1.Efficacy of the Measurement of 25-Hydroxyvitamin D2 and D3 Levels by Using PerkinElmer Liquid Chromatography-Tandem Mass Spectrometry Vitamin D Kit Compared With DiaSorin Radioimmunoassay Kit and Elecsys Vitamin D Total Assay.
Ho Seok KWAK ; Hee Jung CHUNG ; Dong Hee CHO ; Mi Hyun PARK ; Eun Suk KU ; Eun Jung PARK ; Han Jin OH
Annals of Laboratory Medicine 2015;35(2):263-265
No abstract available.
25-Hydroxyvitamin D 2/*blood
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Cholecalciferol/*blood
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Chromatography, High Pressure Liquid
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Humans
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*Radioimmunoassay
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Reagent Kits, Diagnostic
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*Tandem Mass Spectrometry
2.Interaction of Vitamin D and Smoking on Inflammatory Markers in the Urban Elderly.
Hyemi LEE ; Kyoung Nam KIM ; Youn Hee LIM ; Yun Chul HONG
Journal of Preventive Medicine and Public Health 2015;48(5):249-256
OBJECTIVES: Epidemiological studies have reported that vitamin D deficiency is associated with inflammatory disease. Smoking is a well-known risk factor for inflammation. However, few studies have investigated the interactive effect of vitamin D deficiency and smoking on inflammation. This study aims to investigate the interaction of vitamin D and smoking with inflammatory markers in the urban elderly. METHODS: We used data from the Korean Elderly Environmental Panel Study, which began in August 2008 and ended in August 2010, and included 560 Koreans > or =60 years old living in Seoul. Data was collected via questionnaires that included items about smoking status at the first visit. Vitamin D levels, high-sensitivity C-reactive protein (hs-CRP), and white blood cell (WBC) counts were repeatedly measured up to three times. RESULTS: The association of vitamin D and hs-CRP was significant after adjusting for known confounders (beta=-0.080, p=0.041). After separate analysis by smoking status, the association of vitamin D deficiency and hs-CRP in smokers was stronger than that in nonsmokers (smokers: beta=-0.375, p=0.013; non-smokers: beta=-0.060, p=0.150). Smoking status was an effect modifier that changed the association between vitamin D deficiency and hs-CRP (interaction estimate: beta=-0.254, p=0.032). Vitamin D was not significantly associated with WBC count (beta=0.003, p=0.805). CONCLUSIONS: Vitamin D deficiency was associated with hs-CRP in the urban elderly. Smoking status was an effect modifier of this association. Vitamin D deficiency was not significantly associated with WBC count.
25-Hydroxyvitamin D 2/blood
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Aged
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Biomarkers/blood
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Body Mass Index
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C-Reactive Protein/analysis
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Female
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Humans
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Inflammation
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Leukocyte Count
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Male
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Middle Aged
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*Smoking
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Urban Population
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Vitamin D/*blood
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Vitamin D Deficiency/diagnosis