Humans ; Hypersensitivity

Humans ; Penicillins ; adverse effects ; immunology ; therapeutic use ; Skin Tests ; classification ; methods ; standards

Animals ; Apoptosis ; genetics ; immunology ; Apoptosis Regulatory Proteins ; genetics ; Autoimmune Lymphoproliferative Syndrome ; genetics ; immunology ; physiopathology ; Humans ; Mutation ; T-Lymphocytes ; immunology

Asthma ; prevention & control ; Child ; Humans ; Hypersensitivity ; prevention & control

Epilepsy is a common nervous system disease,with a morbidity of 4.8‰-11.2‰,so there has been about 50 million patients globally.Drug treatment is a major mean to treat epileptic patients.Recently,researches illustrated that cellular immunity disorder and humoral immunity disorder were coexist in epleptic patients,but there was no consensus on whether it was induced by anti-epileptic drugs(AEDs) or epilepsy itself up to now.This article is aimed to explain the impact of AEDs on immunity through review recent literature internal and abroad.

Calcineurin ; metabolism ; Cardiovascular System ; growth & development ; metabolism ; Humans ; NFATC Transcription Factors ; metabolism ; Signal Transduction

Cephalosporins ; adverse effects ; therapeutic use ; Humans ; Infant, Newborn ; Penicillins ; adverse effects ; therapeutic use ; Skin Tests

Contraindications ; Humans ; Infant ; Infant, Newborn ; Promethazine ; adverse effects ; therapeutic use

Air ; Humans ; Workplace

OBJECTIVE: To investigate and analyze the problems in information for children existing in package inserts of medications commonly used in pediatrics in 15 hospitals and try to establish a template and provide reference for standardizing package inserts of medications in China. METHODS: The method of text analysis and literature survey were used. Information for children in the package inserts were collected, analyzed and evaluated according to Guidance for Industry and Review Staff; Pediatric Information Incorporated Into Human Prescription Drug and Biological Products Labeling (Draft) issued by U.S. FDA and other references. RESULTS: In 660 package inserts of 338 medications, 8.0%, 56.9%, 16.4%, 11.7% and 45.8% contained the information on children's indications, dosages and administrations, adverse drug reactions, contraindications and precautions, respectively, while only 2.3% had information of pediatric clinical trials or children's pharmacokinetic data CONCLUSION: The current information for Children in package inserts are insufficient and lack of standards, so further management should be strengthened to improve the situation.