No abstract available.
Logistic Models*

BACKGROUND: Elevated plasma homocysteine level (tHcy) is one of the risk factors for coronary artery disease (CAD). It has been demonstrated that doses of folate as low as 0.25 mg/d significantly decreased tHcy in healthy, young women. Homozygosity for C-677T polymorphism in the Methylenetetrahydrofolate reductase (MTHFR) gene seems to be correlated with an elevated tHcy in the situation of low blood folate concentrations. In this study, we evaluated the response of the low dose folate treatment on the tHcy and whether genetic variation of MTHFR gene might influence the response of the folate treatment in korean CAD patients. METHODS: CAD patients (n=3), confirmed by coronary angiography, and controls were analyzed for CAD risk factors including tHcy and MTHFR gene C-677T polymorphism. Patients were treated with daily 0.25mg folate for 4weeks and the level of folate and tHcy was reevaluated. RESULTS: Low dose folate treatment for 4weeks significantly increased folate level (38%, p<0.05), but did not influence tHcy. Patients whose tHcy was decreased with folate replacement (n=1) were characterized by low basal folate level (7.0+/-2.6 vs 9.1+/-2.7 nmol/L, p<0.05) and high basal tHcy (12.6+/-4.4 vs 8.6+/-2.4 micromol/L, p<0.05) compared to the patients whose tHcy was unaffected or increased with folate. tHcy was decreased 11.2% and 12.6% each in patients with high basal tHcy (>10 micromol/L) and low folate level (<7 nmol/L), but increased 7.3% and 4.5% in patients with low tHcy and high folate level (p<0.05, each). MTHFR C-677T polymorphism was not a significant contributing factor for tHcy and for the response to folate treatment. CONCLUSION: Low dose folate treatment can decrease tHcy in CAD patients with low basal folate level and high basal tHcy. C-677T MTHFR gene mutation does not influence the effects of low dose folate treatment on tHcy in Korean CAD patients.
Coronary Angiography ; Coronary Artery Disease* ; Coronary Vessels* ; Female ; Folic Acid* ; Genetic Variation ; Homocysteine* ; Humans ; Methylenetetrahydrofolate Reductase (NADPH2) ; Plasma ; Risk Factors

1. In total 33 cases of cataract, measurements of the corneal curvature(radius) were performed preoperatively and postoperatively. 2. Among 6 cases of below 40 year old, extracapsular cataract extraction were 5 cases. While 23 cases were done in intracapsular extraction among 27 cases of more than 40 year. 3. At two month after the operation, vertical and horizontal curvatures are closer to that of preoperative condition than in 1 month after the operation. 4. 2 month after the operation, vertical curvatures are getting flat in 66 %, while more cases showed tight horizontal curvatures than flat one.
Adult ; Cataract Extraction ; Cataract* ; Humans

Sleep-related eating disorder (SRED) is a newly recognized parasomnia that describes a clinical condition of compulsive eating under an altered level of consciousness during sleep. Recently, it is increasingly recognized in clinical practice. The exact etiology of SRED is unclear, but it is assumed that SRED might share features of both sleepwalking and eating disorder. There have been also accumulating reports of SRED related to the administration of various psychotropic drugs, such as zolpidem, triazolam, olanzapine, and combinations of psychotropics. Especially, zolpidem in patients with underlying sleep disorders that cause frequent arousals, may cause or augment sleep related eating behavior. A thorough sleep history is essential to recognition and diagnosis of SRED. The timing, frequency, and description of food ingested during eating episodes should be elicited, and a history of concurrent psychiatric, medical, sleep disorders must also be sought and evaluated. Interestingly, dopaminergic agents as monotherapy were effective in some trials. Success with combinations of dopaminergic and opioid drugs, with the addition of sedatives, has also been reported in some case reports.
Arousal ; Benzodiazepines ; Consciousness Disorders ; Dopamine Agents ; Eating ; Feeding and Eating Disorders ; Feeding Behavior ; Humans ; Hypnotics and Sedatives ; Parasomnias ; Psychotropic Drugs ; Pyridines ; Sleep Wake Disorders ; Somnambulism ; Triazolam

No abstract available.
Hyperlipidemias*

No abstract available.

No abstract available.
Liver* ; Pathology*

In oder to determine values for the body weight by height groups for Korean adults men who are fully grown up 4028(30-39 age-group:2318, 40-49 age-group: 1340, and 50-59 age-group:370) apparently healthy males subjects were randomly selected for the measurement of body weight by height groups. 1) The average body height and weight of Korean adult men were 168.3+/-4.6cm and 63.4+/-7.1kg in 30-39 age group, 167.7+/-4.7cm and 63.4+/-7.4kg in 40-49 age group, and 167.3+/-5.2cm and 63.3+/-8.0kg in 50-59 age group. 2) A correlation coefficient of r=+0.52(P<0.001) between body height and weight was found in 30-39 ate group of 2318 subject, r=+0.48(P<0.001) in 40-49 of 1340 and r=+0.53(P<0.001) in 50-59 of 370 with the aid of there coefficients of linear regression body weight and height were established for male as follow; for 30-39 age group, Y(weight in kg)=0.81X(height in cm)-73.02, 40-49 age group, Y(weight in kg)=0.74X(height in cm)-61.82, 50-59 age group, Y(weight in kg)=0.82X(height in cm)-73.83. 3) With the aid of above listed various equation standard values for body weight by height group, with over weighing and under weighing values were established. 4) Standard bodyweight of Korean was lower than those of American, Japanese and several other formulas for ideal body weight.
Adult* ; Asian Americans ; Body Height ; Body Weight* ; Humans ; Ideal Body Weight ; Linear Models ; Male

No abstract available.

Dysplastic nodule (DN), which is nodular hepatocellular proliferation of at least 1mm in diameter, is detected most often through radiological and pathological observations in chronic advanced liver diseases. DNs characteristically contain portal tracts and they can be classified into low grade for mild atypia and high grade for at least moderate atypia that is insufficient for the diagnosis of malignancy. DNs are supplied portal venous blood and arterial blood supply. In unpaired arteries, new angiogenesis, shows stepwise increases in the following order of DN low grade, DN high grade, early hepatocellular carcinoma and hepatocellular carcinoma. There are convincing clinicopathological data to support the premise that DNs are considered to be precancerous lesions and early stages of multistep processes of hepatocellular carcinogenesis. Extensive clinicopathological and molecular study can provide a better understanding of the characteristics of DNs and new therapeutic approaches to DNs.
Arteries ; Carcinogenesis ; Carcinoma, Hepatocellular ; Diagnosis ; Liver Diseases ; Liver*