The modest pressure promotes the graduate to keep continuous energy and focus on scientific research,but too much pressure will lead to mental problem and serious moral shortcoming.Reformation of scientific evaluating and promoting system,enhancement of scientific interest and reconstruction of mental training system should be the important ways to release the pressure of scientific research of the graduate.

HbA1C has been used clinically since 1980s as the index of glycemic control in individuals with diabetes mellitus.Several significant clinical trials demonstrated that the intensive blood glucose control reduced the chronic complications in diabetes.In recent years,HbA1C has been recommended as one of the diagnostic criteria for diabetes mellitus.However,the standardization of HbA1C measurement still remains to be an important and arduous task in China.

Objective To investigate the early diagnosis and preventive measures for gestational hypertensive patients with heart disease.Methods Clinical data of 56 gestational hypertensive patients with heart disease were retrospectively analyzed.Results Aggressive treatment of maternal deaths occured in 1 case,2 cases of stillbirth,and the other 55 cases had good maternal prognosis.Conclusion Treatment of hypertensive heart disease in pregnancy should be based on the strong heart vasodilator,diuretic,caution magnesium sulfate.In the control of heart failure after 6-8h,shall terminate the pregnancy.Active treatment of the primary disease,to correct anemia and hypoproteinemia,early diagnosis of heart failure and strictly control expansion of indications can help to improve the prognosis of hypertensive heart disease in pregnancy.

Lung cancer-related papers published by authors of China were retrieved from PubMed and the high frequency subject headings and subheadings were extracted from them using the Bicomb system.The status quo and hot spots of lung cancer-related studies in China were analyzed .

Objective To investigate the damage of mice liver and kidney with the compatibility application of Paeoniae radix rubra and Veratrum nigrum, and explore its mechanism. Methods We examined the alanine aminotransferase, aspartate aminotransferase (AST), lactic dehydrogenase, creatinine and urea nitrogen from serum, and glutathion peroxidase (GSH-Px) and malondialdehyde (MDA) from liver and kidney tissue after intragastric administration of different ratio (4∶1, 2∶1, 1∶1, 1∶2, 1∶4) of Paeoniae radix rubra and Veratrum nigrum in mice for 22 d. Results Paeoniae radix rubra used with Veratrum nigrum did not induce the obvious damage to liver with AST increase, but induced the obvious damage to kidney. At the same time, the depressed GSH-Px activity and the increased MDA content were observed in kidney tissue. When Paeoniae radix rubra and Veratrum nigrum is on a ratio of 2∶1, the kidney injury was the most obvious. Conclusion Paeoniae radix rubra used with Veratrum nigrum in varying proportions could induce the kidney injury in mice which is related to the oxidation-antioxidation balance disturbance.

Objective To study the effect of improved laparoscopic techniques on ability of control urine in patients with prostate cancer.Methods 96 patients with prostate cancer were randomly divided into two groups,the observation group(51 cases) and the control group(45 cases).The patients in the control group were operated through the conventional treatment,while the patients in the observation group were operated through the improved laparoscopic technique,which protected the external urethral sphincter,reserved urinary nerve and reconstructed the bladder neck.The ability to control urine for 30,60 and 90 days were compared between two groups.Results The time of operation and bleeding of operation had no significant differences between two groups (all P ＞ 0.05).There were significant differences between two groups in indwelling catheter time and the ability to control urine for 30 ;60 and 90 days (t=10.0359,P＜0.05;t=7.9746,14.0205,10.8445,all P＜0.01).Conclusion Improved laparoscopic technique can improve the ability of control urine in patients with prostate cancer after operation.

ObjectiveTo evaluate the efficacy and safety of ibutilide for conversion of paroxysmal and persistent atrial fibrillation.Methods31 patients with atrial fibrillation duration less than 90 days were included into amiodrone or ibutilide group.16 patients were intravenously administer with amiodrone and 15 patients with ibutilide separately.Conversion rate,time needed to converse and adverse effects were compared between two groups.ResultsThe total conversion rate of ibutilide group was significantly higher than that of amiodrone group (66.7％ vs 37.5％,x2 =1.98,P ＜ 0.05 ).Time needed to converse was significantly shortened in ibutilide group compared with amiodrone group [ ( 31.75 ± 7.39 ) min vs ( 51.87 ± 9.26 ) min,t =3.67,P ＜ 0.05 ].No clinical significant adverse effects were observed in ibutilide group.ConclusionIntravenous administration of ibutilide in cardioversion of paroxysmal and persistent atrial fibrillation was more safe and effective than amiodrone.

Allogeneic hematopoietie stem cell transplantation(alloHSCT) is a potentially curative therapy for patients with hematological malignant disease, autoimmune disease or hereditary disease.However, graftversus-host disease (GVHD), which is one of the most serious complications, influences the prognosis of alloHSCT. Mechanisms of GVHD is so complicated that there is still no perfect way to treat the patients at present. Recently, mesenchymal stem cells(MSC) become new hotspots because of their immunomodulatory properties and potential to suppress alloreactive T cell responses.Animal experiments showed that MSC were effective during the prevention and treatment of GVHD. This paper is to summarize the acting mechanism of MSC' effect on the prevention and treatment of GVHD after alloHSCT.

Liraglutide is a long-acting human GLP-1 analogue,which provides pharmacological level of GLP-1 and combines with GLP-1 receptor widely distributing in the body.Liraglutide demonstrates multiple antidiabetic and other effects,including glucose-dependent glucose-lowering action,pancreatic islet cells protection,gastric emptying inhibition,appetite reduction/feelings of satiety and fullness increasing,weight loss,cardioprotection and blood pressure lowering action.Meanwhile,clinical practice also shows that some gastrointestinal adverse events occur accompanying with good glucose control and weight loss.This review will explain the potential mechanisms of GLP-1 and gastrointestinal reaction,clinical evidence of liraglutide and effective management rules,aim to help readers better understand this issue,as well as to advise clinicians of proper use of liraglutide while reducing or avoiding those adverse events.

Objective To explore the influencing factors of hypertensive cerebral hemorrhage in 68 patients with supratentorial prognosis of recovery of neurological function.Methods Clinical data of 68 patients with high blood pressure treatment supratentorial intracerebral hemorrhage,and brain CT,laboratory data were retrospectively analyzed.Neurological functions and related indicators change of were daalyzed by univariate and multivariate Logistic regression analysis.Results Gender,systolic blood pressure,diastolic blood pressure,red blood cell count,such as the impact on the prognosis was not statistically significant(all P ＞ 0.05) ; median line offset,nosocomial infections,surgery,gastrointestinal bleeding,heart failure,treatment Barthel index(BI) were a significant influence on the prognosis (all P ＜ 0.01).The median line offset,nosocomial infections,bleeding,gastrointestinal bleeding,heart failure,BI integration were the main factors affecting the prognosis of neurological function recovery.Conclusion The factors which affects nerve function recovery is an important part of improving neurological outcomes.We should emphasize them.