2.Antioxidant Use in Coronary Artery Disease.
Korean Circulation Journal 1998;28(4):658-662
No abstract available.
Coronary Artery Disease*
3.Postmortem Inspection of Asphyxial Death.
Journal of the Korean Medical Association 1998;41(3):250-254
No abstract available.
4.Postherpetic Neuralgia.
Journal of the Korean Medical Association 2001;44(3):315-324
No abstract available.
Neuralgia, Postherpetic*
5.The Applications of Biochips in Biomedical Fields.
Korean Journal of Clinical Microbiology 1999;2(2):114-117
No abstract available.
6.Recent Advances in Pediatric Cardiology.
Journal of the Korean Pediatric Society 1987;30(11):1196-1200
No abstract available.
Cardiology*
7.Insulin Resistance and Atherosclerosis.
Korean Circulation Journal 1997;27(8):817-819
No abstract available.
Atherosclerosis*
;
Insulin Resistance*
;
Insulin*
8.Prognostic Significance of Abnormal beta - catenin Expression in Breast Carcinoma.
Korean Journal of Pathology 2005;39(2):114-119
BACKGROUND: The subcellular localization and activity of beta-catenin are tightly regulated within the cell. The aim of this study was to analyze the aberrant beta-catenin expression in breast carcinomas and to determine its clinical significance. METHODS: Fifty five cases of breast carcinoma were immunostained with monoclonal antibodies against beta-catenin. Normal expression of -catenin was defined as exclusive membranous staining. Abnormal expression of beta-catenin was reclassified into 3 categories: complete or partial loss of membranous staining (LOM) without cytoplasmic staining and nuclear staining, LOM with cytoplasmic staining and without nuclear staining, and LOM with nuclear staining and with/without cytoplasmic staining. RESULTS: Normal membranous beta-catenin expression was detected in 25 (45.5%) of 55 cases of breast carcinoma. Thirty cases with abnormal -catenin expression comprised 9 cases (16.1%) showing LOM without cytoplasmic and/or nuclear staining, 20 cases (36.4%) showing LOM with cytoplasmic staining and without nuclear staining, and one case (1.8%) showing LOM with nuclear and cytoplasmic staining. Abnormal beta-catenin expression was significantly correlated with lymph node metastasis (p=0.03). LOM with cytoplasmic and/or nuclear expression was significantly correlated with poor disease free survival by univariate (p=0.03) and multivariate analyses (p=0.03). In addition, it was correlated with poor overall survival with a borderline significance (p=0.059). CONCLUSIONS: This study suggests that the cytoplasmic and/or nuclear expression of beta-catenin can be used as a biologic marker for predicting disease recurrence and poor patients' survival in breast carcinomas.
Antibodies, Monoclonal
;
beta Catenin
;
Biomarkers
;
Breast Neoplasms*
;
Breast*
;
Carcinoma, Ductal, Breast
;
Cytoplasm
;
Disease-Free Survival
;
Immunohistochemistry
;
Lymph Nodes
;
Multivariate Analysis
;
Neoplasm Metastasis
;
Recurrence
9.Cardiovascular disease in the elderly.
Korean Journal of Medicine 2001;60(6):503-506
10.Semmelweis's Work: Hand-washing Lowered Maternal Death Rate Dramatically.
Korean Journal of Nosocomial Infection Control 2005;10(2):43-47
Semmelweis correctly concluded that puerperal fever could be spread from necrotic discharge from living patients, as well as autopsy material. And maternal death rate was decreased dramatically by washing hands in chlorinated lime. Semmelweis may be credited with having for the first time constructed a statistically tested system of asepsis (keeping germs away from the patient) before the germ theory had arrived.
Asepsis
;
Autopsy
;
Fever
;
Hand
;
Humans
;
Maternal Death*
Result Analysis
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