The modest pressure promotes the graduate to keep continuous energy and focus on scientific research,but too much pressure will lead to mental problem and serious moral shortcoming.Reformation of scientific evaluating and promoting system,enhancement of scientific interest and reconstruction of mental training system should be the important ways to release the pressure of scientific research of the graduate.

Objective To introduce human telomerase reverse transcriptase(hTERT) gene and evaluate the significance in regulating telomerase activity(TA). Methods The related literatures in recent 4 years were reviewed. Results hTERT belongs to the transcriptase family. Its expression is strictly regulated at both transcriptional and posttranscriptional levels. hTERT plays a key role in the regulation of TA. There are at least two regulatory mechanisms controlling the activity of telomerase. One is transcriptional control of the hTERT, and the other is selective(alternate) splicing of hTERT transcripts. Conclusions Among the factors regulating the TA, hTERT has showed to be a crucial factor.

Objective To analyze the current situation in studies of translational medicine in Guangdong Province. Methods The number of centers for translational medicine,academic conferences,scientific fund-supported projects, and academic papers was calculated,respectively. Results Guangdong Province established 24 centers for transla-tional medicine,held 22 academic conferences,completed 42 scientific projects,and published 79 academic papers in domestic and foreign journals, including 12 papers concerned about traditional Chinese Medcine. Conclusion Guangdong Province have made some achievements in translational medicine that present certain development rules. It is suggested that in the future,the government should pay more attention to the development of translational medi-cine research. In order to promote the development of translational medicine research in Guangdong province, the government should try to combine the development of translational medicine research and the development of provin-cial key laboratory and key disciplines in Guangdong province.

Taking the Fourth Affiliated Hospital of China Medical University as an example,the information integration platform of the hospital is constructed in accordance with the national data and information interaction standard and HL7 standard.The paper introduces the idea for selecting platform products,and technical route and effect of platform construction,and provides guarantee for sustainable development of the hospital,in order to greatly improve core competitiveness of the hospital.

Objective:As a new strategic industry,health industry was related to the national economy and the livelihood of residents.To probe into the current situation and problems of health industry in Liaoning so as to provide reference for the sustainable development of health industry in Liaoning.Methods:Using the method of literature analysis and interview to explore the comparative advantages and the bottleneck factors of the development of health industry in Liaoning.Results:Liaoning Province medicinal resources were rich and unique,with strong industrial base and protruding industrial cluster advantage,which had leading enterprises significant demonstration effect.Meanwhile,the healthy development of the industry was the imbalanced in regional development,lack of industry standards,lack of R & D innovation,health industry talent scarcity etc.Conclusion:Combined with the actual situation and problems of the development of health industry in Liaoning,it put forward countermeasures and suggestions to provide strategic thinking for improving the development of the health industry in Liaoning.

AIM: To establish a new method for quick identifying Shuanghuanglian Oral Liquid(Flos Lonicerae japonicae,Radix Scutella riae,Fructus Forsythiae) by AOTF-Near infrared spectroscopy. METHODS: Near infrared spectroscopy combined with principal component analysis. RESULTS: The model SHL-C of Shuanghuanglian Oral Liquid could distinguish Shuanghuanglian Oral Liquid from Yinhuang Oral Liquid and other 9 kinds of these(oral) liquids. CONCLUSION: The method is quick,simple and low cost assay technique and can be used to identification of Shnanghuanglian Oral Liquid.

Objective:To investigate the effects on the activity of acetylcholinesterase (AchE) and choline acetylase(ChAT) in filial rat’s brian and learning and memory capacity after the mother-rat is exposed to nonylphenol. Methods:At the first day of the pregnancy,the rats were divided into four groups,which were orally administered with NP at doses of 0,50,100 and 200 mg/kg,respectively,on gestational days 9～15. The offspring rats’s Brain tissues of each groups were dissected for AchE and ChAT activity assay and cognitive function was tested by Morris water maze. Result:Morris water maze test results showed the escape latency was longer in the groups of NP 200 mg/kg than in control group(P

Objective:Toinvestigate the expression of RHAMMgene and TPX2 gene in esophageal squamous cell carcinoma(ESCC)and their relationships with clinicopathological factors.Methods:The expression of RHAMM gene and TPX2 gene were detected by reverse transcriptase polymerase chain reaction(RT-PCR)in ESCC tissues,para-cancer tissues,and matched esophageal normal mucosa tissues of 40 patients.Results:The positive expressions of RHAMM mRNA in ESCC tissues(65.0%)were significantly higher than those in para-cancer tissues(37.5%)and esophageal normal mucosa tissues(22.5%).Significant relationship was observed between positive expression of RHAMM mRNA and lymphnode metastasis(P

OBJECTIVE To discuss the relevant factors and preventive measures of nosocomial infection Cancer patients undergoing chemotherapy. METHODS The clinical data of 957 malignant tumor patient′s were retrospectively analyzed. RESULTS 62 patient′s occurred nosocomial infection after Chemotherapy and the rate of infection was 6.48%. The infection site in the respiratory tract accounted for 45.16%; the most commons lung cancer accounted for 33.87%. The patient′s age, length of stay, decreased total number of white blood; long-term use of broad-spectrum antibiotics was the risk factor of nosocomial infection. CONCLUSIONS The imunity of the patients reduced after chemotherapy and nosocomial infection rate increas. We must take some effective prevention measures for the risk factors to reduce nosocomial infection.

Objective To illustrate the application of fluoronavigation in Gamma nailing—a common surgical procedure in treatment of intertrochanteric fracture of femur and to compare the newly designed Gamma-3 system for navigation with the Gamma-AP system. Methods 66 patients with intertrochanteric fractures underwent Gamma nailing (40 Gamma-AP and 26 Gamma-3) under fluoronavigation guidance. An observer recorded the different intra-operative parameters. Results The Gamma-3 group showed superior results of shorter operation time (averaging 32 minutes), smaller surgical wound size (5cm), less X-ray requirement during procedure (7 times) and at the same time better lag screw position (Tip-Apex-Distance 17.9 mm). Conclusions Fluoronavigation can facilitate gamma nailing as a minimally invasive surgery because of its accurate guidance to nail insertion and lag screw positioning, a smaller surgical wound and minimized X-ray exposure suffered by operation theater staff. The Gamma-3 system has shown better results than the Gamma-AP system because of its navigation-specific design.