OBJECTIVE:To further perfect our Pharmaceutical Administration Law of PRC.METHODS:Contractive methods were used to analyze comparatively the legal liabilities in US FDCA and Pharmaceutical Administration Law of PRC with regard to awarding system for reporters,penalty terms and the disposition of the confiscated drugs.RESULTS&CON?CLUSION:Compared with the PRC Pharmaceutical Administration Law,the US FDCA is more comprehensive and more consummate.We should follow the legislative spirit in FDCA and take it as a reference to improve our Pharmaceutical Ad?ministration Law.

OBJECTIVE:To provide references for the establishment of drug recall system in China.METHODS: The drug recall system in U.S.A. was introduced so as to get some enlightenment for the drug safety in China.RESULTS & CONCLUSION: We could use the drug recall system in U.S.A. for references to improve our law criterion system and carry out drug recall system on a large scale.

Invasive fungal infections(IFI) is significantly increasing in the neonatal intensive care unit recent years.The characteristics of IFI are low diagnosis rate,high mortality and being prone to involve in the nervous system.In this paper,the epidemiology,pathogens,risk factors,diagnosis,treatment and prevention of neonatal IFI are reviewed to improve the understanding of this disease.

Adult ; Histiocytosis, Langerhans-Cell ; Humans ; Male

Object To determine the change of benzoic acid contents in decoctions prepared from various combinations of the recipe named SIWUTANG by RP HPLC to provide a reference for the control of the acid level Methods 8 decoctions of P lactiflora either alone or in combination with one or more of the other 3 components, according to permutation and combination, were prepared and their benzoic acid contents determined by RP HPLC Results The content of benzoic acid in the decoction of Radix Paeonie Alba alone was found to be 2 74 mg/g, while that of the other 7 combinations varied from 0 41～1 11 mg/g Conclusion The content of benzoic acid in SIWUTANG could be lowered significantly by the presence of Radix Angelica Sinensis, Radix Rehmanniae, and Rhizoma Chuanxiong

ObjectiveTo explore the clinical effect of fiberoptic bronchoscope on mechanical ventilation patients with lung infection. Methods42 patients with serious lung infection acted mechanical ventilation were carried by fiberoptic bronchscope to check airstract,clear the waset,waste cultivating,and lung washing. ResultsThe waste cultivating was Positive. The conditions of 39 patients were improved effectively. The PaO2 ( t =-188. 539, P ＜0. 001 ), PaCO2 ( t =74. 481, P ＜ 0. 001 ), SaO2 ( t =-9. 025, P ＜ 0. 001 ) were statistically different after fiberoptic bronchoscope treatment. ConclusionFiberoptic bronchoscope could effectively identify the etiology and provide specif.ic antiinflamation treatment ;lung washing was beneficial for the airabstract waste extraction to improve the condition which was a relatively safe and effective method.

ObjectiveTo explore the mechanisms of proliferation and apoptosis of K562 cells induced by cytarabine. MethodsDifferent doses of cytarabine on the proliferotion at K562 cell 24h,48h,72h were detected by MTT. Cell cycle And Apoptosis rate were detected by FCM. ResultsEach concentration of cytarabine obvious inhibited the growth of K562 cells. In the same concentrations,function of proliferation inhibition with cytarabine increased by the extension of time,which showed dose and time effect relations. Cytarabine on K562 cell,G0/G1 phase cell proportion of role as cytarabine increased when extension of time, S period and the G2/M period cells were decreased.Apoptosis of K562 cell in proportion as drug concentration and effect time increases, which present Cytarabine timeconcentration dependence. CondusionCytarabine was apparent inhibition to proliferation of K562 cell leukemia cell, which could promote K562 cell apoptosis by time and concentration dependence way.

