The main methods to treat locally advanced non-small cell lung cancer are radiotherapy and chemotherapy. The combination of radiotherapy and chemotherapy includes sequential chemoradiotherapy and concurrent chemoradiotherapy. The effectiveness of concurrent chemoradiotherapy is superior to that of sequential chemoradiotherapy, but the toxicity of concurrent chemoradiotherapy increases as well. Continuing to explore new ways which can improve the effectiveness and reduce the toxicity is the current and future direction. [Key words] Carcinoma, non-small cell lung; Radiotherapy; Drug therapy

Objective To observe the effect of meridian-thumbing therapy on flexion deformity on knees of children with cerebral palsy(CP).Methods The therapy of thumbing the points from Chengfu to Chengshan of the meridian of Foot Taiyang Bladder was used for 40 CP children with flexion deformity on knees.Results After three months treatment,the positive flexion of knee joint in 40 children improved significantly than before(P<0.001).Conclusion The therapy of meridian-thumbing has obvious effect on flexion deformity on knees of CP children.

Objective To explore the clinical efficacy of Baofukang suppository and policresulen in the treat-ment of cervical erosion,and to observe and analyze the safety,thus to provide the basis for clinical treatment.Methods 268 patients with cervical erosion were selected,they were randomly divided into the control group and the observation group,134 cases in each group.The control group was treated with Baofukang suppository on the basis of conventional treatment.The observation group received Baofukang suppository and policresulen treatment.To assess the treatment effect of the two groups,and the wound healing time,improvement of the symptoms or signs and the vaginal adverse reactions were observed.Results The total effective rate of the observation group was 88.81% (119 /134),which was higher than that of the control group 79.85% (107 /134),the difference was statistically significant (χ2 =9.87, P <0.05).The wound healing time of the observation group was (23.31 ±1.78)d,which was shorter than that of the control group (27.58 ±1.96)d,the difference was statistically significant (t =11.20,P <0.05).The incidence rates of lumbosacral pain,leucorrhea and purulent secretions of the observation group after treatment were 9.70%(13 /134),5.94% (8 /134)and 3.73% (13 /134),which were lower than those in the control group after treatment [14.93%(20 /134),12.69% (17 /134)and 11.94% (16 /134)],and after treatment two groups were lower than those before treatment,there were statistically significant differences (χ2 =9.96,9.81,10.12,all P <0.05).After treatment,the contact bleeding of the observation group and the control group were 0.00% (0 /134)and 1.49%(2 /134),which were lower than those before treatment,the differences were statistically significant (χ2 =11.30,10.06, all P <0.05).The incidence rate of vagina adverse reaction of the observation groups was 17.16% (23 /134),that of the control group was 17.91% (24 /134),there was no statistically significant difference (P >0.05).Conclusion Baofukang suppository combined with policresulen has better clinical curative effect in the treatment of cervical ero-sion,which can shorten the wound healing time,reduce symptoms or signs of patients,and has high security.

The incidence of Crohn disease has gradually increased in recent years. The diagnosis and treatment of Crohn disease has gained more and more attention from clinicians. This article is to propose solutions to problems in the diagnosis and treatment of Crohn disease, based on evidence from clinical trials, including the diagnosis, differential diagnosis, management of steroid-refractory disease and anal fistula, and timing of surgery.
Crohn Disease ; diagnosis ; therapy ; Humans

