1.Fine Needle Aspiration Cytology of Pulmonary Hamartoma: 3 cases.
Na Hye MYONG ; Kyung Ja CHO ; Ja June JANG
Korean Journal of Pathology 1989;23(3):355-358
Fine needle aspiration cytology of three cases of pulmonary hamartoma is presented. Case 1 was in a 67-year-old man with a 7 cm-sized left lung mass. Case 2 and 3 were in 47 and 53 year old females and consisted of 3 cm and 2 cm-sized right lung nodules, respectively. Fine needle aspiration of the masses revealed several fragments of irregularly shaped mature hyaline cartilage or fibromyxoid mesenchyme and sheets of benign epithelial cells in scanty to acellular background. Also scattered were inflammatory cells including lymphocytes, neutrophils and histiocytes and mature fat cells. These features were diagnostic for pulmonary hamartoma and case 1 was histologically confirmed by following surgical excision of the mass. Differential diagnoses about pulmonary hamartoma in the respect of conditions capable of producing cartilage on fine needle aspiration, were discussed.
Female
;
Male
;
Humans
;
Diagnosis, Differential
;
Hamartoma
2.One Case of Acute Werdnig-Hoffmann Disease.
Do Keum NA ; Kyung Sook CHO ; Jonh Dae JO
Journal of the Korean Pediatric Society 1983;26(5):510-515
No abstract available.
Spinal Muscular Atrophies of Childhood*
3.The effects of differentiation and glucocorticoid treatment on the expression of lipocortin 1 in U937 cells.
Young Joo CHO ; Hee Bom MOON ; Do Sun NA
Korean Journal of Allergy 1997;17(2):119-128
Lipocortin represents a family of similar Ca++ depentent phospholipid-binding proteins capable of blocking the activity of phospholipase A2 (PLA2) in vitro. Generally, these proteins are believed to inhibit the release of arachidonic acid from photopholipids and the formation of lipid mediators such as prostaglandin, leukotriene, and platelet activating factor. Lipocortin 1, initially identified as a glucocorticoid- responsive protein in macrophages and neutrophils has been implicated in transmembrane signal transduction during growth factor-mediated cell proliferation and transformation. To define the synthesis and its regulation, we investigated the expression of lipocortin 1 in both the mRNA and protein level in U937 cell line in the presence of several differentiation factors. The results were as follows. 1. The expression of lipocortin 1 and its mRNA was increased during TPA-induced differentiation of U937 cells to maximum of 2-fold and 5-fold respectively. Both the protein and mRNA levels decreased after 48 hours. 2. With the treatment with IFN-gamma, the expression of CD16 was increased. However, the protein and mRNA levels of lipocortin 1 were, not changed significantly. 3. Neither the dexamethasone or hydrocortisone have any effects on the expression of lipocortin 1 in both TPA-differentiated and undifferentiated U937 cells. The results from this study would give a light on defining the functional role of lipocortin 1 in macro-moncycle cell lineage and possibly some informative clues for the pathogenic mechanisms of the inflammatory diseases.
Annexin A1*
;
Annexins*
;
Arachidonic Acid
;
Cell Lineage
;
Cell Proliferation
;
Dexamethasone
;
Humans
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Hydrocortisone
;
Macrophages
;
Neutrophils
;
Phospholipases A2
;
Platelet Activating Factor
;
RNA, Messenger
;
Signal Transduction
;
U937 Cells*
4.Comparing Two Diagnostic Laboratory Tests for Several Microdeletions Causing Mental Retardation Syndromes: Multiplex Ligation-Dependent Amplification vs Fluorescent In Situ Hybridization.
Eun Hae CHO ; Bo Ya Na PARK ; Jung Hee CHO ; You Sun KANG
The Korean Journal of Laboratory Medicine 2009;29(1):71-76
BACKGROUND: Microdeletion syndromes not detectable by conventional cytogenetic analysis have been reported to occur in approximately 5% of patients with unexplained mental retardation (MR). Therefore, it is essential to ensure that patients with MR are screened for these microdeletion syndromes. Mental retardation syndrome multiplex ligation-dependent probe amplification (MRS-MLPA) is a new technique for measuring sequence dosages that allows for the detection of copy number changes of several microdeletion syndromes (1p36 deletion syndrome, Williams syndrome, Smith-Magenis syndrome, Miller-Dieker syndrome, DiGeorge syndrome, Prader-Willi/Angelman syndrome, Alagille syndrome, Saethre-Chotzen syndrome, and Sotos syndrome) to be processed simultaneously, thus significantly reducing the amount of laboratory work. METHODS: We assessed the performance of MLPA (MRC-Holland, The Netherlands) for the detection of microdeletion syndromes by comparing the results with those generated using FISH assays. MLPA analysis was carried out on 12 patients with microdeletion confirmed by FISH (three DiGeorge syndrome, four Williams syndrome, four Prader-Willi syndrome, and one Miller-Dieker syndrome). RESULTS: The results of MLPA analysis showed a complete concordance with FISH in 12 patients with microdeletion syndromes. CONCLUSIONS: On the basis of these results, we conclude that MLPA is an accurate, reliable, and cost-effective alternative to FISH in the screening for microdeletion syndromes.
