Objective To evaluate the role of PI3K-Akt-HIF-1α signaling pathway in dexmedetomidine-induced reduction of damage to the unventilated lung during one-lung ventilation (OLV) in rats.Methods Forty adult male Sprague-Dawley rats,weighing 250-350 g,were randomly divided into 4 groups (n=10 each) using a random number table:two-lung ventilation TLV) group,OLV + normal saline group (group OLV),OLV + dexmedetomidine group (group D),and OLV + dexmedetomidine +LY294002 group (group DL).Bilateral lungs were ventilated for 2.5 h in group TLV,and the right lung was ventilated for 2 h followed by 0.5 h TLV in the other groups.The rats were sacrificed,the left lung was removed for determination of wet to dry lung weight ratio (W/D ratio),and expression of phosphorylated Akt (p-Akt) and hypoxia-inducible factor-1 alpha (HIF-1α) (by Western blot).Results Compared with group TLV,W/D ratio was significantly increased,the expression of p-Akt was down-regulated,and the expression of HIF-1α was up-regulated in the other three groups (P＜0.05).Compared with group OLV,W/D ratio was significantly decreased,and the expression of p-Akt and HIF-lα was up-regulated in D and DL groups (P＜0.05).Compared with group DL,W/D ratio was significantly decreased,and the expression of p-Akt and HIF-1α was up-regulated in group D (P＜0.05).Conclusion PI3K-Akt-HIF-1α signaling pathway is involved in dexmedetomidine-induced reduction of damage to the unventilated lung during OLV in rats.

Asia ; epidemiology ; Humans ; Non-alcoholic Fatty Liver Disease ; epidemiology ; Prevalence

DICOM standard is a compulsory international standard for the establishment of Integrated Hospital Information System (IHIS) and Picture Archiving and Communication System (PACS). This paper introduces such information of DICOM3.0 as its generation, components, operational mechanism and application. To understand DICOM standard exactly is helpful for the efficient operation of PACS.

The deposition of amyloid β-protein (Aβ is the key pathological basis of cerebral amyloid angiopathy (CAA) and Alzheimer's disease (AD). The current studies emphasis that the stability of internal environment between cells of the neurovascular unit is the key to maintain normal brain function. This article reviews the relationship between the Aβand the neurovascular unit injury, and we expect to provide some new ideas for the clinical prevention and treatment of CAA and AD.

There are many therapeutic drugs for rheumatoid arthritis(RA) treatment,but the pathogenesis of RA have not been fully understood,therefore no curable drug has been found.With increasing knowledge of the inflammatory process,especially in signaling,some drugs modifying disease progress and interfering signaling pathways have been studied.Cytokine inhibitors such as tumor necrosis factor-blocking agents and IL-1 receptor antagonist in clinical trials and in practice have resulted in dramatic improvement in RA disease control.Important molecular mechanisms of actions on total glucosides of paeony(TGP) and Glucosides of Chaenomeles speciosa(GCS) were showed to modulate G protein-AC-cAMP and Ras-MAPKs signaling pathways and to inhibit synoviacytes proliferation.This review focuses on agents which target various cytokines,other inflammatory mediators,antigen of cells,and signaling pathways.

Objective To study the physiochemical properties of selenium exopolysaccharide from Porphyridium sp.(Se-PSP).Methods The Se-PSP was obtained from ASW,a sort of culture medium added with some selenious acid solution,and was purified by DEAE-52 cellulose column and identified by Sephadex G-200.The acidity,UV spectral absorption,paper chromatography,and gelose electrophoresis of Se-PSP solution were studied.Results and Conclusion Proper concentration of selenious acid in ASW culture had no influences upon the growth of Porphyridium.Se-PSP prepared in this way didn't contain protein and nucleic acid and the solution of Se-PSP showed acidity.It is probable that Se-PSP contain two fractions of PSP.

