Adult ; Histiocytosis, Langerhans-Cell ; Humans ; Male

Invasive fungal infections(IFI) is significantly increasing in the neonatal intensive care unit recent years.The characteristics of IFI are low diagnosis rate,high mortality and being prone to involve in the nervous system.In this paper,the epidemiology,pathogens,risk factors,diagnosis,treatment and prevention of neonatal IFI are reviewed to improve the understanding of this disease.

OBJECTIVE:To further perfect our Pharmaceutical Administration Law of PRC.METHODS:Contractive methods were used to analyze comparatively the legal liabilities in US FDCA and Pharmaceutical Administration Law of PRC with regard to awarding system for reporters,penalty terms and the disposition of the confiscated drugs.RESULTS&CON?CLUSION:Compared with the PRC Pharmaceutical Administration Law,the US FDCA is more comprehensive and more consummate.We should follow the legislative spirit in FDCA and take it as a reference to improve our Pharmaceutical Ad?ministration Law.

OBJECTIVE:To provide references for the establishment of drug recall system in China.METHODS: The drug recall system in U.S.A. was introduced so as to get some enlightenment for the drug safety in China.RESULTS & CONCLUSION: We could use the drug recall system in U.S.A. for references to improve our law criterion system and carry out drug recall system on a large scale.

Object To determine the change of benzoic acid contents in decoctions prepared from various combinations of the recipe named SIWUTANG by RP HPLC to provide a reference for the control of the acid level Methods 8 decoctions of P lactiflora either alone or in combination with one or more of the other 3 components, according to permutation and combination, were prepared and their benzoic acid contents determined by RP HPLC Results The content of benzoic acid in the decoction of Radix Paeonie Alba alone was found to be 2 74 mg/g, while that of the other 7 combinations varied from 0 41～1 11 mg/g Conclusion The content of benzoic acid in SIWUTANG could be lowered significantly by the presence of Radix Angelica Sinensis, Radix Rehmanniae, and Rhizoma Chuanxiong

BACKGROUND: Bone morphogenetic protein-2 is a high-efficient bone inducing factor, which can induce the inside and outside periosteum and marrow-derived stromal cells differentiate into osteoblast, strengthen the re generation of bone mattress, activate or lead MSCs around blood vessel to differentiate into chondroblast and osteoblast. OBJECTIVE: To observe the effects of yigu capsule to be used for pre vention and treatment on the expression of bone morphogenetic protein-2 in bone tissue of the ovariectomized rats with osteoporosis. DESIGN: A completely randomized grouping design and randomized con trol trial. SETTING: Department of Traditional Chinese Medicine, First Affiliated Hospital, Jinan University.MATERIALS: The experiment was carried out in the laboratory of Traditional Chinese Medicine of Jinan University form March to October 2003. Animals: 72 normal grand female SD rats, with 10-month-old ages, weighted (380±20) g, provided by the center of laboratory animal science of Guang dong (the quality exequatur number of No. 2002A024), were adopted. Totally 24 rats were randomly chosen from them anddivided into preventive group (12 rats) and therapeutic group (12 rats) of sham operation (only opened the rats' abdomen but not removed their ovary), and the left 48 rats were randomly divided into 4 groups after replicating OP model by ovariectomy (which opened the rats' abdomen and removed their ovary): OP model control group of prevention, OP model control group of treatment, OP model group of prevention with yigu capsule and OP model group of treatment with yigu capsule, with 12 rats in each group. Medicine: Yigu capsule was made up by epimedium, fruit of lycium barbaruml, radix angelica sinensis, root of achyranthes bidentata blume etc., the decoct-free granule of the drugs were provided by Shenzhen Sanjiu Medical & Pharmaceutical Co., Ltd, the aqueous solution was made to include crude drug 1.0 g/Ml. INTERVENTIONS: The prevented groups of yigu capsule were administered by gastric infusion 3 days after ovariectomy, 3 Ml NS was given to preventive group of sham operation and OP model control group and 3 Ml aqueous solution of yigu capsule was given to preventive group with yigu capsule,1 time a day for 24 weeks; the therapeutic groups of yigu capsule were administered by gastric infusion in the 13th week after ovariectomy, 3 Ml NS was given to therapeutic group of sham operation and OP model control group and 3 Ml aqueous solution of yigu capsule was given to therapeutic group with yigu capsule, 1 time a day for 12 weeks. Immunohistochemistry was used to detect the expression of BMP-2 on protein level in bone tissue. MAIN OUTCOME MEASURES: The mean gray (MG) of the BMP-2 positive reaction cells in bone tissue.RESLUTS: In the 24th week after ovariectomy, the MG of BMP-2 positive reaction cells in bone tissue of preventive OP model control group, preventive group with yigu capsule and preventive group of sham operation were 81.84±10.01, 124.46±6.55, 130.15±10.09, that of preventive OP model control group was obviously lower than that of preventive group of sham operation (P < 0.01), and that of preventive group with yigu capsule was obviously higher than that of preventive OP model control group (P < 0.01) and closed to that of preventive group of sham operation (P > 0.05). The MG of BMP-2 positive reaction cells in bone tissue of therapeutic OP model control group, therapeutic group with yigu capsule and therapeutic group of sham operation were 77.97±10.35, 110.32±8.69, 131.79±12.10, that of therapeutic OP model control group was obviously lower than that of therapeutic group of sham operation (P < 0.01), and that of therapeutic group with yigu capsule was obviously higher than that of therapeutic OP model control group (P < 0.01) and closed to that of therapeutic group of sham operation (P > 0.05). CONCLUSION: Thepreventive and therapeutic treatment of yigu capsule could both improve the expression of BMP-2 in bone tissue on albumen level.

