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Humans ; Publishing

Animals ; Antibodies, Monoclonal ; Carcinoma, Non-Small-Cell Lung ; drug therapy ; Crown Ethers ; therapeutic use ; Drug Resistance, Neoplasm ; Erlotinib Hydrochloride ; Humans ; Immunoglobulins, Intravenous ; therapeutic use ; Lung Neoplasms ; drug therapy ; Molecular Targeted Therapy ; Mutation ; Precision Medicine ; Protein Kinase Inhibitors ; therapeutic use ; Pyrazoles ; therapeutic use ; Pyridines ; therapeutic use ; Quality Control ; Quinazolines ; therapeutic use ; Receptor, Epidermal Growth Factor ; antagonists & inhibitors ; genetics

OBJECTIVE:To establish a simple method for drug bioequivalence test based on Excel function.METHODS:The statistical tests including ANOVA,two one-side test and 90% confidence interval were carried out using Excel statistical function.RESULTS:Drug bioequivalence test can be performed based on Excel,with results in line with those stated in Biopharmaceutical and Pharmacokinetic.Moreover,due to Excel's repeated calculation function,for retest,three kinds of test results were available rapidly only by replacing the data with others remained for calculation.CONCLUSION:Excel function can be used to calculate drug bioequivalence.

Objective To study the advances in research of breast cancer during pregnancy. Methods The literatures in recent years were reviewed. Results A lot of evidences suggested that the diagnosis may be delayed easily. The diagnosis was primarily made by needle aspiration cytology and biopsy. The treatment of pregnant breast cancer was not different from ordinary breast cancer, however the factor of foetus should be taken into account. Termination of pregnancy did not improve survival.Conclusion Pregnant breast cancer is mostly at later stage at the time of diagnosis and has poorer prognosis than ordinary breast cancer. The patients with breast cancer during pregnancy usually have an equivalent survival rate when compared with age and stage-matched ordinary group. Future pregnancy may be allowed after two years of treatment in patients with early breast cancer.

Thyroid fine needle aspiration biopsy, ultrasonographically guided thyroid fine needle puncture and the common cytologic pathological characterstics of various thyroid diseases are reviewed, and the clinical application is discussed.

The article reviews primary, secondary and tertiary prevention strategy of thyroid diseases and its possible effect.

It is critical to assess the development and injury of brain function in premature infants in early stage.Currently,brain development and brain injury are evaluated by many ways and mainly by kinds of imaging and behavioral neurological assessment.The integrated application of these examination methods have been explored for years.The combination of resting-state functional magnetic resonance imaging and electroencephalography has prominent advantages,because they do not need to perform specific tasks,and they are noninvasive and non-toxic for preterm infants.Based on the support vetor machine learning of artificial intelligence technology,the typical characteristics of 2 multimodal data can be integrated and a multimodal assessment system which automatically monitor and predict premature infants' brain function development and injury can be established.

"Seven kinds of prescriptions" and "Ten formulas of materia medica" were important classifications of prescription. According to textual research, the title of"Seven kinds of prescriptions" appeared fi rst in XU Shu-wei’s Shang han jiu shi lun (Ninety Essays on Cold Pathogenic Diseases), which was applied in medical education in the Song Dynasty. The title of "Ten formulas of materia medica" was beginning from CHEN Cang-qi’s ten kinds of "general drugs", and its concept was expanded from "kind" of drugs into "prescription" in Sheng ji jing (Classic of Holy Universal Relief) of the Song Dynasty. These two classif ications had great influence on classif ication of prescription based on functions in later time. The development of "Seven kinds of prescriptions" and "Ten formulas of materia medica" in the Song Dynasty was discussed, and the reasons was analyzed in this paper.

Objective To investigate the effects of micronutrients selenium(Se), vitamin E(VE), vitamin C(VC) and magnesium(Mg) on levels of TXA 2, PGI 2 in plasma of rats with hyperlipidemia induced by high fat and high cholesterol diet. Methods Sixty Wistar juvenile rats were randomly divided into five groups. Each group was fed with normal diet, high fat and high cholesterol diet (HFD), HFD+Se+VE+VC, HFD+Mg, and HFD+Se+VE+VC+Mg, respectively. After eight weeks, the rats were sacrificed for the detection of levels of lipid, TXA 2 and PGI 2 in the blood. Result Micronutrient complex (Se, VE, VC, and Mg) can significantly inhibit the increase of blood triglycerol, total cholesterol, LDL C and TXA 2 induced by HFD and can significantly increase HDL C. Conclusion Micronutrient complex (Se, VE, VC, and Mg) has the lipid lowering effect and can decrease TXA 2/PGI 2 ratio, which is beneficial to the prevention of atherosclerosis.

Thirty-four cases of hyperlipidemia were treated by embedding No.0 catgut in 2cm length into bilateral Zusanli (ST 36) and Jiaji (Ex-B 2) of the tenth thoracic vertebra and were compared with 30 cases treated by oral administration of Pravastatin. After two months, the acupoint catgut-embedding method had the same effect as Pravastatin in reducing total serum cholesterol, and had a better effect in reducing triglyceride.