1.Ketamine anaesthesia following premedication of rabbits with vitamin C.
Abdullahi ELSA ; Stephen UBANDAWAKI
Journal of Veterinary Science 2005;6(3):239-241
The effects of vitamin C on ketamine anesthesia was studied. In normal rabbits the onset and duration of ketamine induced anesthesia were 6.0+/-0.5 and 36.0+/-0.9 min, respectively. Pre-treatment of rabbits with 30, 60 and 240 mg/kg, i.m. of vitamin C followed by ketamine 40 mg/ kg i.m. resulted in significant (p<0.05)decrease in the onset and increase in duration of ketamine anesthesia to 5.0 +/-0.06 and 37.0+/-0.7;4.0 +/-0.5 and 39.0*0.6;2.0+/-2.3 and 44.0+/-0.8 min, respectively. There was also significant (p<0.05)decrease in the heart rates in the animals treated with vitamin C and ketamine combinations. Serum analysis showed a significant (p<0.05)increase in blood glucose. The observed decreased in serum calcium and phosphorous following ketamine injection was prevented by pretreatment with vitamin C. These results suggest that vitamin C at higher doses could potentiate ketamine anesthesia in rabbits.
Anesthesia/*veterinary
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Anesthesia, General/*veterinary
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*Anesthetics, Dissociative
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Animals
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Ascorbic Acid/*therapeutic use
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Bicarbonates/blood
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Blood Glucose/drug effects
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Body Temperature/drug effects
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Calcium/blood
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Dose-Response Relationship, Drug
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Female
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Heart Rate/drug effects
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*Ketamine
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Male
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Oxygen/blood
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Premedication/*veterinary
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*Rabbits
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Respiration/drug effects