2.Chemotherapy treatment of hepatoblastoma in children
International Journal of Pediatrics 2015;42(5):553-555
Hepatoblastoma(HB) is the most common malignant hepatic tumor in the pediatric population,almost exclusively in infants and toddlers, which accounts for 50% ~ 60% of the liver tumors.Now, the comprehensive treatment program of HB in children includes surgery, chemotherapy, radiotherapy, and so on.Liver transplantation and autologous peripheral blood stem cell transplantation could also be applied to advanced or refractory hepatoblastoma in children.The high sensitivity of childhood hepatoblastoma to chemotherapeutic agents,makes chemotherapy as one of the main treatment modalities.This review mainly discusses chemotherapy treatment of HB in children.
3.Etfects of ATP on cerebral blood flow velocity and vascular responses during hyperventilation.
Chinese Journal of Anesthesiology 1994;0(04):-
The effects of ATP on cerebral blood flow velocity and vascular responses to hyperventilation using TCD in the middle cerebral artery were studied in 15 patients. Anesthesia was maintained by infusion of 1% procaine (1ml.kg-1/min) and inhalation of 1% enflurane-40%N2O-O2. Mean blood flow velocity in left middle cerebral artery was measured and cerebral vascular reactivity to hyperventilytion was assessed before and during the administration of ATP.The cerebral reactivity was expressed as the percentage change in mean blood flow velocity per unit change in PETCO2. During the administration of 1%ATP,a 34% reduction in MAP with mean blood flow velocity decreased significantly from 61.5 to 53.1cm/s (P
4.Effect and mechanism of kansui root on microcirculation of pancreatic tissues in rats with severe acute pancreatitis
Chinese Journal of General Surgery 1997;0(06):-
Objective To explore the effect and mechanism of kansui root on microcirculation of pancreatic tissues in severe acute pancreatitis(SAP) rats.Methods SD rats were randomly divided into sham group(S group),SAP group and kansui root therapy group(K group).40 rats in each group.Serum amylase,and thromboxame-B2(TXB_2),6-Keto-F_(1?)(6-Keto PGF_(1?))levels and expressions of cyclooxygenase-2(COX-2)mRNA and protein in pancreatic tissue,microscopy and election microscopy of pancreas,mortality within 72 hour after operation in each group were tested at 2h,6h,12h,and 24h after operation.Results (1)The TXB_2,6-keto PGF_(1?) levels and the ratio of TXB_2/6-Keto-PGF_(1?)(T/P) in SAP group were all(obviously) higher than those in S group(P
5.Inhibitory Action of Salidrose on Hepatic Fibrosis
China Pharmacy 2001;0(11):-
OBJECTIVE:To investigate the inhibitory action of salidrose on hepatic fibrosis of rats.METHODS:CCl 4 -induced hepatic fibrosis rat(n=55)model was built up,then were administrated low,median and high dose of salidrose positive control malotilate,and compared with normal group(n=10),the pathohistological changes were observed after6wk under light microscope and hepatic fibrosis degree was monitored before and after treatment by determining levels of ALT,AST,NO,HA and LN in serum and Hyp and MDA in liver tissue.RESULTS:Salidrose significantly reduced the elevated levels of ALT,AST,NO,HA,LN in serum and the exorbitant Hyp and MDA in liver tissue.Histopathologic examination also showed its significant amelioration effect on experimental liver fibrosis.CONCLUSION:Salidrose has inhibitory action on experimental liver fibrosis to some extent.
6.A comparative study for the caries activity between orthodontically treated and untreated group in adult orthodontic
Journal of Chongqing Medical University 2003;0(05):-
Objective:To detect the caries activity of orthodontical treated and untreated adult.Methods:The study population consisted of 30 adults whose age are over twenty,the control group includes 30 adults who did not accept any orthodontical treatment.The detective methods were enumeration of streptococcus mutans in saliva,ability of plaque to produce acid and salivary buffering capacity.Student's test was used to analyse the statistical difference.Results:The results showed that the number of S.mutans and lactobacillus on the untreated group are much lower than that of the orthodontical group;the salivary pH,salivary buffering capacity and ability of germ to produce acid are similar between orthodontical treated and untreated adult.Conclusion:This study suggests that the orthodontical treated adult are more sensitive to dental caries than untreated adult.
