1.Pharmacometabolomics: Current Applications and Future Perspectives.
Translational and Clinical Pharmacology 2014;22(1):8-10
Metabolomics, a novel "omics" platform, is a powerful tool for the discovery of clinically useful biomarkers and biochemical processes to improve diagnosis and therapy. Through the use of advanced analytical technologies, metabolomics enables the assessment of comprehensive metabolic profiles that are affected by both genotype and environmental factors. Recently, attention has been focused on the concept of pharmacometabolomics, an emerging field that is derived from metabolomics. Pharmacometabolomics is focused on the use of individual metabolic signatures for the prediction and evaluation of drug efficacy and safety, eventually accelerating clinical pharmacology toward personalized drug therapy.
Biochemical Processes
;
Biomarkers
;
Diagnosis
;
Drug Therapy
;
Genotype
;
Humans
;
Precision Medicine
;
Metabolome
;
Metabolomics
;
Pharmacology, Clinical
2.The impact of large amount whole cow's milk intake on iron status in early childhood.
Sung Yoon BYUN ; Mi Ran PARK ; In Sang JEON
Journal of the Korean Pediatric Society 1993;36(7):968-974
To determine the impact of intake large amount whole cow's milk (WCM) on iron status during early childhood (18~36 months), selected indices of complete blood count(CBC) and iron status were compared between the WCM large amount intake group (n=20)and small amount intake group (n=20). WCM large amount intake children's mean hemoglobin and mean hematocrit were 9.6+/-1.7 g/dL and 30.8+/-4.5% respectively. These range of peripheral blood with other indices of CBC disclosed the hypochromic microcytic anemia. WCM large amount intake children's some indices of CBC-hemoglobin, hematocrit, MCV, MCH-were significantly lower than those of small amount intake children (P<0.01). WCM large amount intake children had significantly lower mean iron, transferrin saturation and ferritin (P<0.01) and greater mean total iron binding capacity (P<0.05) than did small amount intake children. It is concluded that intake large amount of WCM for long duration impacts on the iron status of 18~36 months old children disadvantageously. It should be avoided for the protection of irreversible recognitive impairment and behavioral change.
Anemia
;
Anemia, Iron-Deficiency
;
Child
;
Ferritins
;
Hematocrit
;
Humans
;
Iron*
;
Milk*
;
Transferrin
3.Regulation mechanisms of inflammatory response induced by Fc? stimulation in human monocytes and monocytic cell line, thp1.
Kang Soon YOON ; Suk Ran YOON ; Choong Eun LEE ; Hyung Soon KIM ; Kwang Ho PYUN
Korean Journal of Immunology 1993;15(2):163-171
No abstract available.
Cell Line*
;
Humans*
;
Monocytes*
4.The Factors Influencing on Health Promotion Behavior in Low-Income Vulnerable Elementary Students.
Journal of Korean Academy of Community Health Nursing 2008;19(2):167-176
PURPOSE: The goal of this study was to find out factors influencing the health promotion behavior of low-income vulnerable 4th, 5th and 6th-grade elementary school students. The specific goals were: first, to find out difference in health knowledge, self-esteem and health promotion behavior according to general characteristics; second, to investigate the correlations among health knowledge, self-esteem and health promotion; and, third, to analyze factors influencing health promotion behavior. METHODS: The subjects of this study were 137 low-income vulnerable 4th, 5th and 6th-grade elementary school children who were participating after-school programs in Seoul. RESULTS: Statistically significant differences were observed in health knowledge, self-esteem and health promotion behavior between girls and boys. In the sub categories, differences were observed in personal hygiene and health responsibility, stress management and personal relationship. The correlation of health promotion behavior with self-esteem and health knowledge was statistically significant. Regression analysis revealed that the influencing factor is self-esteem with the other variables under control. CONCLUSION: Health promotion education requires low-income vulnerable elementary children to increase their self-esteem. We recommend that it should be one of the most effective ways to split boys and girls to educate them in disparate classrooms.
Child
;
Education
;
Female
;
Fibrinogen
;
Health Promotion*
;
Humans
;
Hygiene
;
Seoul
;
Vulnerable Populations
5.Fatty acid oxidation disorders.
Hanyang Medical Reviews 2005;25(3):79-91
Inborn errors of fatty acid mitochondrial oxidation (FAOD) have drawn considerable attention in recent years because of rapid pace of discovery of new defects and an ever-increasing spectrum of clinical phenotypes. This review describes a clinical and biochemical phenotypes, diagnosis and treatment of FAOD. Some of FAOD can not be detected by conventional biochemical investigations, even when a patient is symptomatic with fasting intolerance or functional failure of fatty acid dependent tissue (s). Diagnosis must ultimately be based on direct assay of the involved enzyme, however, preliminary indicators may come from determination of carnitine and intermediate metabolites in plasma, profiling of urine organic acid, and radioisotopic screening assays with lymphocytes or cultured fibroblasts. We are faced with the following major challenges: whether to include FAOD in newborn screening programs, the investigation of the rules played by individual disorders in maternal complication during pregnancy, sudden and unexpected death in early life, and pediatric acute/fulminant liver failure.
Carnitine
;
Diagnosis
;
Fasting
;
Fibroblasts
;
Humans
;
Infant, Newborn
;
Liver Failure
;
Lymphocytes
;
Mass Screening
;
Phenotype
;
Plasma
;
Pregnancy
6.Intraventricular Hemorrhage in Full-Term Neonate.