*Chromosome Deletion
;
Classical Lissencephalies and Subcortical Band Heterotopias/genetics
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DiGeorge Syndrome/genetics
;
Humans
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In Situ Hybridization, Fluorescence/*methods
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Laboratories, Hospital
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Mental Retardation/*diagnosis/genetics
;
Nucleic Acid Amplification Techniques/*methods
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Prader-Willi Syndrome/genetics
;
Williams Syndrome/genetics
5.Development and Effects' Analysis of Nutrition Education Pamphlet for the Lower Grades Elementary Students -Focused on Individual Daily Needed Food Exchange Units-.
Min Jung SON ; Young Sook CHO ; Se Na KIM ; Hye Ji SEO ; Sook Bae KIM
Korean Journal of Community Nutrition 2011;16(6):647-660
The purpose of this study was to investigate effects of nutrition education program and pamphlet for the lower grades elementary students focused on individual daily needed food exchange units using Food Exchange System. Program consisted of four lessons (40 min/lesson), "5 major nutrients & function", "6 food group and sources", "daily needed food exchange units for normal body weight", and "smart snack choice and exercise". Pamphlet as activity book was developed for the program. The subjects were 3rd grade elementary students (educated group, 31 vs. non-educated group, 31). Educated group were lessoned as group and/or individual. We examined the differences in nutrition knowledge, dietary attitudes, dietary intakes and satisfaction of the program and pamphlet. In educated group, there were positive improvements on nutrition knowledge score "function and foods of 5 nutrients" and on dietary attitudes "type of breakfast and snacks". In the evaluation of dietary intakes according to KDRI, there were positive improvements on intakes level of riboflavin, vit. C, folate, Ca, P, Fe and Zn in educated group. In satisfaction with the program and pamphlet, contents, font size, visual, figure, difficulty and program curriculum were over 2.90/3.0. It showed that the developed nutrition education program and pamphlet focused on individual daily needed food exchange units using Food Exchange System improved nutrition knowledge, dietary attitudes and nutrients intake level in the lower grades elementary students.
Breakfast
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Curriculum
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Folic Acid
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Humans
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Pamphlets
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Riboflavin
;
Snacks
6.A study on the mutual interactions of atherosclerotic risk factors:results from employee pediatric health examinations.
Mi Na NHA ; Hee Cheol OH ; You Lan PYEON ; Jeong Jin CHO
Journal of the Korean Academy of Family Medicine 1992;13(2):140-151
No abstract available.
7.Comparison of Learning Effects using High-fidelity and Multi-mode Simulation: An Application of Emergency Care for a Patient with Cardiac Arrest.
Eon Na RYOO ; Eun Ho HA ; Jin Young CHO
Journal of Korean Academy of Nursing 2013;43(2):185-193
PURPOSE: Simulation-based learning has become a powerful method to improve the quality of care and help students meet the challenges of increasingly complex clinical practice settings. The purpose of this study was to identify the learning effects using high-fidelity SimMan and multi-mode simulation. METHODS: Participants in this study were 38 students who were enrolled in an intensive course for a major in nursing at R college. Collected data were analyzed using Chi-square, t-test, and independent t-test with the SPSS 18.0 for Windows Program. RESULTS: There were no statistically significant differences in learning effects between high-fidelity SimMan and multi-mode simulation group. However, skills in clinical performance in the high-fidelity SimMan group were higher than in the multi-mode group (p=.014), communication in clinical performance in multi-mode simulation group was higher than in the high-fidelity SimMan group (p<.001). CONCLUSION: Multi-mode simulation with a standardized patient is an effective learning method in many ways compared to a high-fidelity simulator. These results suggest that multi-mode simulation be offered to students in nursing colleges which cannot afford to purchase a high-fidelity simulator, or offered as an alternative.
