1.Targeted yield concept and a framework of fertilizer recommendation in irrigated rice domains of subtropical India
R. BERA ; A. SEAL ; P. BHATTACHARYYA ; T.H. DAS ; D. SARKAR ; K. KANGJOO
Journal of Zhejiang University. Science. B 2006;7(12):963-968
Soil test crop response (STCR) correlation studies were carried out in Vindhyan alluvial plain during 2001 to 2004taking IR-36 as test crop to quantify rice production in the context of the variability of soil properties and use of balanced fertilizers based on targeted yield concept. The soils were developed on gently sloping alluvial plain with different physiographic settings and notable variation in drainage condition. Soil properties show moderate variation in texture (loamy to clay), organic carbon content (4.4 to 9.8 g/kg), cation exchange capacity (10.2 to 22.4 cmol (p+)/kg) and pH (5.3 to 6.4). Soil fertility status for N is low to medium (224 to 348 kg/ha), P is medium to high (87 to 320 kg/ha) and K ranges from medium to high (158 to 678 kg/ha).Database regarding nutrient requirement in kg/t of grain produce (NR), the percent contribution from the soil available nutrients [CS (%)] and the percent contribution from the applied fertilizer nutrients [CF (%)] were computed for calibrating and formulating fertilizer recommendations. Validity of the yield target for 7 and 8 t/ha was tested in farmers' fields and yields targets varied at less than 10%. The percent achievement of targets aimed at different level was more than 90%, indicating soil test based fertilizer recommendation approach was economically viable within the agro-ecological zone with relatively uniform cropping practices and socio-economic conditions.
2.Therapeutic Potential of Human Adipose Stem Cells in a Rat Myocardial Infarction Model.
Seal HWANGBO ; Jongok KIM ; Sungho HER ; Hyekyung CHO ; Jongho LEE
Yonsei Medical Journal 2010;51(1):69-76
PURPOSE: Stem cell transplantation is expected to have good effects in the treatment of myocardial infarction (MI). We tested the effect of the transplantation of human adipose-derived cells (ASCs) in Sprague-Dawley (SD) rats with myocardial infarctions. MATERIALS AND METHODS: ASCs were isolated from the waste of elective abdominal surgery. The MI model was set up in SD rats by permanent ligation of the left anterior descending coronary artery. One week after MI, either 1 x 10(6) ASCs or an equal volume of phosphate-buffered saline (PBS) was injected into the infarct zone. Cardiac function was assessed by echocardiography, 1 day, 1 week, 2 weeks, and 4 weeks after treatment. Four weeks after transplantation, immunohistochemistry was performed. RESULTS: Left ventricular function, including fractional shortening (FS), and ejection fraction (EF) showed a significant improvement in the ASCs transplantation group compared to the PBS group 4 weeks after treatment (p < 0.05). The anterior wall thickness of the left ventricle was significantly thicker in the ASCs transplantation group compared to the PBS group (p < 0.01). Multiple troponin T staining, and irregular, small amounts of connexin 43 expression also was observed in the ASCs transplantation group. Infarcted myocardium showed higher capillary density in the ASCs transplantation group than in the PBS injected group (p < 0.01). CONCLUSION: This study provides encouraging evidence that transplantation of ASCs can improve cardiac function of infarct myocardium in rat models with a limitation of cardiac remodeling, improved wall thickness, and increased neovascularization.
Adipose Tissue/*cytology
;
Animals
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Cells, Cultured
;
Disease Models, Animal
;
Echocardiography
;
Humans
;
Immunohistochemistry
;
Male
;
Mesenchymal Stem Cell Transplantation/*methods
;
Myocardial Infarction/metabolism/*therapy
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Rats
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Rats, Sprague-Dawley
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Ventricular Function, Left
3.Two Separated Ileal Adenocarcinomas in Neurofibromatosis Type 1.
Seal HWANGBO ; Jiyoun KIM ; Hyun KIM ; Jongok KIM ; Changsuk KANG ; Hyekyung LEE
Yonsei Medical Journal 2007;48(6):1039-1042
Patients with neurofibromatosis-1 (NF-1) have increased susceptibility to a variety of malignancies. Here, we document a rare case of two separated ileal adenocarcinomas in NF-1. The adenocarcinomas were surrounded by a diffuse tubular adenomatous lesion of the mucosa, and ganglion cells were scattered in the NF background. We found this case meaningful for several reasons: two separated adenocarcinomas arising in an unusual ileal segment, the association with precancerous tubular adenoma, and the presence of ganglion cells, which suggests ganglioneuromatosis in NF-1.
