Glomangiosarcoma is a histopathologically defined extremely rare malignant tumor that accompanies a glomus tumor usually, but its has benign clinical course characteristically. It shares common ultrastructural and immunohistochemical features with glomus tumor, and transformed possibly from glomus tumor". Glomangiosarcoma shows more sarcomatous appearance histologically than glomus tumor, however with no malignant behavior(i.e. recurrence or metastasis) was expressed. We experienced a case of glomangiosarcoma form subungual region treated by marginal excision and no recurrence or metastasis was developed untill 1 year and 6 months postoperatively.
Glomus Tumor ; Neoplasm Metastasis ; Recurrence

Primary CNS rhabdoid tumor is an extremely rare malignant tumor affecting children. Clinical, radiological, and histopathological features of malignant rhabdoid tumor are presented. Following the complete extirpation of a large tumor at the frontoparietal region, a 16-year-old male patient suffered from several local recurrences. The neoplasm is, defined by its histopathological and ultrastructural characteristics and by the pattern of its antigenicity as a malignant rhabdoid tumor(MRT).
Adolescent ; Child ; Humans ; Male ; Recurrence ; Rhabdoid Tumor*

We report a case of subungual solitary glomus tumor in a 28-year-old female, who has suffered from pain and tenderness of the left 4th finger tip for about 5 years. Simple surgical excision was performed for removal of the tumor mass and for the relief of the subjective symptoms. No recurrence has been observed for 5 months following excision of the tumor.
Adult ; Female ; Fingers ; Glomus Tumor* ; Humans ; Recurrence

Condyloma acuminatum, a benign disease caused by a filtrable virus, occurs predominantly in the perianal andgenital areas. The lesions are noninvasive but are subject to recurrence. In rare instances, a more aggresive formof this disease, known as "giant condlyloma acuminatum" or "Buschke-Lownestein tumor", occures. In this form,infiltration of the lesion into surrounding structures takes place. This tumor has been reported to occurprincipally in the genitourinary tract. The authors experienced a cases of giant condyloma acuminatum originatingfrom rectum in 67 years old male patient which recurred 3 months after electrofulguration.
Buschke-Lowenstein Tumor ; Humans ; Male ; Rectum ; Recurrence

Background and Objective: Epidemiological studies have shown that Filipinos have a higher prevalence of welldifferentiated thyroid cancer and a higher rate of recurrence. The BRAF V600E mutation has been proposed as a potential prognostic marker in aggressive papillary thyroid cancers. In this study, we determined whether this mutation is a risk factor for tumor recurrence in papillary thyroid cancer among Filipinos. Methods: We conducted an age and sex-matched case-control study of patients with papillary thyroid cancer; we had two groups – with and without tumor recurrence – of 14 patients each, with at least a 5-year follow-up. We extracted the DNA samples from the patients’ (paraffin-embedded) tumor biopsy tissue blocks from thyroidectomy specimens, then detected the BRAF V600E mutation using polymerase chain reaction. The McNemar’s test for difference of proportions in paired data was used to determine the association of BRAF V600E mutation with recurrence. Results: The BRAF V600E mutation was found in 57.14% of all cases. We found a prevalence of 64.29% among those with recurrence and 50.00% among those without recurrence, with no significant difference between the two groups (p = 0.688). Conclusion Our study showed the BRAF V600E mutation was not associated with recurrence. We encountered several limitations: we had limited data regarding molecular methodologies in the Philippine setting, we had a small sample size, and therefore we could not study other parameters (e.g., tumor characteristics, lymph node metastasis, stage of disease). We hope that this paves the way for future studies and collaborations to establish the role of BRAF V600E in Filipinos with papillary thyroid tumor recurrence.
papillary thyroid cancer ; molecular diagnostics ; tumor recurrence

Adenomatoid tumor of uterus is described by Golden and Ash as a tumor that similar to adenoma but found obscured histogenesis. Adenomatoid tumor is a rare benign disease that originated from mesothelium and mostly occurred in male and rarely in female, and can be treated by simple excision of tumor because there is no recurrence or malignant change. We describe the clinical and histologic findings with references to other reported cases. We herein report a case of adenomatoid tumor of the uterus that gets an operation under clinical impression of myoma uteri.
Adenoma ; Adenomatoid Tumor ; Epithelium ; Female ; Humans ; Male ; Myoma ; Recurrence ; Uterus

