ObjectiveTo discuss the relationship between serum homocysteine (Hcy) level and severity of acute coronary syndrome(ACS) through measuring the level of serum Hey in the patients with ACS.Methods95 patients who were diagnosed ACS were divided into two groups:40 cases of unstable angina(UA) and 55 cases of a cute myocardial infarction(AMI).30 individuals were chosen as normal control(NC).In addition,according to the results of coronary angiography,the same 95 patients were further divided into three subgroups which were single-vessel disease( 28cases),double-vessel disease ( 36cases ) and multi-vessel disease ( 31 cases ).Level of serum Hcy was measured in all groups.ResultsSerum Hcy level of ACS patients was significantly higher than NC group( P ＜ 0.01 ).The level of serum Hcy in AMI group was significantly higher than that in UA group( P ＜ 0.05 ).The Hcy level in the multi-vessel disease group,double-vessel disease group and single-vessel disease group were increased in turn,and the difference of pairwise comparison was statistically significant ( P ＜ 0.05 ).ConclusionThe serum Hcy level has rela tionship with the severity of coronary lesions and is directly proportional to the number of coronary artery lesions.The result suggests that the level of serum Hcy maybe play an important role in the prevention,diagnosis,treatment and monitoring of ACS.

Diagnosis, Differential ; Drugs, Chinese Herbal ; therapeutic use ; Humans ; Medicine, Chinese Traditional ; Neoplasms ; diagnosis ; drug therapy ; Phytotherapy ; Quality of Life ; Treatment Outcome

Objective To investigate the effect of intensive nursing intervention on the secondary infection in chemotherapy of elderly patients with lung cancer.Methods 168 cases of elderly lung cancer patients whose neutrophil ≤ 1.0×109/L during chemotherapy were randomly divided into two groups,namely,the intensive care group and the control group,with 84 cases in each group.The control group was given routine nursing of infection prevention,while the intensive care group was given intensified nursing for infection prevention.A contrastive analysis was conducted in terms of the incidence,clinical characteristics and the duration of antibiotic treatment of the two groups of patients with secondary infection.Results The secondary infection rate of the intensive care group was lower than that of the control group during chemotherapy.What's more,the duration of fever and treatment of the intensive care group was shorter than that of the control group,hence the patients were safe during infection period.The difference was statistically significant.Conclusions Strengthening the nursing intervention can reduce the incidence rate of secondary infection in aged patients with lung cancer,increase the tolerance of patients to chemotherapy and ensure the successful completion of the chemotherapy cycle,prolong the life span of the patients with an improved quality of life.

Child, Preschool ; Facial Paralysis ; etiology ; Female ; Hand, Foot and Mouth Disease ; complications ; drug therapy ; Humans

Fibrosis ; Humans ; Integrative Medicine ; Liver Cirrhosis ; diagnosis

Humans ; Liver Cirrhosis

Anal Canal ; surgery ; Humans ; Postoperative Complications ; Rectal Neoplasms ; surgery

Bladder cancer is the most common malignant tumor in urogenital system. Bladder carcinoma has the biological characteristics of easy recurrence and metastasis. The cancer stem cells theory explained the mechanisms of bladder cancer recurrence and metastasis. Epithelial-mesenchymal transition ( EMT) could promote tumor cells to acquire stem cell characteristics, while the tumor cells with stem cell characteristics have correspondingly high expression of EMT biomarkers. Long noncoding RNA ( lncRNA) promotes tumor cells to acquire and maintain stem cell characteristics through regulating EMT process. CSCs, EMT and lncRNA are closely related to the genesis and development of tumors, and participate in the regulation process of tumor proliferation, invasion, me-tastasis and so on. It will provide new insights in targeting therapy of tumor metastasis and recurrence through illuminating the correla-tion between lncRNA on EMT of bladder cancer stem cells ( BCSCs) This article makes a review on the latest research progress about the mechanism of lncRNA regulating EMT of BCSCs.

Objective:To investigate the effect of the ERK1/2 signal-transduction pathway on differentiation of rat mesencephalic neural stem cells(NSCs)in presence of bone marrow stromal cell-conditioned medium(BMSCs-CM)in vitro.Methods:NSCs were cultured on poly-L-lysine(PLL)coated 35 mm dishes.The neurospheres adhered to the bottom 30 min later;then the culture medium of natural differentiation group was replaced by neurobasal medium containing 2% B27;the control group was replaced with BMSCs- CM;and the inhibition group was replaced with BMSCs-CM containing PD98059(5?mol/L).The proportions of neurons and astrocytes and their morphological difference were observed by immunocytochemistry technique 7 d later.Results:We successfully cultured NSCs from adult rat BMSCs-CM.The proportion of neurons in the natural differentiation group(15.70?10.3)% was lower than that in the control group([51.17?10.30]%,P

0.05). conclusion; The frequency of A allele in essential hypertension is higher than that in control group, but there is no statistical significance. The relationship between AT2R gene A1675G polymorphism and essential hypertensive patients of the Chinese Han nationality population.