Condensing 2-amino-4-methyl-5-carbe thoxythiazole obtained from the cyclization process between thioure and ethylacetoacetate and oidine with some acylating agents to yield 9 new compounds of thiazole. All of them were screened for their invitro antibacterial and antifungal activities with respect to clotrimazol and cloramphenicol. The results showed that [2-(3,5-substuted salicylamido)-4-methyl-5-car-bethoxythiazole] compounds are active against gram-positive bacteria.
2-aminothiazole ; Analogs & derivatives