Adult ; Histiocytosis, Langerhans-Cell ; Humans ; Male

OBJECTIVE:To further perfect our Pharmaceutical Administration Law of PRC.METHODS:Contractive methods were used to analyze comparatively the legal liabilities in US FDCA and Pharmaceutical Administration Law of PRC with regard to awarding system for reporters,penalty terms and the disposition of the confiscated drugs.RESULTS&CON?CLUSION:Compared with the PRC Pharmaceutical Administration Law,the US FDCA is more comprehensive and more consummate.We should follow the legislative spirit in FDCA and take it as a reference to improve our Pharmaceutical Ad?ministration Law.

OBJECTIVE:To provide references for the establishment of drug recall system in China.METHODS: The drug recall system in U.S.A. was introduced so as to get some enlightenment for the drug safety in China.RESULTS & CONCLUSION: We could use the drug recall system in U.S.A. for references to improve our law criterion system and carry out drug recall system on a large scale.

Invasive fungal infections(IFI) is significantly increasing in the neonatal intensive care unit recent years.The characteristics of IFI are low diagnosis rate,high mortality and being prone to involve in the nervous system.In this paper,the epidemiology,pathogens,risk factors,diagnosis,treatment and prevention of neonatal IFI are reviewed to improve the understanding of this disease.

Object To determine the change of benzoic acid contents in decoctions prepared from various combinations of the recipe named SIWUTANG by RP HPLC to provide a reference for the control of the acid level Methods 8 decoctions of P lactiflora either alone or in combination with one or more of the other 3 components, according to permutation and combination, were prepared and their benzoic acid contents determined by RP HPLC Results The content of benzoic acid in the decoction of Radix Paeonie Alba alone was found to be 2 74 mg/g, while that of the other 7 combinations varied from 0 41～1 11 mg/g Conclusion The content of benzoic acid in SIWUTANG could be lowered significantly by the presence of Radix Angelica Sinensis, Radix Rehmanniae, and Rhizoma Chuanxiong

BACKGROUND: Bone morphogenetic protein-2 is a high-efficient bone inducing factor, which can induce the inside and outside periosteum and marrow-derived stromal cells differentiate into osteoblast, strengthen the re generation of bone mattress, activate or lead MSCs around blood vessel to differentiate into chondroblast and osteoblast. OBJECTIVE: To observe the effects of yigu capsule to be used for pre vention and treatment on the expression of bone morphogenetic protein-2 in bone tissue of the ovariectomized rats with osteoporosis. DESIGN: A completely randomized grouping design and randomized con trol trial. SETTING: Department of Traditional Chinese Medicine, First Affiliated Hospital, Jinan University.MATERIALS: The experiment was carried out in the laboratory of Traditional Chinese Medicine of Jinan University form March to October 2003. Animals: 72 normal grand female SD rats, with 10-month-old ages, weighted (380±20) g, provided by the center of laboratory animal science of Guang dong (the quality exequatur number of No. 2002A024), were adopted. Totally 24 rats were randomly chosen from them anddivided into preventive group (12 rats) and therapeutic group (12 rats) of sham operation (only opened the rats' abdomen but not removed their ovary), and the left 48 rats were randomly divided into 4 groups after replicating OP model by ovariectomy (which opened the rats' abdomen and removed their ovary): OP model control group of prevention, OP model control group of treatment, OP model group of prevention with yigu capsule and OP model group of treatment with yigu capsule, with 12 rats in each group. Medicine: Yigu capsule was made up by epimedium, fruit of lycium barbaruml, radix angelica sinensis, root of achyranthes bidentata blume etc., the decoct-free granule of the drugs were provided by Shenzhen Sanjiu Medical & Pharmaceutical Co., Ltd, the aqueous solution was made to include crude drug 1.0 g/Ml. INTERVENTIONS: The prevented groups of yigu capsule were administered by gastric infusion 3 days after ovariectomy, 3 Ml NS was given to preventive group of sham operation and OP model control group and 3 Ml aqueous solution of yigu capsule was given to preventive group with yigu capsule,1 time a day for 24 weeks; the therapeutic groups of yigu capsule were administered by gastric infusion in the 13th week after ovariectomy, 3 Ml NS was given to therapeutic group of sham operation and OP model control group and 3 Ml aqueous solution of yigu capsule was given to therapeutic group with yigu capsule, 1 time a day for 12 weeks. Immunohistochemistry was used to detect the expression of BMP-2 on protein level in bone tissue. MAIN OUTCOME MEASURES: The mean gray (MG) of the BMP-2 positive reaction cells in bone tissue.RESLUTS: In the 24th week after ovariectomy, the MG of BMP-2 positive reaction cells in bone tissue of preventive OP model control group, preventive group with yigu capsule and preventive group of sham operation were 81.84±10.01, 124.46±6.55, 130.15±10.09, that of preventive OP model control group was obviously lower than that of preventive group of sham operation (P < 0.01), and that of preventive group with yigu capsule was obviously higher than that of preventive OP model control group (P < 0.01) and closed to that of preventive group of sham operation (P > 0.05). The MG of BMP-2 positive reaction cells in bone tissue of therapeutic OP model control group, therapeutic group with yigu capsule and therapeutic group of sham operation were 77.97±10.35, 110.32±8.69, 131.79±12.10, that of therapeutic OP model control group was obviously lower than that of therapeutic group of sham operation (P < 0.01), and that of therapeutic group with yigu capsule was obviously higher than that of therapeutic OP model control group (P < 0.01) and closed to that of therapeutic group of sham operation (P > 0.05). CONCLUSION: Thepreventive and therapeutic treatment of yigu capsule could both improve the expression of BMP-2 in bone tissue on albumen level.

