[Purpose] A leg press generally included in a weight training program to develop the quadriceps. However little is known about the mechanism of the load in lower extremity by the different knee alignment. The purpose of this study is to compare the muscle activity in the different knee align ment during leg press exercise. [Methods] Four normal knee and Five gene varum performed the leg press using three stance of narrow, medium and wide stance with the load of 75%/1 RM. Surface EMG date were collected (1000Hz) from vastus medialis (VM), vastus lateralis (VL), rectus femoris (RF), adductor longus (AL), biceps lemons (HF), tibialis anterior (TA), gastrocnemius (GAS), soleus (SQL) . Integrated EMG (iEMG) values were calculated for each muscle during each rep. A video camera recorded the performing form during leg press from the frontal plane. [Results and Discussion] As the leg press was to strengthen of the thigh muscle, VM, VL and RF of both groups worked strongly. However SQL of genu varum worked as strong as the level of activity of the thigh, iEMG of the SQL showed low value significantly by using wide stance. When the genu varum group performed maximal knee flexion using the narrow, their ankle was valuus on the video screen. This result may become cause of SQL higher activity during leg press. From this we can derive the argument that it will be necessary to take that stance into consideration when athletes who are genu varum performs leg press.