1.Epidemiological Investigation of Prevalence of Yin and Yang Deficiency Syndrome on Different Nationalities in Xinjiang Autonomous Region
Yan WANG ; De JIANG ; Mingxin ZHOU
Journal of Traditional Chinese Medicine 1993;0(04):-
Objective To investigate the prevalence and distribution of Yin and Yang deficiency syndrome on different nationalities in different parts of Xinjiang in order to offer epidemiology evidence for the research on the cause of dryness syndrome in northwest China.Methods The questionnaire was designed according to the Chinese medicine theories and the sampling questionnaire investigation in five regions including Hotan Xinjiang and Leshan Sichuan and Shanghai was carried out.Then a computation differentiation of Yin and Yang deficiency syndrome was done for the statistical analysis.Results Totally 5544 questionnaires were accomplished.In the five regions except Urumqi,the incidence of Yin and Yang deficiency syndrome in Xinjiang was higher than that of Shanghai and Sichuan(P
4.Expression of Matrix Metalloproteinase-9/Tissue Inhibitor of Metalloproteinase-1 in Rats with Tubulointerstitial Fibrosis
yan, WANG ; de-an, ZHAO ; da-sheng, YANG
Journal of Applied Clinical Pediatrics 1992;0(05):-
Objective To observe the expression of matrix metalloproteinase-9(MMP-9)/tissue inhibitor of metalloproteinase-1(TIMP-1) in tubulointerstitial fibrosis(TIF) rats and explore the effects of MMP-9 and TIMP-1 in TIF.Methods Forty-eight male Sprague-Dawley(SD) rats were randomly divided into sham-operated group(n=24) and model group(n=24).Results Tubulointerstitial fibrosis model was established via unilateral ureteral obstruction(UUO). Histological changes were observed in tubulointerstitium injury under microscope and immunohistochemistry staining was performed to investigate both the expression of MMP-9 and TIMP-1 in TIF by semiquantitative score at d7, d14, d21 after experiment onset.The expressions of TIMP-1 in rats from sham-operated group were lower than those of mo-del group rats at d7, d14, d21 (Pa
9.Effects of alkaloids from coptidis rhizoma on blood lipid metabolism and low-denstity lipoprotein receptor mRNA in golden hamsters.
Hao WU ; Yan-Zhi WANG ; De-Zhen WANG ; Jie PANG ; Xiao-Li YE ; Xue-Gang LI
China Journal of Chinese Materia Medica 2014;39(11):2102-2105
To study the effects of alkaloids from Coptidis Rhizoma on low-density lipoprotein receptor (LDLR) mRNA expression and antihyperlipedemic levels. The LDLR mRNA expression were detected by real time fluorescence quantitative PCR, and the levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-c) and high-density lipoprotein cholesterol (HDL-c) in serum were measured at the first and last examination. The results show that, after the drug treatment, compared with the model group, each drug group showed a lipid-lowering effect. Especially, coptisine, palmatine, jatrorrhinze were significantly reduced TC, TG, LDL-c (P < 0.05, P < 0.01), and increased HDL-c (P < 0.01). In addition, they also increased mRNA expression of the LDLR in liver and HepG2 cells. The results showed that alkaloids from Coptidis Rhizoma can regulate lipid metabolism disorder, and coptisine have the best lipid-lowering effect.
Alkaloids
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administration & dosage
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Animals
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Cholesterol
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metabolism
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Cricetinae
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Drugs, Chinese Herbal
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administration & dosage
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Humans
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Hyperlipidemias
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drug therapy
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genetics
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metabolism
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Hypoglycemic Agents
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administration & dosage
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Lipid Metabolism
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drug effects
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Lipids
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blood
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Lipoproteins, LDL
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metabolism
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Mesocricetus
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Receptors, Lipoprotein
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genetics
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metabolism
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Triglycerides
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metabolism
10.Meta - analysis of clinical randomized controlled trials comparing ReZOOM with ReSTOR multifocal intraocular lenses in cataract surgery
De-Wang, SHAO ; Chun-Yan, YANG ; Wei, CHEN ; Hua, WANG ; Bing, LIU
International Eye Science 2014;(6):1030-1036
AIM: To systematic review the effectiveness of refractive multifocal intraocular lens ( MIOL ) ReZOOM vs diffractive MIOL ReSTOR in the treatment of cataract.
METHODS: Randomized controlled trials comparing refractive MIOL ReZOOM with diffractive MIOL ReSTOR were identified by searching CENTRAL, MEDLINE, EMbase, WANFANG MED ONLINE, CMJD, SinoMed, and CNKI. Related journals also were hand-searched. Methodological quality of randomized controlled trials ( RCTs ) was evaluated by simple evaluate method that recommended by the Cochrane Collaboration. Data extracted by two reviewers with designed extraction form. RevMan software ( release 5. 2 ) was used for data management and analysis.
RESULTS:A total of 7 trials (846 eyes) were included for systematic review. Subgroup analyses were used according to different model comparison of ReSTOR MIOL. The results showed a significant difference in the mean of the best distance corrected intermediate visual acuity ( BDCIVA) in the ReZOOM MIOL group with WMD=-0.11, 95% CI (-0.16, -0.06) (P<0.0001). It showed a significantly difference in the mean of the uncorrected near visual acuity ( UCNVA ) , complete spectacle independent rate, halo rate and glare rate in the ReSTOR MIOL group with WMD= 0. 09, 95% CI (0. 05, 0. 14) (P<0-00001), WMD= 2. 62, 95%CI (1. 76, 3. 91) (P<0. 00001), WMD=1. 35, 95% CI (1. 15, 1. 60) (P=0. 0004) and WMD=1-29, 95% CI (1. 09, 1. 53) (P= 0. 003). There was no significant difference between the two groups in the mean of the uncorrected distance visual acuity ( UCDVA ) , the uncorrected intermediate visual acuity ( UCIVA) , the best corrected distance visual acuity ( BCDVA ) and the best distance corrected near visual acuity ( BDCNVA ) with WMD-0.03, 95% CI (-0.06, 0.01) (P=0.15), WMD= -0.04, 95% CI (-0. 09, 0. 01) (P=0. 10), WMD= -0. 01, 95%CI (-0. 04, 0-02) (P=0. 55) and WMD= 0. 06, 95% CI (-0. 06, 0. 17) (P=0. 32).
CONCLUSION: Patients implanted with ReZOOM MIOL can provide better BDCIVA; patients implanted with ReSTOR MIOL show better UCNVA, are less likely to appear light halo, glare and other visual adverse reactions; correction in spectacles cases, patients implanted with ReZOOM or ReSTOR MIOL have considerable performances in the far and near visual acuity.