Objective To investigate the quality of life (QOL) of patients with frequent premature ventricular contractions (PVCs) and the effects of radiofrequency catheter ablation (RFCA) on them.Methods 120 patients with frequent PVCs,100 cases with frequent APCs and 60 healthy persons were assessed by 36-Health survey questionnaire (SF-36) originally.Three months later,the QOL of 48 cases received RFCA and 72 cases with drug therapy were evaluated again by SF-36.Meanwhile,decrease of PVCs were also calculated between these two groups.Results The scores of physiological function and mental health in patients with PVCs were lower than that of cases with APCs,while the score of bodily pain in patients with PVCs was higher (P value:0.0002-0.0380).In addition,the quality of life in patients with frequent PVCs were worse than healthy control(P value:0.0001-0.0915).Three months later,PVCs in 48 cases with frequent PVCs received RFCA were much fewer than that of 72 cases with drug therapy (t=18.8682,P＜0.01),and the quality of life in the former was much better than the latter (F=15.329-39.274,P＜0.01).Conclusion Frequent PVCs can deteriorate the patients' quality of life.RFCA can control or eliminate PVCs in these patients and markedly improve the quality of life of them.

Pain is a common symptom among populations with life-limiting illnesses. Like all clinicians, family physicians involved in the care of these patients should acquire the skills and knowledge required to provide good pain control in order for the patients and their caregivers to achieve optimal quality of life. This paper is a review and presentation of the definition, classification, assessment and management of pain at the end of life based on available guidelines and evidence.

Humans ; Maxillofacial Injuries ; diagnosis ; surgery ; Wounds, Gunshot ; diagnosis ; surgery

Forensic Ballistics ; Humans ; Maxillofacial Injuries ; surgery ; Wounds, Gunshot ; surgery

Bone Transplantation ; Humans ; Mandible ; transplantation ; Transplantation, Homologous

Objective To explore the effects of wound healing and histological changes by utilizing ultrapulse CO2 fractional laser for the treatment of superficial scar in dermal-epidermal junction (DEJ) in rabbit ears.Methods We adopted traditional iodophor treatment and moist exposed burn ointment treatment repairing the wound and utilizing ultra pulse CO2 fractional laser for the treatment of rabbit ears superficial scar.The superficial scars in rabbit ear were induced with ultra pulse CO2 fractional laser.In 1,2,4,8 weeks tissue samples would be taken.Using electron microscopy we observed DEJ ultrastructure and light microscopy to observe the histological changes of the dermal papilla and PAS staining for epidermis basement membrane.Results The wound healing time of moist exposed burn ointment group was shorter than that of iodophor group (P＜0.05).The number of hemidesmosomes and anchoring fibers in the moist exposed burn ointment group on the 8th week was more than the 1th week,The number of hemidesmosomes and anchoring fibers in the iodophor group on 8th week was more than 1th week (P ＜0.05).The number of hemidesmosomes and anchoring fibers in the iodophor group was less than the moist exposed burn ointment group (P＜0.05).Conclusions U1trapulse CO2 fractional laser can cause ultra structural changes in scarring dermal-epidermal junction area,wet wound healing environment promotes the reconstruction of DEJ district organization,and rebuilding the function of the scar skin has the positive significance.

Objective To study the effects of propofol on cognitive function and expression of BDNF in the cerebral cortex after the traumatic brain injury (TBI).Methods Forty-eight SD rats treated with the Morris water maze were randomly divided into 3 groups with 16 rats in each group.Rats in the sham group were subjected to the operative procedure but prevented from traumatic brain injury.Rats in the control group and the propofol group were subjected to the traumatic brain injury named Feeney.After the operation,rats in the propofol group were injected propofol for 6 hours.The neurological functional status and the cognitive function of rats were assessed with NSS scores and Morris water maze tests on 3d and 14d post operation.RT-PCR and Westeron Blot were used to detect the expressional changes of BDNF in the injured cerebral cortex.Results Compared with the sham group,NSS scores and the latencies of escape among rats in the control group were increased and times of crossing platform were decreased at 3d and 14 d post operation (P ＜0.01),and the mRNA and protein levels of BDNF were decreased at 3d post operation (P ＜0.01).Compared with the control group,the mRNA and protein levels of BDNF in the propofol treated rats were increased at 3d and 14d post operation (P ＜0.01),NSS scores were lower at 14d (P ＜0.01),the latencies were shorter and the times were increased (P ＜0.01).Conclusion Propofol improves the the expression of BDNF in the injured cerebral cortex and facilitates the recovery of the neurological and cognitive function in rats with traumatic brain.

