BACKGROUND: Insulin-like growth factor-1 (IGF-1) has important biological effects on the heart, it can promote cardiac and vascular smooth muscle growth and metabolism.OBJECTIVE: To summarize the biological effects of IGF-1, to clarify the mechanism of exercise-induced cardiac hypertrophy, and make better use of the exercise influence on IGF1 to achieve adaptive cardiac hypertrophy.METHODS: With exercise-induced cardiac hypertrophy, insulin-like growth factor, exercise in English for the search terms,Pubmed database from January 1990 to April 2009 was retrieved; With exercise-induced cardiac hypertrophy, insulin-like growth factor, exercise in Chinese for the search terms, CNKI database from January 1990 to April 2009 was searched. Literatures were limited to English and Chinese languages. Inclusive criteria: animal experimental study and clinical application research closely linked to IGF-1; exclusive criteria: the old literatures and Meta analysis.RESULTS AND CONCLUSION: Totally 41 literatures were screened out by computers, according to the inclusion and exclusion criteria; 31 documents of which were involved for analysis. The IGF coordinates with other growth factors to promote differentiations and maturity of a variety of cells. The current data indicate that the blood serum and the cardiac local IGF-1 play an important role on cardiac hypertrophy. This study used the method of literature to analyze the production and action mechanism of the circulatory and cardiac IGF, discuss the functions of cardiac local IGF and the effect of exercise on it, and bring forward that exercise can alter the IGF expressions, IGF is related to the formation of exercise-induced cardiac hypertrophy.

Objective To investigate the characteristics of the clinic manifestations and the electromyogram changes in patients with chronic N2hexane intoxication. Methods The clinic manifestations, the electromyography and nerve conduction velocities were analyzed in 9 patients with N2hexane intoxi2 cation. Results The main clinical manifestations of the disease were acroparesthesia and asthenia, especially in legs. The abnormality rate of electromyography in patients with N2hexane intoxication was 100%. The conduction velocity of the sensory nerve and the motor nerve decreased at a rate of 33.33% and 88.89% respectively. The distal latencies were prolonged( 100% ). The denervated electromyogram was 33.33%. Conclusion The main clinical manifestations of the disease were Peripheral neuropathy. The chronic N2hexane intoxication mainly led to the imparement, especially in the distal region of the motor nerve in legs,and the damages of the nerve could be related to the duration of exposure to N2hexane.

Objective For arising recognition to HIE of neonate.We made a summary and a retrospective studied to CT material of 130 cases for neonate suffering HIE,combined with clinical diagnosis and documents.Methods 130 cases for neonate suffering HIE diagnosed by CT and clinic,all underwent unenhanced CT scan.Results Appearance of HIE:Normal involved 1～4 brain′s lobe,often involved frontal lobe;can be accompanied by kinds of intracranial hemorrhage;can be accompanied by infarction.Conclusion Among HIE cases,hypoxia and ischiemia were cause and result each other;difference among clinical symptoms and CT apearances are possible;the neonate with moderate and sereve asphyxia can be accompanied by intracranial hemorrhage more easier;to the injury of parasagittal region,CT and USG can not make a diagnosis.

Objective:To test the microtensile bonding strength between root canal wall and Bis-Core, and that between root canal wall and Chemil Superior glass-ionomer.Methods:10 human maxillary incisors extracted within one week were kept for another one week after root canal treatment and removeal of the crowns,each root was splited into two parts along with the long axis by Isomet saw, the bonding interface on one third of upside of root dentin smear layer was made with Diamond bur at a high-speed. Then Bis-Core and Chemil Superior glass-ionomer were put on root canal inner surface of each half part of the root respectively, samples with the size of 1.00 mm?1.00 mm were prepared by Isomet saw. Two samples in which bonding interface was perpendiculur to load were selected and fixed in Microtensile testing machine for bonding strength test. Results:Microtensile bonding strength(MPa) between Bis-Core and root canal inner wall and that between root canal inner wall and Chemil Superior glass-ionomer was 20.65?1.72 and 12.89?1.63 respectively(P

Objective:To observe the microstructure of interface between material and dentin after root canal rehabilitation. Methods:Three human maxillary incisors extracted within one week were used. After crowns being removed and received root canal treatment, they were used for the study. The root was split into two parts along the long axis, then the bonding interface was made with high speed diamond bur. Bis-Core and Chemil Superior glass-ionomer were stacked on root canal inner wall respectively and the teeth were split along with the long axis with Isomet saw, in order to expose bonding interface. The microstructure of bonding interface of the samples were analyzed by optical microscope and atomic force microscope(AFM). Results: AFM observation of the adhesive interface specimens showed that Chemil Superior glass-ionomer and teeth knitted together completely and no filling invaded into dentin tube. While the bonding interface between Bis-Core and dentin, dentin primer infiltrated into dentin tube and matrix around through the smear layer and colophony protruded. Conclusion:The observations reveal the extent of resin penetration into the dentinal tubules provides a very strong bonding. This is a fundamental cause of resin better bond to tooth.

