OBJECTIVE:To facilitate the construction of Chinese pharmaceutical profession associations. METHODS: We analyzed the current situation and problems existing in Chinese pharmaceutical profession association as well as the developmental experience of foreign pharmaceutical associations then put forward suggestions for the development of pharmaceutical profession associations in China. RESULTS & CONCLUSIONS: The sound development of pharmaceutical profession associations calls for the cooperated efforts of government, profession association and pharmaceutical enterprises, meanwhile its function as bridge and tie between pharmaceutical enterprises and government should be brought into full play.

Chronic Disease ; Cone-Beam Computed Tomography ; Humans ; Periapical Abscess ; pathology ; Periapical Granuloma ; pathology ; Periapical Periodontitis ; diagnostic imaging ; pathology ; Problem Solving ; Prognosis ; Radicular Cyst ; diagnostic imaging ; pathology

Objective To explore the correlation between the MSCT sign of gastric cancer and the expression of human epidermal growth factor receptor 2 (HER2)gene in the cancer tissues.Methods 105 cases of gastric cancer diagnosed by pathology after sur-gery underwent MSCT before surgery,then the correlation was analyzed between MSCT shows and the expression of HER2 gene detected by immunohistochemistry after surgery by the statistical method.Results The age,sex,site of tumor,stage and CT value of plain scan were not correlated with the expression of HER2 (P>0.05).Compared to the group without HER2 expression,CT value in venous phase,the enhancement degree in both arterial and venous phase and the incidence of enlarged lymph nodes around the stomach were higher in HER2 positive expression group,the differences were significant (P<0.05),while CT value in arterial phase were not significantly different (P>0.05).Compared to the HER2 (0&1+)group,CT value,the enhancement agree in venous phase and the incidence of enlarged lymph nodes around the stomach were higher,in HER2 (2+&3+)group,the differences were significant (P<0.05),while CT value and the enhancement in arterial phase were not significantly different (P>0.05).Conclusion There are different signs in MSCT with different expression of HER2 in gastric cancer,the combinations of them can evaluate the prognosis of gastric cancer.

Objective To discuss the safety and feasibility of radiofrequency ablation (RFA)combined with transcatheter arterial chemoembolization(TACE)for patients with primary liver carcer(PLC).Methods 64 cases with PLC were selected and randomly divided into two groups,32 cases in each group.The observation group accepted TACE combined with RFA therapy,while the control group only received TACE treatment.Term efficacy (after 1 year)and 1,2,3 -year survival rate were compared in the two groups.The changes of liver function parameters including aspartate aminotransferase (AST),alanine aminotransferase (ALT) and γ-aminoacyl transferase (γ-GT)of the two groups were analyzed and compared.Results After 1 year of treatment,the remission rate was 71.9% (23 /32)in the observation group,which in the control group was 43.8% (14 /32),the difference was statis-tically significant (χ2 =5.189,P <0.05).The 1,2,3 -year cumulative survival rates were 65.6% (21 /32),65.6%(21 /32)and 62.5% (20 /32)in the observation group,which in the control group were 37.5% (12 /32),28.1%(9 /32)and 21.9% (7 /32),the differences were statistically significant (χ2 =5.067,9.035,10.83,all P <0.05). After 2 months of treatment,AST,ALT and γ-GT levels in the observation group were significantly higher than those in the control group(t =4.218,2.449,8.647,all P <0.05).Conclusion TACE combined with RFA therapy can significantly improve the clinical symptoms of patients with PLC,which can improve liver function in patients and help prolong the survival time.

Objective To discuss the relationship of miR-21 expression and IL-12 level in patients with chronic obstructive pulmonary disease.Methods Chosed 80 patients with suspected chronic obstructive pulmonary disease(COPD)and 50 cases as control group.Real-time RT-PCR was performed to determine the expression 1 evels of miR-2 1 of peripheral blood mono-nuclear cells of three groups.To detect IL-1 2 level by ELISA method.Results There were no statistical difference among GLU,TC and TG level among stable phage,acute phage of COPD and control group(F=0.341~1.542,P>0.05).Howev-er miR-21 expression and IL-12 level had statistical difference (F=8.951~15.017,P<0.05).The expression 1evels of miR-2 1 of peripheral blood mononuclear cells of acute phage group were apparently higher than stable phage,health group(P<0.05).The concentration of IL-12 in serum of acute COPD group was higher than other two groups(P<0.05),compared with stable COPD group and health group.IL-12 level was positiveiy related to miR-21 expression (r=-0.381~0.496). Conclusion miR-2lmay be involved in the regulation of IL-12 expression.miR-21expression may be closely related to the pathogenesis of COPD.

