Electronic Medical Records (EMRs) have great value in healthcare, as they enhance healthcare quality, decrease costs, optimize patient safety and health care research. Worldwide and particularly in the Middle Eastern countries have pushed for usage and implement EMR systems. However, there were some obstacles and challenges toward implementation of the EMR system. This review aims to look at the challenges and constraints of using and adopting EMR in Middle Eastern countries. Electronic databases of PubMed, country reports, newspaper, magazine articles, and hospital reports between 2008 to 2021 were used. Most common challenges highlighted were high cost of EMR implementation, lack of training, insufficient information technology personnel support, poor acceptance of new technology, confidentiality, and privacy concerns. Understanding the hurdles of using EMR technology in health care setting is essential for decision makers to focus on economic and human factors challenges to enhance the use and acceptance of EMR systems.