Sustained release film coated tablets containing dexchlorpheniramine maleate were prepared in such a structure as two-third of drug were dispersed in Eudragit RS 100 to form insoluble matrix that gradually releases drug by diffusional mechanism, the rest was dispersed in the immediate release part. The core tablets were compressed by a wet granulation process and the film coated tablets by a routine film coating process with Eudragit E suspension. The formed coated tablets have suitable technical characteristics. The third formulation with Eudragit RS- drug ratio 2:1 has got the dissolution extent and the release rate in vitro similar to those of Polaramine 6mg repetabs. They also meet the requirements invitro release rate versus time for sustained release capsules containing Chlorpheniramine maleate by USP XXIII. Therefore, these film coated tablets with dexchlorpheniramine maleate may be candidates for a sustained release dosage form
dexchlorpheniramine ; Tablets

Quantitation of Metronidazole by reversed phase liquid chromatography using Supelco LC-ABZ column and a mobile phase containing an acid aqueous phase (pH Metronidazole ; Tablets

Study on some methods used to quantify berberine chloride showed that the UV measuring and volumetric titration methods did not express only amount of berberine chloride itself. It is necessary to apply high- performance liquid chromatography (HPLC) to achieve the optimal conditions for better splitting, higher accuracy…in order to apply more widely in testing products commonly in market with many components combined to berberine chloride. To find out optimal methods, which are suitable with condition of present some pharmaceutical units, it is necessary to experiment continuously methods such as UV measuring and volumetric titration,… using HPLC method to compare.
Berberine ; Tablets

The effect of Ha Noi College of Pharmacy producted CTK tablet containing 0.5g CTK mixed powder on bacterial utero-vaginitis was studied on 31 female married subjects aged 18-44. Chloramphenicol 0.25g tablet producted by Central pharmaceutical Factory N2 was used control. Results showed that CTK tablet manifests antibacterial effect compared with chloramphenicol in utero-vaginitis. Antibacterial effect is 65.4% by a dose of treatment (20 times of application of tablet). The effect of healing the lesion was manifested earlier than that of chateravaginitisull
Tablets ; Vaginitis ; Bacterial Infections

Using the full quadratic model in drug dissolution optimization, the authors built up the sustained release of diclofenac tablet formulation with hydrophilic matrix excipient. The sustained excipient releases xanthan gum which has good features such as controlling medical substance regularly, rubbing seed easily, covering tablet easily and compressed force with a little affect to the rate of medical substance release. This formulation can be applied in making up medicines with a wider scale. It is being tested its stability and evaluated its availability to apply in manufacture
Diclofenac, Pharmaceutical Preparations , Tablets

The capacity of dissolution of active component of the tablet of ciproflaxacin. 6 samples composing of 78 domestic and foreign ciprofloxacin tablet were tested. Results showed that 2 of 3 samples of domestic tablet did not meet the requirement for dissolution mentioned to USP XXIII, while the foreign tablets manifested a rate of dissolution higher than that of pharmacopea
Ciprofloxacin ; Pharmaceutical Preparations ; Tablets

Study on 12 healthy volunteers using 2 types of medication: rifampicin, isoniazid, and pyrazinamid standard separate tablets and in fixed dose combination of rifampicin + isoniazid + pyrazinamid (3- FDC). Results: rifampicin is one of essential anti-tuberculosis drugs that have most advantages of pharmacodynamics on both intra- and extra-cellular bacteria. Cmax (maximum concentration in plasma) and AUC 0-∞ (Area Under the Concentration-Time Curve) of rifampicin in 3- FDC is lower than that in standard separate tablet, Tmax (Time to Maximum Plasma Concentration) of rifampicin in 3- FDC is more slowly than in standard separate tablet. These findings showed that the bioavailability of rifampicin in FDC tablet that was using in treating tuberculosis is much lower than in standard separate tablet.
Biological Availability ; Rifampin ; Tablets

Preliminary application of fluorescerin spectrum to analyze riboflavine in Aphavita filmed tablet. Aphavita was a combination of vitamins B1, B6, B5, PP and adjuvants. Basing on the fluorescein property of ribofleavine, which depends on pH of tested media, the product was quantified. The qualitification showed the line criterion, the repeatation and the accuracy
Riboflavin ; Pharmaceutical Preparations ; Tablets

Full Spectrum Quantification technique gained fast, accurate results without extraction. This conforms to analysis of drug samples on the market. Results proved the method was accurate and has the acceptable reproducibility
Acetaminophen ; Ibuprofen ; Tablets

Theophylline tablets with release action (Theo KD) was tested in dosage 100mg x 2 tablets a time each 12 hours for asthma patients, and was compared to 100mg THEOSTAT tablet with release action of Laboratoiries INAVA (France). Results: Theo KD was suitable in the treatment of 2 0r 3 degree asthma. ADRs were minor and temporary. No one stopped treatment due to ADRs
Theophylline ; Tablets ; Chemistry