Objective:To investigate the cesarean perioperative usage in patients, and the rationality of drug evaluation.Methods: A retrospective analysis in February 2012 to August 2013 in our hospital for treatment of cesarean perioperative clinical information on the use of antimicrobial agents for statistics, and use frequency analysis method for analysis.Results: All patients with the highest rates of antibiotic Ornidazole, the highest consumption of Ornidazole, the highest amount of sales Ornidazole, cefotiam, the highest frequency of drug use Ornidazole use reasonable potassium penicillin drugs, cefotiam, ornidazole; most unreasonable use drugs penicillin, cefazolin amount of sorting/DDDs (medication on the number) were higher than a sort; cefmetazole the amount of sorting/ DDDs (medication on the number) Sort lowest value, and less than 1.Ratio of only 0.56% monotherapy, combination therapy of two drugs highest proportion is 76.67%. Conclusion: Perioperative cesarean section used antibiotics exists that use a longer time, the problem of improper dosage should strengthen supervision and improve the rational use of medicines in hospitals level.

Objective To promote students health knowledge and behavior and to create work that would provide the basis for evaluating the health promoting school. Method In 102 of the health promoting schools, using cluster random sampling method, in each applied school last digit survey date was used as a random number, selected classes were investigated about the infectious disease, chronic disease, vaccination, emergencies and other items. The subjects of the investigation were totally 5 368 people, 2 673 girls, and 2 695 boys, including primary school students 2 848 (rural students 1 272, 1 576 urban), middle school students 2 520 (rural students 1 127, 1 393 urban). All the 5 368 questionnaires were returned, 5 366 were valid. Chi-square test was used to evaluate health knowledge awareness and behavior formation rate, P<0.05 was regarded as having statistical significance. Result Overall, the awareness rate of knowledge (84.5%) and behavior formation rate (76.5%) of girls were higher than those of boys (83.4%, 75.1%) (χ2=26.17, 13.23, P<0.05). The awareness rate of knowledge of primary school girls (83.1%) and their behavior formation rate (76.9%) were also higher than those of primary school boys (81.9%, 74.5%) (χ2=13.70, 21.58, P<0.05) city primary school students; knowledge rate (85%) and behavior formation rate (77.6%) of urban students were higher than those of rural students (80.2%, 74.1%) (χ2=226.99, 49.28, P<0.05). The awareness rate of knowledge of middle school girls (86.1%) was higher than that of middle school boys (85.1%) (χ2=9.73, P<0.05);awareness rate of knowledge (85.8%) of middle school urban students was higher than that of rural students (84.3%) (χ2=22.37, P<0.05). The awareness rate of silver and bronze school knowledge (84.0%, 84.0%) was higher than that of gold (80.6%) (χ2=19.02, 20.08, P<0.05);the gold medal school behavior formation rate (83.3%) was higher than that of silver and bronze school (76.2%, 75.4%) (χ2=30.57, 38.76, P<0.05), silverbehavior formation rate (76.2%) was higher than the that of bronze medal schools (75.4%) (χ2=3.99, P<0.05). Conclusion The school health promotion work is still focusing on health knowledge education stage, the awareness rates of knowledge and behavior formation rates are not completely consistent. Health promotion has not become a liability and the concept of the schools surveyed.

Objective:To investigate the value of myocardial velocity gradient(MVG) in diagnosis of myocardial ischemia.Methods:Thirty-eight patients with coronary artery disease and twenty-eight healthy volunteers were enrolled in this study,MVG-L+ in systolic stage and MVG-L-in diastolic stage were measured from apical four chamber and two chamber view.Results:In normal group,MVG-L+ and MVG-L-was slightly different among basal,middle and apical segments of left ventricular wall,which was no statistical difference.Compared with normal group,MVG-L+ and MVG-L-measured from myocardial ischemia group significantly decreased.Conclusion:MVG can quantitatively analyze the motional state of regional myocardium,alternatively providing an effective index of evaluating cardiac function in coronary artery disease.

Type 2 diabetes is associated with a marked increased risk of cardiovascular disease (CVD).Treatment for dyslipidemia in diabetes reduces cardiovascular event.This article reviewed the clinical trials of lipid lowering in diabetic subjects,treatment goals for lipoprotein therapy,and how to choose lipid lowering agents.