Objective To investigate the effects of preconditioning with emulsified isoflurane(eISO)on inflammatory response to myocardial ischemia-reperfusion(I/R)injury in rats.Methods Forty SD rats of both sexes weighing 250-280 g were randomly allocated into 4 groups(n =10 each):groupⅠ sham operation(S);group Ⅱ myocardial I/R + normal saline(NS); group Ⅲ I/R + eISO and group Ⅳ I/R + 30％ intralipid(Ⅱ.)(vehicle for eISO).Myocardial ischemia was induced by occlusion of anterior descending branch of left coronary artery for 30 min followed by 180 min reperfusion.NS,30％ intralipid and elSO 2 ml/kg were infused iv over 30 min at 30 min before myocardial ischemia in groups Ⅱ,Ⅲ and Ⅳ respectively.The animals were killed at the end of 180 min repeffusion.Their hearts were removed for determination of infarct size and myocardial NF-κB p65 and ICAM-1 expression(by immuno-histochemistry)and plasma concentration of TNF-t(by radioimmunoassay).Results Myocardial I/R induced myocardial infarct and significantly increased plasina TNF-a concentration and myocardial ICAM-1 and NF-κB p65 expression in gro up Ⅱ,Ⅲ and Ⅳ as compared with'sham operation group (Ⅰ).Plasma TNF-a concentration and myocardial ICAM-1 and NF-kB p65 expression were significantly lower in group Ⅲ(eISO)than in group Ⅱ and Ⅳ.Conclusion Down-regulation of myocardial NF-kB and ICAM-1 expression and inhihition of inflammatoy response are involved in the mechanism by which preconditioning with iv elso protects against myocardial I/R injury.

OBJECTIVE To investigate Mycoplasma pneumoniae load index(MPLI)usefulness in the diagnosis of Mycoplasma pneumoniae(MP) infection in children.METHODS 110 throat swabs were collected with paired sera from the department of pediatry in our hospital from March to July 2008.The former fluorescence quantitative(FQ)-PCR assay was used to analyze throat swabs,microparticle agglutination assay(MAG) and MP-IgM assay for the sera.MP-IgM positive once or twice was used as a gold standard for MP infection,on which sensitivity(SEN),specificity(SPE),positive predictive value(+PV),negative predictive value(-PV) and ROC were calculated.RESULTS According to the gold standard,the values of SEN,SPE,+PV,-PV were 73.1-100.0%for a single MP-IgM,26.9-94.0% for a single MAG,46.2-94.0% for double MAG,26.9-95.2% for FQ-PCR alone and 26.9-98.8% for MPLI,respectively.CONCLUSIONS MAG shows limit in its clinical usage for the detection of MP antibodies.MPLI can diagnose acute MP infection earlier than MP-IgM.

On-body communication channels are a physical basis for the establishment of an effective and reliable wireless link between on-body nodes in wireless body area networks (WBANs).Due to normally strict limitations in transmit power and power consumptions of on-body nodes as well as the human-centered characteristics of WBANs,on-body channels are prone to be affected by the electromagnetic properties of human tissues,human movements,application environments and transceiver antennas,which increase greatly the complexity of the research on channel models.The paper discusses the developments,mathematical expressions and application characteristics of five types of on-body channel models,such as the simple path loss model,the hybrid path loss model,the small-scale fading model,the scenario-based model and the ultra-wideband model,and reviews the current progress on the modeling on-body channels.

Coagulopathy after traumatic brain injury is a coagulation dysfunction caused by brain tissue injury, which is characterized by over activations of coagulation, fibrinolysis and anticoagulation. It is the result of the interaction of multiple factors and multiple links with complicated pathophysiology. This study reivewed the clinical features and evidence-based evidences of coagulopathy after traumatic brain injury in order to summarize and discuss the latest progress in the diagnosis and treatment of coagulopathy after traumatic brain injury.

It is a request of social development for medical service to provide patients with high-quality and humanistic medical care.The medical science reform should be strengthened in order to disassociate medical care and medicine marketing.Medical service reform is to be furthered and medical curriculum be properly set up.The medical specialities,public subjects and humanistic care curricula should be compatible with each other,in order to coordinate with the development of modern medical skills and the cultivation of humanistic spirit,and cultivate medical talents with both exquisite medical skills and noble medical professionalism.

Alteration of intracellular free calcium during hypoxia was studied in cul-tured porcine pulmonary arterial endothelial cells. Intracellular free calcium was measuredwith the fluorescent prob, Fura-2/AM. It was found that hypoxia induced by bubbling N_2 to cells suspension increased intracellular free calcium of endothelial cells by 81?21%(n=8, P