7.Observation of clinical effects of three kinds of desensitizer on dentin hypersensitivity
Journal of Chongqing Medical University 1986;0(03):-
Objective:To eveluate the clinical effects of treating dentine hypersensitivity with three kinds of desensitizer(Prime & Bond NT,GLUMA desensitizer and 75% sodium fluoride glycerin).Methods:324 teeth with dentin hypersensitivity were divided into three groups.Group A:Prime & Bond NT adhesive.Group B:GLUMA desensitizer.Group C:sodium fluoride.Results:Instant,effective rates in group A and group B were significantly higher than that in group C(P0.05).After three months,effective rates in group A was significantly higher than that in group B(P
8.Extraction of Schisandra Chinensis (Turcz) by supercritical carbon dioxide
Chinese Traditional Patent Medicine 1992;0(08):-
AIM:To study the extraction of Schisandra Chinensis (Turcz) using supercritical carbon dioxide as extracting ageat. METHODS: The study was carried out through orthogonal test design,the content of schizandrin from Schisandra Chinensis (Turcz) was selected by 3 influencing factors, extract temperature, extract pressure and separation temperature. RESULTS:The optimal condition for the extraction as A3B2C1 Schisandra Chinensis (Turcz) was extracted by supercritical carbon dioxide, extract pressure was 25MPa, extract temperature was 50?C, separation was 7 MPa, separate temperature was 60?C, extract time was 2.5h and runing amount of CO2 was 15kg?h -1. CONCLUSION:It is feasible that supercritical carbon dioxide is used in the preparation of Schisandra Chinensis (Turcz).
9.The epidemiological investigation of the caries and periodontal disease in elderly people of Chongqing
Journal of Chongqing Medical University 2007;0(07):-
Objective:To investigate the oral health status of elderly people in Chongqing,and research incidence of caries and periodontal diseases in elderly people,in order to supply enough information for constituting programme of oral health care for elderly people. Methods:Based on oral health survey methods set down by World Health Organization and second national oral health survey standards,proportional stratified randomized sampling was employed in 2005. The total 762 samples from three cities and three countries were examined. Results:The coronal caries rate was 75.95%;the mean number of coronal caries was 14.32;the root caries rate was 58.40%,and the mean number of root caries was 4.24. Gingival bleeding rate was 98.82%;periodontal pocket rate,96.06%,and periodontal attachment loss rate,41.77%. Conclusion:Caries prevalence rate is high and periodontal health status is poor. These results suggest that oral care service should be established to improve the oral health status of elderly people in Chongqing and prevent epidemic of oral diseases.
10.Effect of high zinc concentrations on contents of iron and zinc and expression of their regulating mRNA in Caco-2 cells
Academic Journal of Second Military Medical University 1982;0(01):-
Objective:To observe the effect of high zinc concentrations on contents of iron and zinc and expression of their regulating mRNA in Caco-2 cells.Methods: Caco-2 cells were used as model of human small intestinal enterocytes and were treated for 24 h with 4,50,100 and 200 ?mol/L of zinc.The zinc and iron contents were determined by atom absorption spectrophotography and the expression of DMT1,IREG1,ZnT1 and hZIP4 mRNA were determined by RT-PCR(the level of GAPDH was taken as internal control).Results: The zinc content in Caco-2 cells was increased 24 h after treatment with zinc,and reached the peak when exposed to 50 ?mol/L zinc.The iron content decreased with the increase of zinc concentration.Zinc supplement increased the expressions of DMT1,IREG1 and ZnT1 mRNA but decreased the expression of hZIP4 mRNA.Conclusion: It is suggested that zinc supplement can increase the contents of zinc but decrease the contents of iron in Caco-2 cells.There may be interactions between iron and zinc in the intestinal lumen.