1.Minimally Invasive Surgery for Gastric Cancer.
Journal of the Korean Medical Association 2000;43(1):86-87
No abstract available.
Minimally Invasive Surgical Procedures*
;
Stomach Neoplasms*
2.Immunologic Characteristics of AIDS.
Journal of the Korean Pediatric Society 1986;29(8):1-6
No abstract available.
3.Insulin Resistance and Atherosclerosis.
Korean Circulation Journal 1997;27(8):817-819
No abstract available.
Atherosclerosis*
;
Insulin Resistance*
;
Insulin*
4.Prognostic Significance of Abnormal beta - catenin Expression in Breast Carcinoma.
Korean Journal of Pathology 2005;39(2):114-119
BACKGROUND: The subcellular localization and activity of beta-catenin are tightly regulated within the cell. The aim of this study was to analyze the aberrant beta-catenin expression in breast carcinomas and to determine its clinical significance. METHODS: Fifty five cases of breast carcinoma were immunostained with monoclonal antibodies against beta-catenin. Normal expression of -catenin was defined as exclusive membranous staining. Abnormal expression of beta-catenin was reclassified into 3 categories: complete or partial loss of membranous staining (LOM) without cytoplasmic staining and nuclear staining, LOM with cytoplasmic staining and without nuclear staining, and LOM with nuclear staining and with/without cytoplasmic staining. RESULTS: Normal membranous beta-catenin expression was detected in 25 (45.5%) of 55 cases of breast carcinoma. Thirty cases with abnormal -catenin expression comprised 9 cases (16.1%) showing LOM without cytoplasmic and/or nuclear staining, 20 cases (36.4%) showing LOM with cytoplasmic staining and without nuclear staining, and one case (1.8%) showing LOM with nuclear and cytoplasmic staining. Abnormal beta-catenin expression was significantly correlated with lymph node metastasis (p=0.03). LOM with cytoplasmic and/or nuclear expression was significantly correlated with poor disease free survival by univariate (p=0.03) and multivariate analyses (p=0.03). In addition, it was correlated with poor overall survival with a borderline significance (p=0.059). CONCLUSIONS: This study suggests that the cytoplasmic and/or nuclear expression of beta-catenin can be used as a biologic marker for predicting disease recurrence and poor patients' survival in breast carcinomas.
Antibodies, Monoclonal
;
beta Catenin
;
Biomarkers
;
Breast Neoplasms*
;
Breast*
;
Carcinoma, Ductal, Breast
;
Cytoplasm
;
Disease-Free Survival
;
Immunohistochemistry
;
Lymph Nodes
;
Multivariate Analysis
;
Neoplasm Metastasis
;
Recurrence
6.Cardiovascular disease in the elderly.
Korean Journal of Medicine 2001;60(6):503-506
7.Recent Advances in Pediatric Cardiology.
Journal of the Korean Pediatric Society 1987;30(11):1196-1200
No abstract available.
Cardiology*
8.The Applications of Biochips in Biomedical Fields.
Korean Journal of Clinical Microbiology 1999;2(2):114-117
No abstract available.
9.Antioxidant Use in Coronary Artery Disease.
Korean Circulation Journal 1998;28(4):658-662
No abstract available.
Coronary Artery Disease*
10.Postmortem Inspection of Asphyxial Death.
Journal of the Korean Medical Association 1998;41(3):250-254
No abstract available.