BACKGROUND:The increase of serum cholesterol levels is positively correlated with the increasing incidence of osteoarthritis. Little is known about the role of high-fat diet in the degeneration of articular cartilage and induced arthritis.
OBJECTIVE:To observe the morphology change of the articular cartilage of New Zealand rabbits after high-fat diet, and explore the role of food in the articular cartilage degeneration.
METHODS:Forty New Zealand white rabbits were randomly divided into two groups. In control group, rabbits were fed with basal diet. In high-fat diet group, rabbits were fed with high-fat diet (20%lard and 80%basal diet). Fasting blood samples was taken every 4 weeks, to detect the triglyceride and total cholesterol levels. After rabbit were fed for 28 weeks, the knee joint was grossly observed and the femoral condyle cartilage was scanned by scanning electron microscope.
RESULTS AND CONCLUSION:Compared with the control group, the triglyceride and total cholesterol levels were significantly increased in the high fat group (P<0.05). Under scanning electron microscope, the high-fat group showed rough surface of condylar cartilage, shal ow pouch, messy arrangement, irregular shape and uneven size. The surface of cartilage exhibited focal denudation, irregular arrangement, uneven porosity and fractured cavity. Under higher magnification, smal mountain-like structure of cartilage surface became shal ow and flattened, the pores disappeared. Long-term high-fat diet may induce and aggravate cartilage damage, suggesting it may be involved in the pathogenesis of osteoarthritis.

Chronic obstructive pulmonary disease ( COPD) is a group of chronic airway inflammatory disease characterized by sustained airflow limitation and pulmonary function damage.Inflammation and tissue repair repeatedly result in airway remodeling.Now the mechanisms of airway remodeling remain unclear.More and more researches indicated that epithelial mesenchymal transition ( EMT) is crucial in the airway remodeling of COPD.EMT could be induced by various cell factors and signal channels in the airway epithelium, thus the airway remodeling happened.This review systematically introduces EMT and focuses on the relationship of EMT and airway remodeling of COPD and the probable mechanisms.

Objective To investigate the inter-arm invasive blood pressure differences during hip replacement in patients with lateral position and its relationship with position.Methods Sixty-six patients having underwent hip replacement in orthopedic surgery with lateral position were enrolled.Invasive blood pressure measurements were obtained from bilateral radial artery in all patients every 5 minutes.Simultaneously bilateral invasive blood pressure measurements were obtained and compared.Results At supine position,systolic pressure,diastolic pressure and mean arterial pressure of the uninjured side were (128.16 ±20.09),(69.47 ± 8.64) and (89.03 ± 10.42) mmHg (1 mmHg =0.133 kPa);systolic pressure,diastolic pressure and mean arterial pressure of the injured side were (127.90 ± 20.44),(69.86 ± 8.81) and (89.21 ± 10.71) mmHg.There was statistical difference in inter-arm diastolic pressure (P ＜ 0.05),but inter-arm systolic pressure and mean arterial pressure had no statistical differences (P ＞ 0.05).At left-lateral position,systolic pressure,diastolic pressure and mean arterial pressure of the uninjured side were (129.12 ± 21.93),(69.23 ± 8.92) and (89.19 ± 11.35) mmHg;systolic pressure,diastolic pressure and mean arterial pressure of the injured side were (129.01 ± 21.72),(69.51 ± 9.02) and (89.34 ± 11.35) mmHg.There was statistical difference in inter-arm diastolic pressure (P ＜ 0.05),but inter-arm systolic pressure and mean arterial pressure had no statistical differences (P ＞ 0.05).At right-lateral position,systolic pressure,diastolic pressure and mean arterial pressure of the uninjured side were (128.78 ± 20.34),(69.54 ± 9.06) and (89.29 ± 10.82) mmHg;systolic pressure,diastolic pressure and mean arterial pressure of the injured side were (128.27 ± 20.56),(70.00 ± 9.09) and (89.43 ± 10.89) mmHg.There were statistical differences in inter-arm systolic pressure and diastolic pressure (P ＜ 0.05),but inter-arm mean arterial pressure had no statistical difference (P ＞ 0.05).The bilateral radial artery blood pressure difference under different positions was ＜ 1 mmHg,and had no clinical practical significance.There was no correlation between blood pressure and age,sex,body mass index.Conclusion Bilateral radial artery in the same patients with invasive blood pressure has no clinical difference,and patients with lateral position operation for radial artery puncture pressure need not consider the differences of blood pressure between arms.

Objective To observe the therapeutic effect of hyper-laser irradiation combined with acupuncture for the treatment of temporomandibular joint disturbance syndrome(TMJDS).Methods Sixty TMJDS patients were equally randomized into two groups: the treatment group was given hyper-laser irradiation combined with acupuncture,and the control group given acupuncture alone.The treatment lasted 10 days.After treatment,the improvement of symptoms and signs in both groups was evaluated.Results The total effective rate was 93.3% in the treatment group and 80.0% in the control group,the therapeutic effect in the treatment group being superior to that in the control group(P

Reviews research findings about aberrant crypt foci on concepts, relation to colon carcinogenesis, relative genes and biomarkers, methods, signification. It shows that aberrant crypt foci are possible precursors of adenoma and cancer, which can be early diagnosis marks of colon carcinogenesis.