with MS.
Adult
;
Blood Glucose
;
Blood Pressure
;
Cholesterol
;
Dyslipidemias
;
Fasting
;
Humans
;
Hyperglycemia
;
Hyperlipidemias
;
Hypertension
;
Iran
;
Lipid Metabolism Disorders
;
Lipoproteins
;
Logistic Models
;
Male
;
Mass Screening
;
Obesity, Abdominal
;
Prevalence
;
Triglycerides
;
Waist Circumference
4.Prevalence of HIV, Hepatitis B and C Virus Co-infections among Iranian High-Risk Groups: A Systematic Review and Meta- Analysis
Amir Almasi Hashiani ; Farzin Sadeghi ; Erfan Ayubi ; Shahab Rezaeian ; Yousef Moradi ; Kamyar Mansori ; Behzad Gholamaliei ; Abolfazl Mohammadbeigi ; Salman Khazaei
Malaysian Journal of Medical Sciences 2019;26(3):37-48
Co-infection with hepatitis B and C among HIV infected patients are prevalent among
high-risk populations. This meta-analysis aimed to estimate the prevalence of HIV, HCV and HBV
co-infections among high-risk populations in Iran.
We systematically searched the national and international electronic databases until 2016.
The primary outcome was the prevalence of HIV, HBV, HCV and HIV co-infections in different
high-risk populations in Iran. All English and Persian studies conducted on Iranian high-risk
groups were included in the study. The review was reported based on PRISMA guidelines and data
were analysed at 95% confidence level using random effect models.Overall, 916 relevant papers were recognised and 14 articles were included in the metaanalysis.
The pooled estimates of HBV/HCV, HCV/HIV, HBV/HIV and HBV/HCV/HIV were
1.3% (95%CI: 0.5–2.1), 16.3% (95%CI: 1.1–31.6), 0.5% (95%CI: 0–1.4) and 0.5% (95%CI: 0.2–0.8),
respectively. Based on subgroup analysis, there was a higher proportion of all co-infections from
the years 2010–2016 as compared to that of the years 2003–2009.
Our results highlighted that HCV/HIV co-infection in Iranian high-risk groups including
injection drug users (IDUs) and prisoners is common. In addition, the increasing trend of coinfections
should be considered alarming for policymakers.