Adenocarcinoma/complications/*pathology
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Adult
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Humans
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Ileal Neoplasms/complications/*pathology
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Ileum/pathology
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Intestinal Mucosa/pathology
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Male
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Neurofibromatosis 1/complications/*pathology
4.A Case of a Tailgut Cyst.
Sin Sun KIM ; Ji Yeon KIM ; Hye Kyung LEE ; Seal HWANGBO ; Jeong Gu KIM ; Dong Ho LEE ; Young Kyoung YOU ; Chang Joon AHN
Journal of the Korean Society of Coloproctology 2005;21(2):105-108
The tailgut is a blind extension of the hindgut into the tail fold just distal to the cloacal membrane. Remnants of this structure may form a tailgut cyst. This is prone to infection and chronic fistula formation and has a long-term risk of malignancy. Non-recognition and incomplete treatment leads to morbidity. A twenty one year-old female patient visited our hospital with repeated perianal pain and discharge. Preoperative abdominopelvic MRI and endorectal ultrasonography revealed a retrorectal cyst suggestive of a tailgut cyst. She underwent a complete excision of the retrorectal mass through a presacral approach. She recovered uneventfully. This report includes the case and a brief review of tailgut cysts.
Female
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Fistula
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Humans
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Magnetic Resonance Imaging
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Membranes
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Ultrasonography
5.Imaging Findings of Midgut Volvulus Associated with a Large Small-Bowel Diverticulum in an Adult Patient: Case Report.
Jee Young KIM ; Sung Eun RHA ; Soon Nam OH ; Seal HWANG-BO ; Jae Young BYUN
Journal of the Korean Radiological Society 2004;50(5):365-368
Although most patients with jejunoileal diverticulum are asymptomatic, a large, small-bowel diverticulum can be associated with midgut volvulus in an adult. We present a rare case of midgut volvulus that was associated with a large, small-bowel diverticulum in a 77-year-old woman presenting with chronic recurrent abdominal pain. The CT showed the characteristic whirl sign of twisted mesentery, the small bowel loops along the superior mesenteric artery and a large sac-like small-bowel diverticulum. A small bowel series also demonstrated a corkscrew appearance of proximal jejunum, a finding suggestive of midgut volvulus, and a large jejunal diverticulum. During the laparotomy, the small bowel was seen twisted counterclockwise 270 degree. The mesenteric root was very shortened. A 4 cm sized diverticulum was seen on the mesenteric border of jejunum, on the portion about 40 cm distal from the Treitz ligament.
Abdominal Pain
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Adult*
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Aged
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Diverticulum*
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Female
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Humans
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Intestinal Volvulus*
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Jejunum
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Laparotomy
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Ligaments
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Mesenteric Artery, Superior
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Mesentery
6.Pulmonary Actinomycosis: CT Studies of Diagnostic and Post-treatment Findings.
Su Jung KIM ; Sun Wha SONG ; Seal HWANG-BO ; Hyun Jin PARK ; Hyeon Sook KIM ; Ki Jun KIM ; Horrim KIM ; Seog Hee PARK
Journal of the Korean Radiological Society 2008;58(5):487-494
PURPOSE: To investigate the value of the computed tomography (CT) in the study of diagnostic and post-treatment findings of pulmonary actinomycosis. MATERIALS AND METHODS: Clinical data and CT findings were retrospectively analyzed in 10 patients with histopathologically confirmed pulmonary actinomycosis. We analyzed the initial CT findings in search of patterns and distributions which suggest possible lung abnormalities and found the pleura, chest wall, and lymphadenopathy to be involved as part of the indicators of lung abnormalities. We analyzed follow-up CT findings for changes in the lungs after antibiotic therapy and recurrence after surgery. RESULTS: Of the 10 patients analyzed by CT for lung lesions, seven had been diagnosed with alcoholism and nine were male. The initial CTs (n=10) indicated that all the pulmonary lesions were solitary without chest wall involvement. However, a transfissural extension was observed in 20% of the study population (n=2). Furthermore, peripheral lung distribution and adjacent pleural thickening was observed in 70% of the study population (n=7). Within the consolidation (n=6) or mass (n=4), a central low density with peripheral enhancement was seen in 70% of the study population (n=7). A follow-up CT of the seven cases following antiobiotic therapy revealed that four cases showed minimal improvement or aggravation of their lung lesions, whereas three cases showed resolution or improvement. The improvement of the central low density was related to the improvement of consolidation or mass. Furthermore the presence of fibrosis was observed after the resolution of pulmonary lesions (n=2). No relationship was found between the duration and response of antibiotic therapy. A follow-up CT (n=4) subsequent to a lung resection revealed the onset of chest wall actinomycosis and a thickened pleura in one case. CONCLUSION: The results of this study highlight the value of the CT in pulmonary actinomycosis in order to diagnose and evaluate antibiotic responses, complications, or post-surgical recurrences of lung lesions.
