Objective To analyze the effect of Fuke Xiaoyan prescription combined with nifuratel and nysfungin in senile mycotic vaginitis. Methods 100 patients with senile mycotic vaginitis were randomly divided into the observation group and the control group ,50 cases in each group.The control group were treated with nifuratil nystatin alone.The observation group were treated with Fuke Xiaoyan prescription.The inflammatory factors of tumor necrosis factor (TNF-α), C-reactive protein (CRP), interleukin-6 (IL-6) and interleukin-8 (IL-8) and oxidative stress products of SOD, nitric oxide (NO), malondialdehyde (MDA) and endothelin-1 (ET-1) were determined before and after treatment in the two groups.Results The effective rates of the treatment group and the control group were 96.0% and 80.0% respectively.The clinical efficacy of the observation group was higher than that of the control group ( P<0.05 ) .The difference of the inflammatory factors between the two groups was statistically significant ( P<0.05 ) .The levels of SOD and NO in the two groups were significantly higher than those in the control group (P<0.05), but the levels of the inflammatory factors in the observation group were significantly lower than those in the control group ( P<0.05 ) .The levels of MDA and ET-1 in observation group were significantly lower than those in control group (P<0.05).Conclusion Fuke Xiaoyan prescription combined with nifuratil and nystatin has a good effect in the treatment of senile mycotic vaginitis.It can effectively relieve the inflammatory reaction and reduce the level of oxidative stress products , thus improving the patients'life quality.

Polymyositis (PM) and dermatomyositis (DM) are inflammatory myopathies and slowly advanced of unknown etiology that affect the skeletal muscles.With the advancement of the constant research on the disease and use of new technology,people have a penetrating realization about the pathogenesis. The disease is thought to be associated with autoimmune as well as nonimmune mechanism. By now, there is no overall summary on the newest advancement of the pathogenesis.We summarized the progress on the pathogenesis of the disease in order to make it more clear to physicians.

ObjectiveFor finding out the early stage growth circumstance of high risk neonate, we studied continuously recently years through regular checkups and early stage education directing. Methods1040 high risk neonates were followed up and checked once 1-3 months.ResultsThey are 2 cases cerebral palsy and 15 cases sports growth backward with posture abnormal. Through early stage restored training and treating, all of them are improved on the sports growth and posture. ConclusionsEarly intervention, regular checkups and early stage education, is a useful way for high risk neonate.

Adult ; Humans ; Male ; Middle Aged ; Pneumoconiosis ; diagnostic imaging ; Radiography, Thoracic ; methods ; Tomography, Spiral Computed

ObjectiveTo investigate prognostic factors in acute exacerbation of COPD (AECOPD).Methods352 AECOPD patients were investigated.26 possible variables were analyzed.Multivariate Logistic and Cox proportional-hazards regression analysis were used.ResultsAccording to multivariate Logistic regression,it showed seven factors were statistically significant for short term prognosis ( P ＜0.05 ),including PaO2 ( OR =0.082),CKMB ( OR =4.967 ),mechanical ventilation ( OR =6.903 ),albumin ( OR =0.221 ),FEV1％ ( OR =0.255 ),charlson index ( OR =8.406 ) and hospital day ( OR =0.075).According to multivariate Cox regression,it showed seven factors were statistically significant for long term survival ( P ＜ 0.05 ) including acute exacerbation frequency( HR =1.611 ),charlson index( HR =4.319),SaO2 ( HR =0.224 ),troponin Ⅰ ( HR =3.824 ),albumin ( HR =0.569 ),hospital day ( HR =0.456) and FEV1％ (HR =0.494).Acute exacerbation frequency was correlated with dyspnea scale( rs =0.508,P ＜ 0.01 ).ConclusionsPaO2,albumin,FEV1％,CKMB and charlson index were related with short term prognosis.SaO2,albumin,FEV1 ％,troponin Ⅰ,charlson index and acute exacerbation frequency were related with long term survival.Higher acute exacerbation frequency contributed to more severe breathing difficulties and worse quality of life.