BACKGROUND: Phyllodes tumors are relatively rare fibroepithelial tumors of the breast. There are no strict criteria for the classification of benign and malignant phyllodes tumor. The recurrence rate is relatively high, and no single criterion for predicting recurrence has yet been established. In an attempt to define the clinical features and their histopathological correlations, we have reviewed a total of 38 patients with original pathological diagnoses of cystosarcoma phyllodes and phyllodes tumors. METHODS: Thirty-eight cases of phyllodes tumors were reviewed. Microscopic slides were re-examined and reclassified using newly defined histologic criteria which were modified from those of Pietruszka et al. The pathologic criteria examined were the number of mitoses, the invasiveness of the tumor border, the stromal overgrowth, and the stromal cellular pleomorphism. The clinical features evaluated included age, incidence, clinical manifestation, surgical procedure, and recurrence. RESULTS: The mean age was 34.9 +/- 12.4 years with the peak age between 40 and 49. The yearly incidence trend showed a slow increase. Twenty-three tumors (62%) fullfilled the criteria for benign phyllodes tumors, seven tumors (19%) were borderline, and seven tumors (19%) were malignant. The mean ages of the patients with benign, borderline, and malignant phyllodes tumors were 31.9, 39.1, and 40.9 years, respectively. The sizes of the benign phyllodes tumors were smaller than those of the borderline or the malignant tumors. Recurrence was found after initial excision in two patients with benign phyllodes tumors. However, after an initial wide excision, there was no recurrence in five patients with borderline and malignant tumors. CONCLUSIONS: There were no dependable histopathological features to predict recurrence; that is, histologic type does not influence the rate of recurrence or the prognosis after an adequate excision.
Breast* ; Classification ; Diagnosis ; Humans ; Incidence ; Mitosis ; Phyllodes Tumor* ; Prognosis ; Recurrence

A squamous odontogenic tumor (SOT) is an epithelial originated benign tumor. It has been rarely reported and most was intramural type. We observed a case of SOT in the mandible. It was associated with the odontogenic cyst. It was shown positive to pancytokeratin and p53. Considering that the case was free from recurrence for 5 years after surgery, p53 positive did not seem to be related to the prognosis of the disease.
Mandible ; Odontogenic Cysts ; Odontogenic Tumor, Squamous* ; Prognosis ; Recurrence

PURPOSE: A glomus tumor is a rare tumor with predilection for the hand. The curative treatment is complete surgical excision. Transungual approach is one of usual options for subungual glomus tumor, but the major complication of this method is nail deformity. The authors describe the different operation to avoid this complication. MATERIALS AND METHODS: From April, 2005 to May, 2009. 9 patients were diagnosed with digital glomus tumors. 8 patients were underwent excision with transungual open window exposing nail bed using partial detachment of nail plate. In all patients, preoperative clinical diagnosis was confirmed postoperatively with the biopsy result. RESULTS: All cases were followed up for average 4.2month(range 6 weeks to 13 months). Symptoms were improved after surgery. No complication and recurrence were occurred. There were no nail deformities by this altered approach. CONCLUSIONS: This altered technique with partial detached nail plate represent a safe and effective result to excise digital glomus tumors in subungual lesion.
Biopsy ; Congenital Abnormalities ; Glomus Tumor ; Hand ; Humans ; Nails ; Recurrence

BACKGROUND: The purpose of this study is to compare the efficacy and safety of multisession radiosurgery to those of single dose radiosurgery for metastatic brain tumors. METHODS: Between February 2008 and February 2012, 90 patients with 196 metastatic brain tumors were treated with cyberknife radiosurgery, and we reviewed these patients retrospectively. Among them, 57 patients underwent single dose radiosurgery, and 33 patients multisession radiosurgery. Tumors involving the eloquent area and large tumors (>5 cc) were treated with multisession radiosurgery. The median tumor volume and the median treatment dose of single dose radiosurgery were 2.05+/-0.72 cc and 19.76+/-1.54 Gy respectively, and in the case of multisession radiosurgery, 5.30+/-1.70 cc and 29.6+/-1.70 Gy respectively. The frequency of multisession dose was 3 to 5 times, on average 3.55 times, and 8.91 Gy were given per 1 session on average. RESULTS: The overall survival (OS) of multisession radiosurgery was 16.0 months, whereas that of single dose radiosurgery was 11.5 months. The radiologic tumor response rates were 90% in single dose radiosurgery and 95.4% in multisession radiosurgery, respectively. Over 6-month and 1-year periods, the OS rates of single dose radiosurgery were 71.4% and 44.9%, whereas those of multisession radiosurgery were 69.1% and 58.3%, respectively (p=0.83). Toxicities were seen in 18.1% in the single dose radiosurgery group versus 4% in the multisession radiosurgery group. The difference was significant (p<0.05). CONCLUSION: In this study, the multisession radiosurgery group, despite the location and size constraints, did not differ from the single dose radiosurgery group when comparing the survival and recurrence rates, but complications and toxicity were lower. Thus, multisession radiosurgery is thought to be beneficial for treatment of large tumors and tumors located in the eloquent area.
Brain Neoplasms* ; Brain* ; Humans ; Radiosurgery* ; Recurrence ; Retrospective Studies ; Tumor Burden