Objective To know the TCM discipline development situation through analysis on TCM articles based on Chinese Science Citation Database (CSCD) in recent years. Methods Articles about TCM in CSCD from January 2010 to December 2015 were searched by computers. The CSCD literature analysis system was used to conduct metrological analysis from the aspects of publishing time, source journals, cited information, authors, publishing organizations, research themes, and fund support. Results The number of articles published on CSCD was increasing year by year from January 2010 to December 2015. 85.09% of articles focused on the field of general medicine. There were more than 100 CSCD journals included in TCM professional articles. 17 journals published more than 100 TCM professional articles. WANG Yong-yan academician was the author who published the most articles (121 papers). Academic output H index of six authors was more than 5. 31.52% articles in CSCD were cited. Natural Science Foundation of China (including general and youth projects) funded the highest number of articles (12.2%), reaching 1716 articles. Conclusion Analysis on articles from CSCD can outline the development situation of TCM discipline in China. In recent years, the number of TCM articles is increasing; subject integration is good; high-level teams are forming gradually; TCM discipline is developing fast. However, the citation frequency is low; scholar H index is not high; the overall level remains to be improved.

Objective To set up a method for determination of the trace amounts of aluminium(Ⅲ) in water samples. Methods Second derivative polarogaphy was used. Results In a solution of acetate buffer(HOAc-NH4OH, pH=5.8), Al(Ⅲ)reacted with Berllon Ⅲ to form a complex and a sensitive polarogaphic adsorptive wave appeared at -0.54 V(vs.SCE). By using the 2nd derivative polarogaphy measyrement, the wave height had a linear relationship with the concentration of Al(Ⅲ)in the range of 0.005-0.300 ?g/ml. The limit of detection was 3.0 ng/ml. RSDs were 5.4%-9.1%. Recovery rates were 92.7%-108.0%. Conclusion The present method is sensitive, accurate with high selectivity and can be applied to the determination of the trace amounts of Aluminium(Ⅲ) in water sample with satisfactory results.

Oxidative stress phys a very important role in the cerebral ischemia-reperfusion injury.The role of NADPH oxidases (NOX) in oxidative stress after ischemic stroke has been paid more attention and may become a new therapeutic target.This article sums up the major research progress between NOX and cerebral ischemia-reperfusion injury,discusses the characteristics of various isozymes and their relationship with stroke,further investigates the pathogenesis of stroke from the perspective of NOX,and provides a new idea for the prevention and treatment of ischemic stroke.

Mesenchymal stem cells (MSCs) play a neuroproteetive effect via a variety of mechanisms.They provide a new idea for the treatment of cerebral ischemia.However,the inadequate sources have significantly limited the possible clinical applications.Carbon nanotubes (CNTs),a new nanomaterials,can not only promote the adhesion,proliferation and differentiation of MSCs in vitro,but also as the cell carriers they can provide good microenvironmental guarantee for the survival of MSCs through the regulation of secretion of cytokines and neurotrophic factors,as well as regulation of biological characteristics of neurons,glial cells,and macrophages after their cell transplantation,provide a good microenvironment guarantee for the survival of MSCs,and promote the effect of MSCs on the therapeutic effect of cerebral ischemia.

Objective:To evaluate the methods of nano-dispersion systems and the stability of samples in medical devices.Methods: By analyzing the cause of agglomeration and comparing kinds of methods to orient the elements of nano-dispersion Systems and the evaluation means. Results: To obtain the repetitive results, the foundation methods of nano-dispersion systems should be recorded in detail and all the following tests should be based on it.Conclusion: The constitution and evaluation of a dispersion system in obtaining representative and reproducible results in biological evaluation is very important and should be studied case by case.

Membrane-associated guanylate kinases (MAGUKs) is a class of postsynaptic density proteins (PSDs) in the postsynaptic dense of the postsynaptic membrane,including PSD-95,SAP-102,PSD-93,and SAP-97.MAGUK family members contain several protein binding sites,and these special binding sites are responsible for mediating a variety of signal transduction.MAGUKs participate in the occurrence and development mechanisms in central nervous system diseases,and has become a topic of general interest of neuroscience.This article briefly reviews the roles of MAGUKs in ischemic brain injury.

Apolipoprotein E (ApoE) has gene polymorphism (ε2,ε3,and ε4).It has been confirmed that ApoE structural and functional abnormlities are closely associated with the hyperlipidemia,formation of atherosclerosis,and its severity,while both hyperlipidemia and atherosclerosis are the risk factors for ischemic stroke.In recent years,although the relationship between the ApoE gene polymorphism and ischemic stroke has been extensively studied,the conclusions are not consistent.This article reviews the correlation studies between the ApoE gene polymorphism and ischernic stroke.

Astrocytes are the most abundant neuronal cells in the central nervous system.It plays an important physiological role.In the process of cerebral ischemia,astrocyte activation is one of the major changes in the central nervous system.The activated astrocytes can play a neuroprotective role through the mechanisms such as maintaining ionic balance,regulating energy metabolism,removing excitatory amino acids,against oxidative stress,and secreting neuroprotective substances.However,astrocyte activation after cerebral ischemia also has its disadvantage.This article reviews the neuroprotective and damage roles of astrocyte activation during cerebral ischemia.It also investigates its regulatory mechanisms in order to provide new ideas for the treatment of ischemic stroke.

The incidence of poststroke dementia is high and the burden of disease is heavy. It is very important to prevent or delay its occurrence and progression. In recent years, the lifestyle adjustments, such as the intervention for vascular risk factors, adhering to the diet management, and functional exercise have been confirmed to prevent poststroke dementia to a certaln extent. Acetylcholinesterase inhibitor and glutamate receptor antagonist, etc. play an important role in delaying the progression of poststroke dementia and vascular cognitive impalrment. This article reviews the latest progress in research on the prevention and treatment of poststroke dementia.

Immuno-inflammation is one of the main pathophysiological mechanisms of ischemic brain injury,of which chemokines and its receptors widely participate in the occurrence and development processes of ischemic brain injury.Interleukin-8 (IL-8) and its receptors participate in the activation and chemotaxis of neutrophils into brain tissue,and may further aggravate cerebral ischemia-reperfusion injury.At present,therapeutic drugs for IL-8 are mainly CXC chemokine receptor 2 antagonists,including narrow and broad-spectrum chemokine antagonists.This article reviews the advances in research on the pathological mechanism and targeting treatment of IL-8 in ischemic brain injury.