Myoung Bae JEON ; Kook In PARK ; Choon Sik YOON ; Ran NAMGUNG ; Chul LEE ; Dong Gwan HAN
Journal of the Korean Pediatric Society 1994;37(6):776-785
Intraventricular hemorrhage is a common hemorrhagic cerebral disorder in premature, but occurs much less frequently in the full-term newborn. In order to obtain documentation of clinical and ultrasonographic characteristics of intraventricular hemorrhage in full-term, we performed cerebral ultrasonography on 602 newborn infants who had been admitted to neonatal intensive care unit at the Deppartment of Pediatrics, Yonsei University College of Medicine between December 1989 and June 1991. 15 cases (2.5%) of intraventricular hemorrhage were analysed. The results were as follows: 1) Among 15 cases with intraventricular hemorrhage, there was no obstetrical and perinatal complication in 8 cases (53%) and 13 cases (87%) were neurologically normal at birth. 2) Sudden onset of dramatic neurologic abnormalitis inclued seizures, fever, bulging fontanel, irritability, lethargy, vomiting in cases (73%) and the remainder (27%) had no clinical symptoms and signs. 3) The age at diangosis of hemorrhage was before 72 hours in 5 cases (33%), between 4 and 7 days in 2 cases (13%), at 8 to 28 days in 8 cases (53%), 8 of 15 cases (53%) had Grade 1 IVH, four with Grade 2, cases with Grade 3, and 1 case of these infant demonstrated Grade IV IVH. The source of hemorrhage was subependymal germinal matrix in 12 cases (80%) and choroid plaxus in 3 cases (20%). 4) Precipitating factors were cerebral venous infarction in 7 cases, hypoxic injury in 5, and 3 other infants had no identifiable medical risk factors. 5) Among all 15 survivors, 2 of 3 infants with choroid plexus hemorrhage required placement of a ventriculo-peritoneal shunt, in the other case, ventriculomegaly decreased spontaneously.
Choroid
;
Choroid Plexus
;
Hemorrhage*
;
Humans
;
Infant
;
Infant, Newborn*
;
Infarction
;
Intensive Care, Neonatal
;
Lethargy
;
Parturition
;
Pediatrics
;
Precipitating Factors
;
Risk Factors
;
Seizures, Febrile
;
Survivors
;
Ultrasonography
;
Ventriculoperitoneal Shunt
;
Vomiting
7.Erratum to: Screening newborns for metabolic disorders based on targeted metabolomics using tandem mass spectrometry.
Annals of Pediatric Endocrinology & Metabolism 2015;20(4):238-238
The original published article contains an inaccurate statement in Acknowledgements section.
8.Differentiation of human B lymphocytes by B cell stimulating cytokines.
Woo Jin NA ; Suk Ran YOON ; In Pyo CHOI ; Kwang Ho PYUN
Korean Journal of Immunology 1992;14(1):85-96
No abstract available.
B-Lymphocytes*
;
Cytokines*
;
Humans*
9.A Case of Multiple Xanthogranuloma in an Adult.
Sang Soon KIM ; Young Ran YOON ; Woo Young SIM ; Mu Hyoung LEE ; Choong Rim HAW
Korean Journal of Dermatology 1990;28(5):656-659
We report a case of multiple xanthogranuloma occurring ori the scalp in a 33 years old wornan. Multiple yellowish papules were developed on her scalp 3 months ago. Histopathologic findings showed massive granulomatous infiltrations of foamy histiocytes Touton giant cells in the dermis, and these cells were positive for lipid stain. This case was considered to be multiple xanthogranuloma in an adult, and treated by sur- gical excision.
Adult*
;
Dermis
;
Giant Cells
;
Histiocytes
;
Humans
;
Scalp
10.Serum Lipid Levels and Fatty Acid Metabolism in the Rat With Adriamycin Induced Cardiomyopathy.
Journal of the Korean Pediatric Society 2000;43(11):1480-1487
PURPOSE: Adriarnycin induced cardiomyopathy is irreversible and may procede to clinical congestive heart failure. Recently, it has been suggested that adriamycin may exert cardiomyopathy due to inhibition of transport across mitochondrial membranes rnediated by the carnitine palmitoyltransferase system(CPT I). The effect of adriamycin on fatty acid metabolisrn according to cumulative dose was not clarified. The purpose of this study was to ascertain the acute effect of adriamycin on lipid and fatty acid metabolism accoring to cumulative dose. METHODS: Sprague-Dawley rats were divided into two groups. The first group was control. The second group was given intraperitoneal injection with adriamycin(5mg/kg) twice a week for 2 weeks. Serum lipid (total cholesterol, triglyceride, HDL cholesterol, LDL cholesterol) and fatty acid levels were analyzed on the first day, 8th day, and 11th day after injection of adriamycin. RESULTS: Total cholesterol, triglyceride, and LDL cholesterol were significantly higher in adriamycin group compared to the control group. HDL cholesterol was similar in both groups. Total cholesterol and LDL choleterol level significantly increased over the adriamycin dose. Total fatty acid levels were significantly higher after injection of adriamycin. Long chain fatty acids such as palmitic acid, linoleic acicl and oleic acid levels were significantly elevated in the adriamycin group. CONCLUSION: Serum lipid and fatty acid levels increased significantly after injection of adriamycin.
Animals
;
Cardiomyopathies*
;
Carnitine O-Palmitoyltransferase
;
Cholesterol
;
Cholesterol, HDL
;
Cholesterol, LDL
;
Doxorubicin*
;
Fatty Acids
;
Heart Failure
;
Injections, Intraperitoneal
;
Metabolism*
;
Mitochondrial Membranes
;
Oleic Acid
;
Palmitic Acid
;
Rats*
;
Rats, Sprague-Dawley
;
Triglycerides