Actinomycosis
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Alcoholism
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Fibrosis
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Follow-Up Studies
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Humans
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Lung
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Lung Diseases
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Lymphatic Diseases
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Male
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Pleura
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Recurrence
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Retrospective Studies
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Thoracic Diseases
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Thoracic Wall
;
Tomography, X-Ray Computed
7.Brain Diffusion Tensor MR Imaging.
Hyun Jeong KIM ; Choong Gon CHOI ; Jeong Hyun LEE ; Po Song YANG ; Siwon KANG ; Yeon Soo LEE ; Ji Chang KIM ; Bo Seal HWANG
Journal of the Korean Radiological Society 2005;53(4):233-243
The development of MR imaging techniques during the past decade has enabled researchers to use MR imaging as a noninvasive tool for evaluating structural and physiologic states in biologic tissues by measuring the diffusion process of water molecules. More recently, diffusion tensor MR imaging (DTI) technique based on the dependency of molecular diffusion on the orientation of white matter fiber tracts has been used to analyze the trajectory, shape, fiber structure, location, topology and connectivity of neuronal fiber pathways in living humans. Numerous efforts have been made by MR physicists, brain scientists, and medical doctors to advance MR techniques and computer-based algorithms which result in more accurate quantification of diffusion tensor and the generation of white matter fiber tract maps and to determine the pathophysiology of brain disease by DTI and useful clinical applications of DTI. In this article, we describe the tensor theory used to characterize molecular diffusion in white matter and a process of measuring tensor elements using diffusion-sensitive MR images to fiber mapping. We then provide review of current literature and some clinical examples that have been published and are on-going.
Brain Diseases
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Brain*
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Diffusion*
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Humans
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Magnetic Resonance Imaging*
;
Neurons
8.Effect of Silicon Dioxide and Magnesium Oxide on the Printability, Degradability, Mechanical Strength and Bioactivity of 3D Printed Poly (Lactic Acid)-Tricalcium Phosphate Composite Scaffolds
Samarah V. HARB ; Elayaraja KOLANTHAI ; Eduardo H. BACKES ; Cesar A. G. BEATRICE ; Leonardo A. PINTO ; Ana Carolina C. NUNES ; Heloisa S. SELISTRE-DE-ARAÚJO ; Lidiane C. COSTA ; Sudipta SEAL ; Luiz Antonio PESSAN
Tissue Engineering and Regenerative Medicine 2024;21(2):223-242
BACKGROUND:
Poly (lactic acid) (PLA) is a biodegradable polyester that has been exploited for a variety of biomedical applications, including tissue engineering. The incorporation of b-tricalcium phosphate (TCP) into PLA has imparted bioactivity to the polymeric matrix.
METHODS:
We have modified a 90%PLA-10%TCP composite with SiO2 and MgO (1, 5 and 10 wt%), separately, to further enhance the material bioactivity. Filaments were prepared by extrusion, and scaffolds were fabricated using 3D printing technology associated with fused filament fabrication.
RESULTS:
The PLA-TCP-SiO2 composites presented similar structural, thermal, and rheological properties to control PLA and PLA-TCP. In contrast, the PLA-TCP-MgO composites displayed absence of crystallinity, lower polymericmolecular weight, accelerated degradation ratio, and decreased viscosity within the 3D printing shear rate range. SiO2 andMgO particles were homogeneously dispersed within the PLA and their incorporation increased the roughness and protein adsorption of the scaffold, compared to a PLA-TCP scaffold. This favorable surface modification promoted cell prolif-eration, suggesting that SiO2 and MgO may have potential for enhancing the bio-integration of scaffolds in tissueengineering applications. However, high loads of MgO accelerated the polymeric degradation, leading to an acid environment that imparted the composite biocompatibility. The presence of SiO2 stimulated mesenchymal stem cells differentiation towards osteoblast; enhancing extracellular matrix mineralization, alkaline phosphatase (ALP) activity, and bonerelated genes expression.
CONCLUSION
The PLA-10%TCP-10%SiO2 composite presented the most promising results, especially for bone tissue regeneration, due to its intense osteogenic behavior. PLA-10%TCP-10%SiO2 could be used as an alternative implant forbone tissue engineering application.