OBJECTIVE： To discuss the severe challanges confronted by pharmaceutical business of China after WTO entry.METHODS： Starting with the current situation of pharmaceutical business of China， we analysed the influence exerted by the entry of foreign merchants or foreign captial into our pharmaceutical business.RESULTS ＆ CONCLUSION： In the near future， WTO entry will certainly produce a great impact on pharmaceutical business of China and will affect its survival and development in the extensive and intensive competition of international marketing.We should be fully aware of the situation that we confront with and consider countermeasure at an early date.

Gonadotropin releasing hormone agonists(GnRHa)are the relatively safe drugs widely used in clinic to treat precocious puberty.After therapy withdrawal,the patients would have normal menstrual onset,gestation and fertility.GnRHa didn't degrade uterus volume of post puberty.After cessation of GnRHa,luteinizing hormone,follicle stimulating hormone and sex hormone levels would return to those before therapy,or even exceed them.Some researches suggested that gonadotropin releasing hormone analogue might increase the risk of androgen excess and polycystic ovary syndrome.The researches apply no sufficient evidences to show that GnRHa had significant and irreversible negative influences on bone mineral density.GnRHa might have the side effect of increasing body mass index(BMI).However,researches also showed that GnRHa was helpful to decrease BMI,or not to increase it.

Nijmegen breakage syndrome (NBS) is a rare autosomal recessive disorder. Epidemiological data evidence that NBS1 gene can be considered a susceptibility factor for cancer development.So far nine mutations localized in coding sequence of the NBS1 gene have been found at the heterozygous state in cancer patients,the 6S7del5,511A→C (I171V), 643C→T(R215W) are the most frequently described. The review will focus on the symptoms of NBS characteristics, the recent advances of NBS1 gene producethe correlation between carriers of NBS1 gene frequent heterozygous mutations and the development of malignant tumours.

The character, classification, scoring, diagnosis and treatment of abdominal injuries after the Wenchuan earthquake were analyzed based on the data collected in Chengdu and Dujiangyan. Most of the abdominal injuries were closed injury, and complicated with injuries in other organs. All the injured persons were classified into different groups according to the degree of injuries, so as to determine the optimal sequence of treatment. Open abdominal injuries were comparatively easy to diagnose, while the diagnosis of closed abdominal injuries was difficult and consisted of preoperative diagnosis and intraoperatire exploration. The principle of damage control surgery should be well followed in rescuing the persons with severe abdominal injuries.