Glomangiosarcoma is a histopathologically defined extremely rare malignant tumor that accompanies a glomus tumor usually, but its has benign clinical course characteristically. It shares common ultrastructural and immunohistochemical features with glomus tumor, and transformed possibly from glomus tumor". Glomangiosarcoma shows more sarcomatous appearance histologically than glomus tumor, however with no malignant behavior(i.e. recurrence or metastasis) was expressed. We experienced a case of glomangiosarcoma form subungual region treated by marginal excision and no recurrence or metastasis was developed untill 1 year and 6 months postoperatively.
Glomus Tumor ; Neoplasm Metastasis ; Recurrence

Primary CNS rhabdoid tumor is an extremely rare malignant tumor affecting children. Clinical, radiological, and histopathological features of malignant rhabdoid tumor are presented. Following the complete extirpation of a large tumor at the frontoparietal region, a 16-year-old male patient suffered from several local recurrences. The neoplasm is, defined by its histopathological and ultrastructural characteristics and by the pattern of its antigenicity as a malignant rhabdoid tumor(MRT).
Adolescent ; Child ; Humans ; Male ; Recurrence ; Rhabdoid Tumor*

We report a case of subungual solitary glomus tumor in a 28-year-old female, who has suffered from pain and tenderness of the left 4th finger tip for about 5 years. Simple surgical excision was performed for removal of the tumor mass and for the relief of the subjective symptoms. No recurrence has been observed for 5 months following excision of the tumor.
Adult ; Female ; Fingers ; Glomus Tumor* ; Humans ; Recurrence

Background and Objective: Epidemiological studies have shown that Filipinos have a higher prevalence of welldifferentiated thyroid cancer and a higher rate of recurrence. The BRAF V600E mutation has been proposed as a potential prognostic marker in aggressive papillary thyroid cancers. In this study, we determined whether this mutation is a risk factor for tumor recurrence in papillary thyroid cancer among Filipinos. Methods: We conducted an age and sex-matched case-control study of patients with papillary thyroid cancer; we had two groups – with and without tumor recurrence – of 14 patients each, with at least a 5-year follow-up. We extracted the DNA samples from the patients’ (paraffin-embedded) tumor biopsy tissue blocks from thyroidectomy specimens, then detected the BRAF V600E mutation using polymerase chain reaction. The McNemar’s test for difference of proportions in paired data was used to determine the association of BRAF V600E mutation with recurrence. Results: The BRAF V600E mutation was found in 57.14% of all cases. We found a prevalence of 64.29% among those with recurrence and 50.00% among those without recurrence, with no significant difference between the two groups (p = 0.688). Conclusion Our study showed the BRAF V600E mutation was not associated with recurrence. We encountered several limitations: we had limited data regarding molecular methodologies in the Philippine setting, we had a small sample size, and therefore we could not study other parameters (e.g., tumor characteristics, lymph node metastasis, stage of disease). We hope that this paves the way for future studies and collaborations to establish the role of BRAF V600E in Filipinos with papillary thyroid tumor recurrence.
papillary thyroid cancer ; molecular diagnostics ; tumor recurrence

Condyloma acuminatum, a benign disease caused by a filtrable virus, occurs predominantly in the perianal andgenital areas. The lesions are noninvasive but are subject to recurrence. In rare instances, a more aggresive formof this disease, known as "giant condlyloma acuminatum" or "Buschke-Lownestein tumor", occures. In this form,infiltration of the lesion into surrounding structures takes place. This tumor has been reported to occurprincipally in the genitourinary tract. The authors experienced a cases of giant condyloma acuminatum originatingfrom rectum in 67 years old male patient which recurred 3 months after electrofulguration.
Buschke-Lowenstein Tumor ; Humans ; Male ; Rectum ; Recurrence

PURPOSE: A glomus tumor is a rare tumor with predilection for the hand. The curative treatment is complete surgical excision. Transungual approach is one of usual options for subungual glomus tumor, but the major complication of this method is nail deformity. The authors describe the different operation to avoid this complication. MATERIALS AND METHODS: From April, 2005 to May, 2009. 9 patients were diagnosed with digital glomus tumors. 8 patients were underwent excision with transungual open window exposing nail bed using partial detachment of nail plate. In all patients, preoperative clinical diagnosis was confirmed postoperatively with the biopsy result. RESULTS: All cases were followed up for average 4.2month(range 6 weeks to 13 months). Symptoms were improved after surgery. No complication and recurrence were occurred. There were no nail deformities by this altered approach. CONCLUSIONS: This altered technique with partial detached nail plate represent a safe and effective result to excise digital glomus tumors in subungual lesion.
Biopsy ; Congenital Abnormalities ; Glomus Tumor ; Hand ; Humans ; Nails ; Recurrence

