The conception of nutrition risk and malnutrition risk are not strictly differentiated in clinical.Nutri-tional risk was associated with a higher complications incidence,mortality and longer length of hospital stay.It′s nece-ssary to carry out nutrition risk screening to decide whether the need for nutritional intervention.This article introduces the clinical epidemiological characteristics of nutritional risk in children,nutrition risk score,nutritional risk screening, subjective global assessment,and screening tool for risk of impaired nutritional status and growth.It′s very important to apply a rapid and easy nutrition risk screening tools.Then,also discussions the relationship between nutritional risk screening and nutritional therapy,put forward on the strategies for assess and prevent malnutrition in children,and loo-king for the best way of nutritional support to ensure the body and cells metabolism,reduce the extent of tissue damage and promote the recovery of the disease.

Adult ; Female ; Foreign Bodies ; surgery ; Humans ; Neck ; Oropharynx ; surgery

BACKGROUND:Umbilical cord mesenchymal stem cels are from the umbilical cord of newly born individuals and have no ethical issues, and therefore are promising candidates for seeded cels as a substitute for cel transplantation and regenerative medicine. OBJECTIVE:To investigate the effects of serum from liver injury rats on induced differentiation of human umbilical cord mesenchymal stem cels into hepatocyte-like cels and provide experimental evidence for use of human umbilical cord mesenchymal stem cels in the treatment of patients with end-stage liver disease in the clinic. METHODS: Rat models of acute liver injury were established by intraperitoneal injection of 10% carbon tetrachloride. Rats in the control group were intraperitonealy administered the same amount of soybean oil. Forty-eight hours after modeling, abdominal aorta blood was taken for serum preparation. Passage 3 human umbilical cord mesenchymal stem cels were cultured with 20% serum from liver injury rats and 20% fetal bovine serum. Morphology of human umbilical cord mesenchymal stem cels was observed before and after culture. Levels ofα-fetoprotein and albumin in the supernatant were detected. RESULTS AND CONCLUSION:Cels exhibited shuttle-shaped appearance and grew in whirlpool-like manner at 1 day after culture with serum from liver injury rats, exhibited short shuttle-shaped appearance at 2 days, were oval-shaped at 3 days, and were round and an extremely smal number of cels were floated at 4 days. At 4 days after culture with serum from liver injury rats, level of albumin in the cel supernatant was significantly increased than that before induction and that in the control group (P< 0.001), and there was no significant difference in level of α-fetoprotein in the cel supernatant. These results suggest that serum of liver injury rats can induce differentiation of umbilical cord mesenchymal stem cels into hepatocyte-like cels.

Objective To observe the dynamic change of serum levels of perioperative procalcitonin (PCT ) ,C-reactive protein (CRP) ,interleukin 6(IL-6) and N-terminal brain natriuretic peptide(NT-proBNP) in the patients with lung cancer and to evaluate their value in postoperative monitoring .Methods Seventy-two patients with lung cancer were detected PCT ,CRP ,IL-6 and NT-proBNP levels before operation and on postoperative 1-5 d .The detection results were compared between the patients with cardiac injury and infection complications .Results Postoperative levels of serum PCT ,CRP ,IL-6 and NT-proBNP were increased in all the patients ;the peak value appearance of PCT ,CRP ,IL-6 and NT-proBNP in the patients with complications were earlier than that in the patients without complications ,moreover the peak value was significantly higher than that in the patients without complications (P<0 .05);the decrease speed of PCT ,CRP ,IL-6 and NT-proBNP in the patients with complications was slower than that in the patients without complications .Conclusion The combined detection of PCT ,CRP ,IL-6 and NT-proBNP may be become an effec-tive means to differentiate the postoperative complications .

Objective To explore the relation between serum nesfatin-1 ,tumor necrosis factor (TNF)-αand insulin resistance. Methods A total of 105 subjects were enrolled in this study and divided into two groups:patients with newly diagnosed type 2 diabetes mellitus (T2DM group,n= 64)and normal controls (NC group,n= 41). The fasting serum nesfatin-1 and TNF-αlevels were measured by enzyme-linked immuno sorbent assay (ELISA). FPG,HbA1 c,TG,TC,and FIns were also tested. BMI, HOMA-IR,HOMA-β,and ISI were calculated. Results Serum nesfatin-1 and TNF-αlevels were significantly higher in T2DM group than in NC group. Multiple linear regression analysis showed that the most significant influencing factors for nesfatin-1 were TNF-αand ISI(β= 0. 005、-6. 847,P<0. 05). The most significant influencing factors for TNF-αwas HbA1 c (β= 26. 652,P<0. 01). Conclusion Serum nesfatin-1 and TNF-αare significantly elevated in patients with newly diagnosed T2DM,which may influence the glucolipid metabolism through the signal pathway of insulin and play a role in the pathogenesis of T2DM and IR.

