1.Iatrogenic Phaeohyphomycosis: A Rare and Underrecognized Disease
Mong Wayne Lim ; Abdul Rahman Che Abdul Rahim ; Rajalingam Ramalingam
Malaysian Journal of Dermatology 2021;47(Dec 2021):77-80
Summary
Phaeohyphomycosis refers to a heterogenous group of mycotic infections caused by dematiaceous
fungi where unintentional traumatic inoculation accounts for majority of the cases. Herein, we are
reporting a rare case of iatrogenic subcutaneous phaeohyphomycosis which is secondary to intravenous
cannula placement.
Phaeohyphomycosis
;
Iatrogenic Disease
2.Case Series of Akurit-4 Associated DRESS
Abdul Rahman Che Abdul Rahim ; Nurnadwa Zafirah Sabri ; Rajalingam Ramalingam
Malaysian Journal of Dermatology 2021;47(Dec 2021):86-90
Summary
We describe nine cases of anti-tuberculosis DRESS (drug reaction with eosinophilia and systemic
symptoms) syndrome, a potentially serious complication of treatment that led to interruption of
treatment, systemic corticosteroid usage and the resumption of treatment with different regimens. All
patients had skin rash, six out of nine patients with hepatitis, two out of nine patients had acute kidney
injury, five out of nine patients died. All-cause mortality is high in our cohort.
Drug Hypersensitivity Syndrome
3.Serum Vitamin B12 Level and Dietary intake in Adult Atopic Dermatitis: A Case Control Study
Abdul Rahman Che Abdul Rahim ; Mohammad Basri Rusdu ; Adawiyah Jamil ; Rajalingam Ramalingam
Malaysian Journal of Dermatology 2022;49(Dec 2022):12-19
Background:
Vitamin B12 is a contributing factor in pruritus and peripheral nerve regeneration. Its role in atopic
dermatitis (AD) is still unclear. This study aimed to compare vitamin B12 level between AD patients and
healthy controls, determine its correlation with pruritus and AD severity, and evaluate dietary pattern with
energy, macro and micronutrient intakes.
Methods:
This was a case control study involving adult AD patients and age-, gender-, ethnicity- and body mass
index-matched healthy controls. All adult patients who fulfilled UK Working Party AD diagnostic criteria
were included. Exclusion criteria include patients on systemic agents, diseases known to affect B12 level
and vegan diet. AD severity was determined using SCORing Atopic Dermatitis (SCORAD) index. Serum
vitamin B12 level were measured. A three-day 24-hour dietary recall was collected and analyzed.
Results:
A total of 42 AD patients and 42 controls were recruited. Mean SCORAD index was 39.2±16.6, and
AD duration was 12.7 ± 8.1 years. Vitamin B12 was lower among AD (215.6 ± 110.2 pmol/L) versus
control (295.1± 119.9 pmol/L), p<0.01 despite similar dietary B12 intake in both groups. There were no
significant correlations between AD duration and severity with vitamin B12 level. Energy intake (kcal/
day) was significantly lower in AD (p=0.04). There were no significant differences in proportion of main
food groups consumed and other macronutrient and micronutrient intakes.
Conclusion
Serum vitamin B12 level was significantly lower in AD patients despite similar dietary pattern and nutrient
intake with healthy controls. There were no correlations with AD severity or disease duration. Dietary
pattern of AD patients should be routinely assessed to ensure adequate nutrition.
Dermatitis, Atopic--therapy
;
Vitamin B12
;
Diet Therapy
;
Adult