BACKGROUND: The purpose of this study is to compare the efficacy and safety of multisession radiosurgery to those of single dose radiosurgery for metastatic brain tumors. METHODS: Between February 2008 and February 2012, 90 patients with 196 metastatic brain tumors were treated with cyberknife radiosurgery, and we reviewed these patients retrospectively. Among them, 57 patients underwent single dose radiosurgery, and 33 patients multisession radiosurgery. Tumors involving the eloquent area and large tumors (>5 cc) were treated with multisession radiosurgery. The median tumor volume and the median treatment dose of single dose radiosurgery were 2.05+/-0.72 cc and 19.76+/-1.54 Gy respectively, and in the case of multisession radiosurgery, 5.30+/-1.70 cc and 29.6+/-1.70 Gy respectively. The frequency of multisession dose was 3 to 5 times, on average 3.55 times, and 8.91 Gy were given per 1 session on average. RESULTS: The overall survival (OS) of multisession radiosurgery was 16.0 months, whereas that of single dose radiosurgery was 11.5 months. The radiologic tumor response rates were 90% in single dose radiosurgery and 95.4% in multisession radiosurgery, respectively. Over 6-month and 1-year periods, the OS rates of single dose radiosurgery were 71.4% and 44.9%, whereas those of multisession radiosurgery were 69.1% and 58.3%, respectively (p=0.83). Toxicities were seen in 18.1% in the single dose radiosurgery group versus 4% in the multisession radiosurgery group. The difference was significant (p<0.05). CONCLUSION: In this study, the multisession radiosurgery group, despite the location and size constraints, did not differ from the single dose radiosurgery group when comparing the survival and recurrence rates, but complications and toxicity were lower. Thus, multisession radiosurgery is thought to be beneficial for treatment of large tumors and tumors located in the eloquent area.
Brain Neoplasms* ; Brain* ; Humans ; Radiosurgery* ; Recurrence ; Retrospective Studies ; Tumor Burden

A squamous odontogenic tumor (SOT) is an epithelial originated benign tumor. It has been rarely reported and most was intramural type. We observed a case of SOT in the mandible. It was associated with the odontogenic cyst. It was shown positive to pancytokeratin and p53. Considering that the case was free from recurrence for 5 years after surgery, p53 positive did not seem to be related to the prognosis of the disease.
Mandible ; Odontogenic Cysts ; Odontogenic Tumor, Squamous* ; Prognosis ; Recurrence

PURPOSE: The usefulness of serum tumor markers for assessing gastric carcinoma is very limited compared to that for neoplasms in other digestive organs. Many reports have shown that serum tumor markers are closely associated with the prognosis and tumor recurrence in gastric cancer patients. However, little is known about the usefulness of serum tumor markers as a predictor of distant metastasis for gastric carcinoma. MATERIALS AND METHODS: With excluding the non-specific causes of elevated tumor markers, a total of 788 patients with gastric carcinoma and who were seen at our hospitals between 2004 and 2006 were included in this study. The correlation between the preoperative level of tumor makers and the clinicopathological features was analyzed. RESULTS: CEA was significantly correlated with age, gender and nodal metastasis, but not with the depth of tumor. The CEA level was not correlated with distant metastasis, such as peritoneal or hematogenous metastasis. In contrast, the CA 19-9 level was significantly correlated not only with the depth of tumor and nodal metastasis, but also with peritoneal metastasis. Especially, the patients with over 500% elevation of the CA 19-9 level had a significant risk of peritoneal metastasis. CONCLUSION: CA 19-9 is useful for predicting peritoneal metastasis in gastric cancer patients. It can be used efficiently in making the diagnostic and the treatment plan, in combination with other diagnostic tools, for gastric cancer patients.
Humans ; Neoplasm Metastasis ; Prognosis ; Recurrence ; Stomach Neoplasms ; Biomarkers, Tumor

Adenomatoid tumor of uterus is described by Golden and Ash as a tumor that similar to adenoma but found obscured histogenesis. Adenomatoid tumor is a rare benign disease that originated from mesothelium and mostly occurred in male and rarely in female, and can be treated by simple excision of tumor because there is no recurrence or malignant change. We describe the clinical and histologic findings with references to other reported cases. We herein report a case of adenomatoid tumor of the uterus that gets an operation under clinical impression of myoma uteri.
Adenoma ; Adenomatoid Tumor ; Epithelium ; Female ; Humans ; Male ; Myoma ; Recurrence ; Uterus