BACKGROUND: Bone morphogenetic protein-2 is a high-efficient bone inducing factor, which can induce the inside and outside periosteum and marrow-derived stromal cells differentiate into osteoblast, strengthen the re generation of bone mattress, activate or lead MSCs around blood vessel to differentiate into chondroblast and osteoblast. OBJECTIVE: To observe the effects of yigu capsule to be used for pre vention and treatment on the expression of bone morphogenetic protein-2 in bone tissue of the ovariectomized rats with osteoporosis. DESIGN: A completely randomized grouping design and randomized con trol trial. SETTING: Department of Traditional Chinese Medicine, First Affiliated Hospital, Jinan University.MATERIALS: The experiment was carried out in the laboratory of Traditional Chinese Medicine of Jinan University form March to October 2003. Animals: 72 normal grand female SD rats, with 10-month-old ages, weighted (380±20) g, provided by the center of laboratory animal science of Guang dong (the quality exequatur number of No. 2002A024), were adopted. Totally 24 rats were randomly chosen from them anddivided into preventive group (12 rats) and therapeutic group (12 rats) of sham operation (only opened the rats' abdomen but not removed their ovary), and the left 48 rats were randomly divided into 4 groups after replicating OP model by ovariectomy (which opened the rats' abdomen and removed their ovary): OP model control group of prevention, OP model control group of treatment, OP model group of prevention with yigu capsule and OP model group of treatment with yigu capsule, with 12 rats in each group. Medicine: Yigu capsule was made up by epimedium, fruit of lycium barbaruml, radix angelica sinensis, root of achyranthes bidentata blume etc., the decoct-free granule of the drugs were provided by Shenzhen Sanjiu Medical & Pharmaceutical Co., Ltd, the aqueous solution was made to include crude drug 1.0 g/Ml. INTERVENTIONS: The prevented groups of yigu capsule were administered by gastric infusion 3 days after ovariectomy, 3 Ml NS was given to preventive group of sham operation and OP model control group and 3 Ml aqueous solution of yigu capsule was given to preventive group with yigu capsule,1 time a day for 24 weeks; the therapeutic groups of yigu capsule were administered by gastric infusion in the 13th week after ovariectomy, 3 Ml NS was given to therapeutic group of sham operation and OP model control group and 3 Ml aqueous solution of yigu capsule was given to therapeutic group with yigu capsule, 1 time a day for 12 weeks. Immunohistochemistry was used to detect the expression of BMP-2 on protein level in bone tissue. MAIN OUTCOME MEASURES: The mean gray (MG) of the BMP-2 positive reaction cells in bone tissue.RESLUTS: In the 24th week after ovariectomy, the MG of BMP-2 positive reaction cells in bone tissue of preventive OP model control group, preventive group with yigu capsule and preventive group of sham operation were 81.84±10.01, 124.46±6.55, 130.15±10.09, that of preventive OP model control group was obviously lower than that of preventive group of sham operation (P < 0.01), and that of preventive group with yigu capsule was obviously higher than that of preventive OP model control group (P < 0.01) and closed to that of preventive group of sham operation (P > 0.05). The MG of BMP-2 positive reaction cells in bone tissue of therapeutic OP model control group, therapeutic group with yigu capsule and therapeutic group of sham operation were 77.97±10.35, 110.32±8.69, 131.79±12.10, that of therapeutic OP model control group was obviously lower than that of therapeutic group of sham operation (P < 0.01), and that of therapeutic group with yigu capsule was obviously higher than that of therapeutic OP model control group (P < 0.01) and closed to that of therapeutic group of sham operation (P > 0.05). CONCLUSION: Thepreventive and therapeutic treatment of yigu capsule could both improve the expression of BMP-2 in bone tissue on albumen level.

Objective To observe the clinical efficacy of glutathione(GSH)to reduce hepatic involvement of statin therapy patients with hepatitis B markers positive.Methods 164 cases with hepatitis B markers positive were selected and divided into the treatment group(82 cases)and control group(82 cases).In a statin therapy with primary disease,at the same time,the control group using based protect liver therapy(both inosine,vitamin C),the treatment group using reduced glutathione intravenous drip(1.2g,one/d).After 12 weeks,the liver function was examined.Results Patients taking statins ALT,TB and DB levels obviously higher than before,had a statistically significant difference(t=2.66,1.98,2.13,P＜0.05),the differences of observation index level in treatment group before and after treatment had no statistical difference(P＞0.05),12 patients(14.6％)ALT level in treatment group were more than normal,0 case more than normal limit 3 times,control group respectively for 23 cases(28.1％),3 cases(3.7％),two groups had statistically significant difference(x2=4.672,5.304,all P＜0.05).Conclusion GSH can obviously reduce hepatic involvement of statin therapy patients with hepatitis B markers positive.

OBJECTIVE： To discuss the severe challanges confronted by pharmaceutical business of China after WTO entry.METHODS： Starting with the current situation of pharmaceutical business of China， we analysed the influence exerted by the entry of foreign merchants or foreign captial into our pharmaceutical business.RESULTS ＆ CONCLUSION： In the near future， WTO entry will certainly produce a great impact on pharmaceutical business of China and will affect its survival and development in the extensive and intensive competition of international marketing.We should be fully aware of the situation that we confront with and consider countermeasure at an early date.