Objective To investigate the application effect of the puncture method of indwelling needle by single hand in clinical attendance of pediatrics. Methods From March 2015 to September 2015,578 patients in our pediatrics were randomly and equally divided into two groups. The experiment group were treated with the puncture method of indwelling needle by single hand and the control group received traditional puncturing method. Results There were statistical significances in the success rate of first puncture,degree of comfort,sense of pain,dropping of the indwelling needle,phlebitis,exosmosis of drugs and indwelling time of patients between the two groups(P< 0.05). Conclusion In the process of using indwelling needle in pediatrics,the application of the puncture method of indwelling needle by single hand could improve the success rate of first puncture of venous retention needle,enhance the comfort degree of neonates,relieve the sense of pain,reduce the dropping of the indwelling needle,incidence of phlebitis and exosmosis of drugs,and prolong the indwelling time. The operation of this puncture is simple and easy to do and to learn,without any special equipment. In the venous puncture,the only necessities are 24G retention needle,3M indwelling needle and adhesive tape. Obviously,it is economical and practical,and is suitable for application in clinic.

Objective To investigate the clinical efficacy of auricular plaster therapy plus scalp acupuncture in treating post-stroke depression.Methods One hundred and twenty-five patients with post-stroke depression were randomly allocated to group A of 42 cases, group B of 42 cases and group C of 41 cases. Group A received scalp acupuncture alone; group B, auricular plaster therapy alone; group C, auricular plaster therapy plus scalp acupuncture. The Hamilton Depression Scale (HAMD) score was recorded in the three groups before and after treatment. The clinical therapeutic effects were compared between the three groups. Results There was a statistically significant pre-/post-treatment difference in the HAMD score in the three groups after two months of treatment (P<0.01). There was a statistically significant difference in the HAMD score between group C and group A or B after one and two months of treatment (P<0.05). The total effective rate and marked efficacy rate were respectively 95.0% and 33.3% in group A, versus 88.1% and 35.7% in group B, and 92.7% and 56.1% in group C, and the marked efficacy rate in group C were significantly different from that in group A and group B (P<0.05). There is not a statistically significant difference in the total effective rate among the three groups (P>0.05).Conclusion Auricular plaster therapy plus scalp acupuncture is an effective way to treat post-stroke depression.

The myocardial calcium paradox model was made on isolated perfused guinea-pig heart. Sodium tanshinonc Ⅱ_A sulfonate (DS-201) was used as a protection agent. The protein release and the calcium uptake of the myocardium were measured to observe and evaluate the protection effect of DS-201 against myocardial calcium paradox. The effect was compared with that of verapamil, a known calcium antagonist, to study the calcium antagonism of DS-201. The results demonstrated that DS-201 acted as a calcium antagonist and contributed an outstanding protection to myocarcial calcium para- dox. DS-201 inhibited the calcium uptake and the protien (enzymes) release of the myocardium occured during the calcium paradox (P

Objective To investigate the application effect of indwelling needle puncture in the axillary vein of newborn infants.Methods From September 2015 to February 2016,the venous indwelling needle puncture was given for neonatal transfusion 180 cases,including 90 cases of the axillary vein indwelling needle infusion in the experimental group,and 90 cases of puncture of extremity vein infusion in the control group.The application effect of the 2 groups was compared.Results There were significant differences in terms of indwelling needle shedding,phlebitis,drug extravasation,lien time between the experimental group and the control group (P ＜ 0.05) Conclusions During neonatal indwelling needle puncture infusion process,the axillary vein indwelling needle infusion can prevent the indwelling needle shedding,decrease the incidence of phlebitis and reduce the incidence of drug extravasation,and can prolong the indwelling time.Puncture in the simple operation easy,is easy to learn and no need for special facilities and equipment,only conventional intravenous infusion required material,plus 24g indwelling needle,aseptic transparent dressing,paper tape,economical and practical,suitable for application in neonatal ward.

The author got an opportunity to know about the Thai traditional medicine, especially its application and efficacy in treatment of Bi syndrome via the communication with Thai healers in the duration of teaching and working in Chandrakasem Rajabhat University due to an invitation.This paper will simply discuss the similarities and differences between the treatments with traditional Thai medicine and traditional Chinese medicine for Bi syndrome in terms of their theory systems, the understanding of Bi syndrome, as well as the characteristics of therapies.And I hope this paper will provide certain help in the academic exchanges between these two traditional medicines.