Objectives To compare the difference of blood mass spectrometry analysis between decompensated liver cirrhosis patients and compensated liver cirrhosis patients. Methods Thirty-four patients with decompensated liver cirrhosis and 47 patients with compensated liver cirrhosis were selected. All patients were analyzed by blood mass spectrometry, and the detected 93 parameters included amino acids, acylcarnitines and some of their ratios. Results After multivariate analysis using the 93 parameters, the two groups could be differentiated clearly. There were 32 parameters that contributed to the separation, which included 4 ratios. Logistic analysis showed that alanine, tetradecanoyl diacylcarnitine, tetradecenoylcarnitine, proline and serine could be used to separate the two groups sufficiently. Receiver operating characteristic curve analysis indicated that the area under the curve generated using the 5 parameters could reach to 0.99. Except alanine, the other 4 metabolites were all increased in the decompensated patients. Conclusions Blood mass spectrometry analysis could be used to differentiate decompensated and non- decompensated cirrhosis patients. The significantly changed metabolites might provide valuable hint in pathological study of the disease.

OBJECTIVE:To provide reference for breaking the“dual-track”system of the pharmacist and perfecting pharmacist system in China. METHODS:By reviewing laws and regulations relating to the pharmacist in recent 21 years,the implementation and problems of pharmacist system was investigated. RESULTS & CONCLUSIONS:The imperfection and dissonance of pharma-cist management regulations and laws system result in long-term“dual-track”system of pharmacist authentication. There still are other problems such as low rate of pharmacist registration and unbalanced regional distribution;unbalance between national li-censed pharmacist examination and examination condition of health systems pharmacist;divergence and mismatching between phar-macy education pharmacist training;social value of pharmacists cannot be reflected adequately. It is suggested to formulate Regula-tions on the Licensed Pharmacists as soon as possible,establish uniform and standard qualification and title appraisal system for na-tional pharmaceutical professional and technical personnel,promote licensed pharmacist classification registration and examination system reform,strengthen pharmacy education and licensed pharmacist training system reform,guide licensed pharmacist allocation rationally and orderly by various measures and enhance the propaganda of licensed pharmacist and their work,so as to promote the mergence of national licensed pharmacists qualification system and health professional technical pharmacist competence system.

Atrial Fibrillation ; surgery ; Catheter Ablation ; Humans

Objective:To explore the role of clinical pharmacists in the diagnosis and treatment of drug-induced diseases. Meth-ods:Clinical pharmacists analyzed the abnormal changes in the patients and looked for drug factors during the ward round with physi-cians. Results:Clinical pharmacists found drug-induced diseases and irrational drug use, and proposed the solutions accepted by phy-sicians. Conclusion:Clinical pharmacists should actively participate in the diagnosis and treatment of drug-induced diseases.

Objective In Caucasian populations, the tumor cells of Epstein Barr virus (EBV)-positive classical Hodgkin lymphoma (cHL) patients more frequently express HLA class Ⅰ and HLA class Ⅱ molecules compared to EBV-negative cHL patients. HLA expression (in relation to EBV) in Asian cHL patients has not been previously investigated. Methods 145 cHL patients with formalin-fixed, paraffin embedded tissue blocks available from Beijing, China were randomly selected. Hematoxylin & Eosin-stained slides were used to reclassify the histological subtypes according to the WHO classification. EBV status was determined by visualization of EBER in tumor cells using in situ hybridization. Membranous expression of HLA molecules was detected by immunohistochemistry using antibodies HC-10 (class Ⅰ heavy chain) and antiβ2-microglobulin for HLA class Ⅰ, and CR3/43 for HLA class Ⅱ. Results EBV (+) tumor cells were observed in 40 % (58/145) of the cHL patients. As expected, the percentage of EBV(+) cases was much higher in the mixed cellularity subtype (71%) than that in the nodular sclerosis subtype (16 %) (P ＜0.001). The expression of HLA class Ⅰ was observed in 79 % of the EBV (+) cHL cases and in 30 % of the EBV (-) cases (P ＜0.001). For HLA class Ⅱ, 52 % of EBV(+) cHL cases were positive, compared to 43 % in EBV(-) cases (P =0.277). Conclusion The results in China population were similar to that in the Caucasian population for HLA class Ⅰ, but not for HLA class Ⅱ.

OBJECTIVE To explore the quality control of disposable medical supplies,strengthen the management of disposable medical supplies.METHODS The procurement,inspection,storage,issuance,use,recycling,destruction,etc of the disposable medical supplies and aset of scientific managment procedures were developed. RESULTS Strengthening the management of disposable medical supplies,the occurrence of nosocomial infection and was reduced prevented the random loss of disposable medical supplies waste,to ensure safe and effective clinical use.CONCLUSIONS Hospital infection control and prevention of medical safety management are an important guarantee for strengthening the supervision of disposable medical supplies,and enhance the awareness of hospital infection control and prevention,which can be regarded as a modal of disposable medical supplies.

OBJECTIVE To explore the information-based management of disposable medical supplies, quality and performance of the medical production. METHODS Combined with successful experience of our hospital, the standardized management of disposable medical supplies in our hospital was introduced. RESULTS Real-time management of using and storage were undertaken to reduce the cost of the hospital. CONCLUSIONS It is available to build digital hospital and realize resources sharing between community hospitals utilizing computer and internet for whole range quality control of disposable medical supplies to obtain economic and social benefits.

OBJECTIVE To guarantee safe use of medical disposables for cure effect and life quality of the patients by tracing the quality of products and the patients lives.METHODS Combining with successful experience of our hospital,the process management for purchase of the disposable medical supplies were introduced.RESULTS By reducing the purchase price of medical consumables,lightening burden of patients,and through public bidding,the price of picked medical consumables was reduced widely.It was benefit to patients.CONCLUSIONS The price of the prodocts is reasonable and quality is reliable.Nevertheless,purchase process of medical consumables need to ameliorate.

fluconazole.Conclusion: The susceptibilities of Malassezia species to ketoconazole,itraconazole,and fluconazole are different.Microdilution method from M27-A is suitable for testing the susceptibility of Malassezia in vitro.