Adult
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Education, Nursing, Baccalaureate
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Emergency Medical Services
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Female
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Heart Arrest/*nursing
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Humans
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Learning
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Male
;
Manikins
;
*Patient Simulation
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Students, Nursing/psychology
8.Cellular Blue Nevus: A case report.
Na Hye MYONG ; Je G CHI ; Byung Kyu CHO ; Kye Yong SONG
Korean Journal of Pathology 1993;27(5):542-545
Cellular blue nevus is an benign variant of blue nevus group, characterized by cellular islands composed of closely aggregated spindle cells with little or no melanin. The other variants include atypical and malignant blue nevus which often had the difficulties in the differential diagnosis from the malignant melanoma. A 4-year-old boy presented with hemispheric scalp nodule, which has been slowly grown since birth, measuring 3.5x3x1.5 cm. The surface showed geographic black pigmentation without hairs, hemorrhage, and ulceration. The excised mass disclosed homogeneoulsy dark black, glistening, and muddy cut surface. Histological examination revealed exuberant melanocytic proliferation with both spindle and dendritic components. Heavily pigment ed spindle cells, melanophages, focal necrosis, and vacuolated epithelioid cells were unusually noted in our case and diagnosed as cellular blue nevus. Electron microscopy disclosed largely mature melanosomes in tumor cells and melanophages. During about 16 months since operation, he has been relatively well with no evidence of disease.
Diagnosis, Differential
9.A Case of Suspected Post-Irradiation Delayed Necrotizing Leukoencephalopathy.
Jeong Gyun NA ; Won Young JUNG ; Kyung Won CHO
Journal of the Korean Neurological Association 1994;12(3):534-541
Therapeutic irradiation may produce a variety of adverse side effects on the central and the peripheral nervous systems. These adverse effects are divided into two main groups; transient and permanent. Four major clinical syndromes have been described in relation to permanent radiation injury of the nervous system: encephalopathy, cranial neuropathy, myelopathy, and peripheral neuropathy. Among them, delayed encephalopathy represents the major hazard in CNS irradiation. The characteristic MR imaging pattern of radiation induced delayed necrotizing leukoencephalopathy is symmetric, high-signal foci on T2WI in the periventricular white matter. We report a case of suspected post-irradiation leukoencephalopathy showed progressive mental change, quadriparesis, and urinary incontinence with characteristic MR findings who had taken therapeutic irradiation 12 months ago.
Cranial Nerve Diseases
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Leukoencephalopathies*
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Magnetic Resonance Imaging
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Nervous System
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Peripheral Nervous System
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Peripheral Nervous System Diseases
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Quadriplegia
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Radiation Injuries
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Spinal Cord Diseases
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Urinary Incontinence
10.Study of pH and gas analysis of umbilical arterial blood and apgar score as indicators of newborn health.
Dae Hyun CHO ; Mi Na LEE ; Min Whan KOH ; Tae Hyung LEE ; Sung Ho LEE
Yeungnam University Journal of Medicine 1991;8(1):98-106
Apgar score is most widely used evaluating indicator of newborn health, but it is very subjective. Umbilical cord blood gas analysis is more objective and effective than Apgar score in evaluation of newborn status. Cord blood gas was changed slightly by processing of time after fetal birth. This study was undertaken to observe objectiveness and effectiveness of umbilical arterial blood gas analysis and effects of time interval of cord clamping to newborn health with 122 pregnant women and their babies. We observed following results: 1. There were poor correlation between Apgar score and umbilical cord arterial blood analysis in evaluating of newborn health (P>0.05). 2. There was no clinical significance of Apgar score or umbilical arterial blood gas analysis as single indicator in evaluating of newborn health (P>0.05). 3. Gas analysis and pH of umbilical arterial blood was more helpful in evaluating of newborn health than Apgar score. 4. There were no significant effects of time interval of umbilical cord clamping to newborn health. 5. If there were no indications of early umbilical cord clamping, cord blood sampling at immediately after birth without cord clamping was more effective to evaluate newborn status.
Apgar Score*
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Blood Gas Analysis
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Constriction
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Cordocentesis
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Female
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Fetal Blood
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Humans
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Hydrogen-Ion Concentration*
;
Infant Health*
;
Infant, Newborn*
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Parturition
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Pregnant Women
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Umbilical Cord