OBJECTIVE:To promote the normative management of clinical off-label drug use. METHODS:The degree of devi-ation from the drug instructions and the risk degree were comprehensively considered,and the off-label drug use were classified in-to three different situations for classifying approval and informed consent classifying;situation and effects after classifying were evaluated. RESULTS:The classifying included occasional or small amount off-label use on dosage and drugs solvent (the first), regular off-label use on route or administration(the second)and super-indications drug use with contraindications(the third). The approval was classified as follows as confirmed with signature by doctor,approved by medical department,approved by pharmaceu-tical committee and ethics committee accordingly;informed consent classifying were signing informed consent,informing and re-cording in medical record,informing orally. Off-label drug use approval process was officially initiated from Feb. 2014 to Jun. 2016 in our hospital,51 off-label drug use applications from 13 clinical departments were received,with 16 items belonging to the second situation,35 items belonging to the third. Finally 42 applications were approved and 9 were not. No relevant new/serious ad-verse drug reactions/ events occurred in process of the approved off-label drug use. And no off-label drug use not approved was found to continue to be used in our hospital. CONCLUSIONS:Classification management methods for off-label drug use in our hos-pital have shown high operability,improved the off-label drug use behavior of physicians.

Objective To study CT findings, diagnosis and differential diagnosis for prostate cancer. Methods 28 cases with prostate cancer confirmed by surgery and pathology, of them 4 cases were recurrence after operation. Results In 24 cases confirmed by surgery 21 (87.5%) were diagnosed by CT. Their CT appearances were : (1) Focus: in non enhanced scanning the prostate was enlarged unevenly in 18 cases. The density of the mass was slightly lower than the normal prostate in 17 cases, and equal to normal in 11 cases. Patchy calcification was seen in 2 cases moderate. In enhanced scanning, 22 cases showed nodular enhancement but slightly less than normal, 6 cases were equal to normal. (2) Metastastic lesions: 8 cases had local thickened bladder wall, 4 cases had enlarged seminal vesicle with unneven density, 2 cases with thickened anterior wall of rectum.And pelvis mass, enlarged lymph nodes, bony destruction of pelvis and pulmonary metastasses 1 case for each respectively. Conclusion (1) It is emphasized enhanced CT study should be a routine examination in the diagnosis of prostate cancer by CT; (2)CT can define the extent of the lesion and metastases thereby helpful to predict the prognosis and evaluate the effect of treatment.

By mechanical comparison study of ARRIF,Dick and AF ,their reliable basis for further clinical application was evaluated. Models of spinal fracture were made using fresh cadavers. According to the Latin squre experimental designing principle, the fracture specimens were fixed with ARRIF,Dick and AF separately. The shift and angle changes were observed under different loads,and the analysis of variance was performed to all the data with the SPSS software . The single spinal compression fracture model showed no significant shift and the mechanical features were similar when it was fixed by ARRIF,Dick and AF. The model of spinal compression fracture with three spinal damages showed significant differences among these three fixings when axial torsion load was given. ARRIF and AF were clearly superior to Dick. The histological observation of ARRIF recorded no significant changes in the bone trabecula around the nail pass and the structure kept normal. The mechanical feature of ARRIF was basically similar to that of AF and Dick. Our conclusion is that because of the characteristics of its designing, the anti-axial torsion ability of ARRIF is outstanding and it can be easily fixed in application, thus it holds certain value in clinical practice.