1.Multidrug-resistant Acinetobacter baumannii infection in intensive care unit patients in a hospital with building construction: is there an association?.
Sepideh KAMALBEIK ; Haleh TALAIE ; Arezou MAHDAVINEJAD ; Abdollah KARIMI ; Alireza SALIMI
Korean Journal of Anesthesiology 2014;66(4):295-299
BACKGROUND: Acinetobacter baumannii (A. baumannii) has emerged globally as a significant pathogen in hospitals. It is also present in soil and water. In a previous study, we discovered that the A. baumannii class 2 integron occurred most frequently. Here, we determined whether the A. baumannii class 2 integron is in the soil around our hospital, and if the soil is the cause for increasing numbers of A. baumannii infections in our intensive care unit (ICU) patients. METHODS: This cross-sectional prospective study was conducted in two ICUs at Loghman-Hakim Hospital, Tehran, Iran, from November 2012 to March 2013. Patient, soil, and hospital environment samples were collected. All isolates were identified using standard bacteriologic and biochemical methods. The phenotypes and genotypes were characterized. The standard disc diffusion method was utilized to test antimicrobial susceptibility. Integron identification was performed by multiplex polymerase chain reaction. RESULTS: A total of 42 A. baumannii clinical strains were isolated, all from patient samples; 65% of the isolated species were classified as class 2 integrons. The strains were 100% resistant to piperacillin, piperacillin-tazobactam, ceftazidime, ceftriaxone, cotrimoxazole, cefepime, ceropenem, and cefotaxime. However, all of the strains were sensitive to polymyxin B. A. baumannii was detected around the lip of one patient. CONCLUSIONS: Further research is necessary to establish a relationship between A. baumannii and soil, (especially in regards to its bioremediation), as well as to determine its importance in nosocomial infections and outbreaks in the ICU.
Acinetobacter baumannii*
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Cefotaxime
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Ceftazidime
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Ceftriaxone
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Cross Infection
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Diffusion
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Disease Outbreaks
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Genotype
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Humans
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Integrons
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Intensive Care Units*
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Iran
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Lip
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Multiplex Polymerase Chain Reaction
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Phenotype
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Piperacillin
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Polymyxin B
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Prospective Studies
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Soil
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Trimethoprim, Sulfamethoxazole Drug Combination
2.Evaluation of Lipid Profile Changes in Pediatric Patients with Acute Mononucleosis.
Shirin SAYYAHFAR ; Amin LAVASANI ; Alireza NATEGHIAN ; Abdollah KARIMI
Infection and Chemotherapy 2017;49(1):44-50
BACKGROUND: Acute Epstein-Barr virus (EBV) infection could lead to atherogenic lipid profile changes in adults; while there is no evidence about the children with Infectious mononucleosis (IM). The aim of this study was to evaluate the lipid profile of the children in acute phase of mononucleosis and two months after the recovery. MATERIALS AND METHODS: From 2010 through 2012, 36 children with IM aged 1-10 years were enrolled in a prospective cross-sectional study. Fasting serum total cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), and triglyceride level were measured during acute phase of the disease and after 2 months of the recovery. RESULTS: From 36 patients enrolled, 25 (69.4%) cases were male and the mean age of the patients was 4.1 ± 2.0 years. The mean of the total cholesterol level in the acute phase and 2 months after the recovery were149.5 ± 35.3 mg/dL and 145.7±30.6, respectively (P = 0.38). However, the serum level of HDL cholesterol in patients after 2 months of recovery was significantly increased (37.9 ± 9.3 mg/dL vs. 28.5 ± 10.6 mg/dL, P <0.001). The mean value of serum LDL cholesterol was significantly reduced, two months after recovery (81.4 ± 19.5 mg/dL, vs. 92.6 ± 28.8 mg/dL, P = 0.009). Furthermore, the serum triglyceride level was significantly reduced after the recovery (108.7 ± 36.9 mg/dL) compared with the acute phase (163.8 ± 114.3 mg/dL) (P = 0.004). CONCLUSION: EBV infection in children could change lipid profile which is partially restored 2 months after the recovery.
Adult
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Child
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Cholesterol
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Cholesterol, HDL
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Cholesterol, LDL
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Cross-Sectional Studies
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Epstein-Barr Virus Infections
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Fasting
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Herpesvirus 4, Human
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Humans
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Infectious Mononucleosis
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Lipoproteins
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Male
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Pediatrics
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Prospective Studies
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Triglycerides