Objective To summarize the experiences of logistics support in disaster areas stricken by the catastrophic Wenchuan earthquake with the aim to improve the ability to effectively meet various military missions. Methods The experiences of logistics support in disaster areas stricken by the catastrophic Wenchuan earthquake were reviewed and analyzed retrospectively. With the author's knowledge of commanding the health service in rescue work, a proposal was put forward on the organization of military logistics and health support to effectively meet various military missions in the future. Results The disaster areas stricken by the strong Wenchuan earthquake were about 500 thousand km2, in which about 130 thousand km2 areas were heavily stricken, and about 4.3 million casualties needed to be treated. The peculiarities of the rescue support in the disaster areas were as follows: urgency in mission, difficulty in coordination, urgent and rapid changes in tasks, and difficelty in ensuring supply. For the military logistic service, the specific services in disaster areas were: to strictly carry out the commands from high authorities and determination to carry out the rescue work of health support; to unify the commands, and coordinate as a whole to enhance the efficiency of health service command; to carry out rational deployment of medical teams and rapidly organize a combined military and civilian medical support system; to dexterously utilize every single resource of health service, and continuously enhance the efficiency of health service. By means of high efficiency of health service, the fighting capacity of troops in carrying out the task had been withheld and enhanced, ensuring timely treatment of the injured, and no outbreak of epidemic, which used to prevail after a strong earthquake. Conclusions In view of existing problems in medical support in rescuing the casualties in this disaster, such as insufficient preparedness of health service in dealing with catastrophic natural disaster, imperfect organization and coordination system, and backward in equipments and techniques, and the prospects that the necessity of developing military health service to meet the needs of various military tasks in the future, it is suggested that: the capacity to respond to meet sudden accidents should be honed, capacity of coordinated action in carrying out tasks by combined forces should be enhanced; the levels of surgical expertise and medical support should be elevated, and the construction of logistics forces should be strengthened.

Objective To provide references for clinical medication through the analysis on the dose-response relationship and compatibility medication rules of Cinnamomi Ramulus.Methods It systematically arranged the provisions containing Cinnamomi Ramulus inShang Han Lun. Relationship between the dose of Cinnamomi Ramulus and the related factors were analyzed by single factor logistic regression analysis and binary correlation analysis by SPSS20.0 statistical software.Results After screening, 40 prescriptions including Cinnamomi Ramulus were selected, accounting for 35.40% in the total prescriptions ofShang Han Lun. The taken dose of every time of Cinnamomi Ramulus had a close relationship with the number of medicine and water consumption, with statistical significance (P=0.000,P=0.004). However, it had no relationship with residual water, water consumption per time and use frequency, without statistical significance (P>0.05). Single factor logistic regression analysis showed whether Cinnamomi Ramulus as a mainmedicine had the close relationship with the taken dose of every time of Cinnamomi Ramulus and use frequency (P=0.008,P=0.043). When Cinnamomi Ramulus and Glycyrrhizae Radix et Rhizoma Praeparata cum Mella were in compatibility, compared with when Cinnamomi Ramulus was not the main medicine, the taken dose of every time of Cinnamomi Ramulus as the main medicine in the group was more frequently used, with statistical significance (P=0.046); however, the number of medicine was statistically lower than when Cinnamomi Ramulus was not main medicine (P=0.043). When Cinnamomi Ramulus and Ephedrae Herba were in compatibility, there was no statistical difference in the taken dose of every time of Cinnamomi Ramulus or the number of medicine (P>0.05). When Cinnamomi Ramulus was the main medicine, it was not in compatibility with Poria or Bupleuri Radix.ConclusionFrom the dose-response relationship, it can be found that the use and compatibility of Cinnamomi Ramulus inShang Han Lun are strict and flexible, and dose law can provide a basis for clinical application.

This paper briefly reviewed the history and current development of traditional Chinese medicine(TCM)in the United Kingdom and introduced TCM associations and TCM colleges and universities in detail in this country.This paper provided a reference for comprehensively understanding the current TCM associations.education and researching institutes in the United Kingdom.