Objective To analyze the level of blood lipid in healthy Tibetans and Han natives in Lasa through the detection of serum lipids. Methods The serum TC, LDL-C, HDL-C and TG were detected by Hitachi 7060 automatic biochemical analyzer in 13 037 healthy adults (8 163 Tibetan individuals and 4 874 Han individuals). After that, all data were statistically analyzed by age (Tibetan:298 cases of ＜25 year-old group, 1 136 cases of 25-year-old group, 2 039 cases of 35-year-old group, 2 119 cases of 45-year-old group, 1 580 cases of 55-year-old group, 905 cases of 65-year-old group, 86 cases of ≥75 year-old group; Han population:307 cases of ＜25 year-old group, 1 254 cases of 25-year-old group, 1 874 cases of 35-year-old group, 1 022 cases of 45-year-old group, 272 cases of 55-year-old group, 129 cases of 65-year-old group, 16 cases of≥75 year-old group), sex (Tibetan: men 4 505 cases, women 3 658 cases; Han population:men 2 976 cases,women 1 898 cases). Results The average TC, HDL-C and LDL-C levels of Tibetans were (5.07 ± 1.10), ( 1.54 ±0. 49) and (3.33 ± 1.31 ) mmol/L respectively while the average levels of Han natives in Lasa were (4. 60 ± 0. 98 ), ( 1.45 ± 0. 44 ) and ( 2. 85 ± 1.0g ) mmol/L, which showed the levels of the Tibetans were higher than the Han natives in each age group(t =24. 78, 10. 53,21.46, P＜0.05). The TG levels was 1.38 ( 0. 20-2. 99 ) mmol/L in Tibetans and 1.54 (0.20-2.99)mmol/L in Han natives ( F = 224. 88, P ＜ 0. 05 ). The prevalence of total dyslipidemia was 75. 32% in Tibetans and 69. 02% in Han natives of Lasa. The prevalence of total dyslipidemia was 78. 56% in male and 65.42% in female. There were significant differences in both ethic and sex groups(x2 = 9. 678, 44. 138,P ＜0. 05). Conclusion The TC, LDL-C levels and prevalence of dylipidemia in Tibetans are higher than the Han residents in Lasa.

The architecture and environment of hospital are closely linked with the health of patients,which are of important ethical meaning.The layout,ward,waiting room,planting and decoration of a hospital should be centered on patients-oriented value to promote people's health.

Objective To analyse effect of Danhong injection on serum levels of bone markers and healing time in postoperative patients with tibial fractures.Methods 52 patients who were diagnosed with tibial fractures in our hospital were collected and randomly divided into control group and experimental group.All patients were treated with intramedullary nailing.After the operation, on the basis of routine treatment, patients in control group were treated with ossotide injection 50 mg, dissolved in 250 mL 0.9% sodium chloride solution, one times per day.Patients in experimental group was treated with Danhong injection 20 mL, dissolved in 250 mL 0.9% sodium chloride solution, one times per day.14 days for one period of treatment, two groups were treated for two cycles.After the treatment,the serum levels of bone Gla-protein (BGP), carboxyterminal propeptide of typeⅠprocollagen (PICP), bone alkaline phosphatase (BALP) and the racture healing time were detected in all patients.Results Compared with control group post-treatment, the serum BGP and PICP levels were higher in experimental group (P<0.05);the serum BALP level was higher in experimental group (P<0.05); the average fracture healing time of the patients in experimental group was shorter (P<0.05).Conclusion Danhong injection can significantly increase the serum BGP, PICP and BALP level in postoperative patients with tibial fractures, shorten fracture healing time.

Objective:To prepare dexketoprofen enteric-coated pellets and explore the drug release rate respectively in 0. 1 mol· L-1 hydrochloric acid and phosphate buffered saline(PBS,pH 6. 8). Methods:Dexketoprofen enteric-coated pellets were prepared u-sing fluid-bed coating technology, the blank sugar pellets were coated with drug layer, isolation layer and enteric layer in order. Drug-loading rate as the index, the optimal concentrations of HPMC and drug were screened. Such indicators as adhesion, pellet uniform and surface color as the indices, the coating process was optimized by orthogonal experiment. Drug release in PBS of the enteric-coated pel-lets and the common enteric-coated tablets were compared. Results:The prepared pellets showed the properties of uniform drug load-ing, high drug-loading rate, complete round shape and lustrous appearance. The concentration of HPMC and drug was 5% and 15%, respectively. The optimal coating process was as follows:the material temperature was 36℃, the atomization pressure was 1. 0 bar and the airbrush rate was 0. 8 ml·min-1 . The drug release of the pellets in hydrochloric acid was below 10% in 2 hours, while the release in PBS was greater than that of the common enteric-coated tablets. Conclusion: The prepared enteric-coated pellets are feasible in technology, and exhibit satisfactory acid endurance and drug release in vitro.

Sepsis is a major problem in the pediatric critical care medicine.The related research indi-cates that the nutrition risk may be one of the risk factors that affect the incidence and mortality of sepsis. Through nutritional risk screening and assessment,it can be used to provide reference for assessing the nutri-tional risk,the nutritional support and the effect of nutritional support on prognosis of children with sepsis.At present,there are few studies on the nutritional risk and nutritional support in children with sepsis.In this arti-cle,we reviewed the research progress on nutritional risk and nutritional support in children with sepsis.