Objective To investigate clinical effect of Danhong injection combined with edaravone in patients with idiopathic pulmonary fibrosis (IPF) and influence on TNF-αand TGF-β1 in serum.Methods 67 patients were randomly divided into Treatment Group (n=35) and Control Group (n=32) in Xuanwu hospital of Nanjing from March 2011 to December 2014.All the patients were treated by comprehensive conventional treatment, and then control group was treated by edaravone, treatment group were treated by Danhong injection on the basis of control group.The clinical efficiency, PaO2 , carbon monoxide diffusing capacity (Dlco) and the levels of inflammatory factors between two groups were compared.Results After treatment, the clinical total effective rate(97.14%) of treatment group was statistically higher than that of control group (75.00%, Z=-2.035,P=0.042).After treatment, partial pressure of oxygen(PaO2) and Dlco in treatment group were increased significantly(all P<0.05);and it was statistically higher then control group (all P<0.05).TNF-αand TGF-β1 in treatment group were decreased significantly (all P<0.05);and it was also statistically higher then control group (all P<0.05).Conclusion Danhong injection combined with edaravone is effective in treatment of IPF, which can significantly improve the pulmonary function and levels of inflammatory factors.

Objective To explore the puberty and height development in childern with congenital adrenal hyperplasia(CAH) due to 21-hydroxylase deficiency(21-OHD) with the simple virilizing(SV) form.Methods Patients of SV 21-OHD,diagnosed and treated in Tianjin Children's Hospital from Jan.1970 to Jan.2008,were treated with cortisone acetate or hydrocortisone after diagnosed,and blood investigations were performed as part of monitoring,and dosages were adjusted accordingly to obtain normal growth velocity and slow bone age(BA) development.Gonadotropin-releasing hormone agonist(Gn-RHa) was given after the appearance of central precocious puberty(CPP).Forty-one patients(18 females,23 males) had achieved final height before Dec.31st 2008,and their puberty and height development were analyzed in this longitudinal study by contrast the ages and statures of obtaining final height(FH),chronological age(CA) and BA of G2/B2 stage,duration from G2/B2 stage to obtain FH and stature development of different gender during this period and the influences of compliancy on the ages and statures of obtaining FH were contrasted.Results With regarding to the age of testicular volume ≥4 mL,78.26% boys were before 9 years old.As far as the age of breast development was concerned,38.89% girls were before 8 year old and 66.67% menarche occurred before 10 year old.The differences between the duration and stature development of the period from the state of G2/B2 to skeletal maturation of different gender were significant (Pa

Objective To analyze rate of and reasons for not undertaking insulin pump therapy in children with type 1 diabetes(T1DM) and explore potential countermeasures.Methods Two hundred and seventy-eight persons of T1DM,diagnosed in Tianjin Children′s Hospital from Jan.2000 to Dec.2008,were assigned to fill in a questionnaire on T1DM and insulin pump therapy.Reasons for different compliances were analyzed and strategies were explored.Results Eighty-five point twenty-five percent of the children(237 persons) undertook the therapy and 14.75%(41 persons) refused.In the group of younger than 3 years,58.33%(21 persons)accepted the therapy,while in the group of older than 3 years,89.26%(216 persons) undertook it,consequently there was statistically significant difference(?2=23.83,P

Objective:To investigate the clinical significance of dynamic analysis of plasma brain natriuretic peptide in patients with dilated cardiomyopathy with chronic heart failure.Methods:Ninety patients with dilated cardiomyopathy with chronic heart failure admitted into our hospital firom March 2012 to March 2016 were divided into group A (20 cases),group B (38 cases),and group C (32 cases) according to the NYHA grading.The plasma BNP levels and LVEF,LA,LVEDD,and LVESD in the three groups were detected and compared.The correlation of plasma BNP and cardiac function and ultrasonic cardiogram indexes were analyzed.And the capability of plasma BNP and LVEF in diagnosis of patients were analyzed and compared.Results:The plasma BNP level in group C was markedly higher than that of group A and group B (P＜0.05),and that in group B was much higher than that of group A (P＜0.05).And LA in group C was significantly higher than that of group A (P＜0.05),while differences in LVEF,LVEDD,and LVESD were not obvious (P＞0.05).The plasma BNP was positively correlated to NYHA grading,but had no significant correlation with the LVEF,LVEDD,LVESD,and LA (P＞0.05).Based on results of receiver operating characteristic curve analysis,plasma BNP =523.5 pg/mL was the threshold value for identification of patients with NYHA Ⅲ and Ⅳ (AUC=0.901,P＜0.001),while LVEF had not the capability (AUC=0.392,P=0.276).Conclusion:Detection of plasma BNP level had important clinical significance on diagnosis,screening and cardiac functional grading of patients with dilated cardiomyopathy with chronic heart failure.