Objectives To observe the co-activation phenomenon during exercise fatigue induced by the proximal muscles on the upper limbs.Methods Sixteen undergraduates not majoring in sports participated in this study,and their left arms were chosen as the observed arms and right arms were selected as the weighted arms.The weighted arm was alternatively in the state of relaxation without any load and fatigue after bending and extending elbow joints to uphold a 5 kg dumbbell.However,the observed arm kept weighing a 4 kg dumbbell with 90 degrees elbow flexion until the muscles were exhausted.The surface electromyography of biceps brachii and triceps brachii of the observed arms was measured using the ME6000.And the integrated surface electromyography (IEMG),root of mean square (RMS),mean power frequency (MPF)and median frequency (MF)were further analyzed.Results The IEMG and RMS of biceps brachii and triceps brachii of the observed arms increased gradually after the exercise began (P＜0.05)regardless of in the relaxed state or in the in the state of weighing a 5 kg dumbbell for the weighted arm,but in the state of weighting a 5 kg dumbbell the IEMG and RMS increased more significantly (P＜0.01),Meanwhile the electrical activities of the triceps brachii as an antagonistic muscle were intensively inhibited.The changes of MPF and MF of biceps brachii in the observed arms were more significant in the state of exercise fatigue than in the relaxed state (P＜0.01),but without such an impact on the triceps brachii.Conclusions The fatigue in one arm can trigger contingent changes in sEMG time domain and frequency domain indexes of its contralateral parallel muscles,suggesting that sEMG changes of upper limb proximal muscles have the co-activation effect.

Antibodies, Monoclonal, Humanized ; administration & dosage ; Antineoplastic Combined Chemotherapy Protocols ; therapeutic use ; Bevacizumab ; Capecitabine ; Chemotherapy, Adjuvant ; Colonic Neoplasms ; drug therapy ; surgery ; Deoxycytidine ; administration & dosage ; analogs & derivatives ; therapeutic use ; Disease-Free Survival ; Fluorouracil ; administration & dosage ; analogs & derivatives ; therapeutic use ; Humans ; Leucovorin ; administration & dosage ; Organoplatinum Compounds ; administration & dosage ; Semustine ; therapeutic use ; Survival Rate ; Vincristine ; therapeutic use

Congresses as Topic ; Humans ; Hypersensitivity, Immediate ; immunology ; Rhinitis ; immunology

Incidence and mortality of colorectal cancer has increased significantly in recent years. Screening for colorectal cancer is the most effective method to decrease mortality. Colorectal adenoma is the precancerous lesion of colorectal cancer and can be detected through colonoscopy, which is the crucial in the early diagnosis and early treatment for colorectal cancer. The first step of screening is the selection of target population and the second step is colorectal examination. The selection of candidate for screening has direct effect on the efficacy of screening. The methods in common use include fecal occult blood test, questionnaire for high risk factors of colorectal cancer, colonoscopy, sigmoidoscopy, and CT virtual colonoscopy. Among those, colonoscopy is the most reliable method and widely used in the screening for colorectal cancer.
China ; Colonoscopy ; Colorectal Neoplasms ; diagnosis ; Early Detection of Cancer ; methods ; Humans ; Mass Screening ; methods ; Occult Blood

MiR-200 family is a cluster of miRNAs closely linked to EMT. The miR-200 family contains miR-200a, miR-200b, miR-200c, miR-141 and miR-429. Many studies have shown that miR-200 family are key regulators of EMT and determine the epithelial phenotype. They are important to both EMT development and tumor progression. This paper reviews the advancement in the research of miR-200 family and its mechanism.

ObjectiveTo compare of the thickness of left ventricular wall of Ang Ⅱ induced cardiac hypertrophy model in both TR3 konock-out C57BL/6 mice (TR3-/- mice) and wild type C57BL/6 mice (TR3+/+ mice) by high frequency ultrasound,combined with experimental research to discuss if TR3 take part in the process of cardiac hypertrophy.Methods26 TR3 -/- mice and 33 TR3 +/+ mice were randomized to 2 groups respectively:TR3+/+ + AngⅡ group (27 mice),TR3+/+ + PBS group(6 mice),TR3-/- + Ang Ⅱ group(20 mice),TR3-/- + PBS group(6 mice).Micro-pumps with AngⅡ or PBS were placed into the subcutaneous tissue of mice to construct hypertension model in 4 weeks.Interventricular septum enddiastolic thickness (IVSd) and left ventricular posterior wall end-diastolic thickness (LVPWd) were measured by echocardiography 2 days before operation and every week after operation until 4 weeks.Then,mice were killed and mice cardiomyocytes were isolated and detected in lab (HE dyeing test,Western blotting).Results①Echocardiography:before operation,IVSd and LVPWd was not statistically different between TR3+/+ group and TR3-/- group( P ＞0.05).1 - 2 weeks after operation,IVSd and LVPWd had peaked in both TR3-/- + Ang Ⅱ group and TR3 +/+ + Ang Ⅱ group,IVSd and LVPWd in TR3 +/+ + Ang Ⅱgroup were significantly thicker than control group (TR3 +/+ + PBS group) ( P ＜0.05),IVSd and LVPWd in TR3-/-+ AngⅡ group were slightly thicker than control group (TR3-/- + PBS group) ( P ＜0.05).Compared with TR3-/- + Ang Ⅱ group,IVSd and LVPWd in TR3+/+ + Ang Ⅱ group were markedly increased( P ＜0.05).After 4 weeks operation,IVSd and LVPWd of all 4 groups were not statistically different than that in the 2nd week.②HE dyeing test:The cell size of cardiomyocytes in TR3+/+ mice increased significantly after Ang Ⅱ treatment,while TR3-/- mice did not.③ Western blotting:Ang Ⅱ promoted TR3 expressions in TR3 +/+ mice( P ＜0.05).ConclusionsTR3 do take part in the process of Ang Ⅱ induced cardiac hypertrophy in mice and it is a key factor in this process.

ObjectiveTo investigate the clinical epidemiologic characteristics of chronic subdural hematoma and risk factors for its recurrence so as to offer scientific basis for treatment and prognostic evaluation. MethodsA retrospective study was done on clinical data of 150 adults with chronic subdural hematoma from the Traumatic Brain Injury Database of Neurosurgery Department of General Hospital of Tianjin Medical University to analyze the clinical characteristics and the postoperative recurrence factors of the chronic subdural hematoma.ResultsHematoma volume of the patients in the recurrence group was more than that in the non-recurrence group.Age ＞ 80 years and brain atrophy were two independent risk factors for postoperative recurrence of the chronic subdural hematoma.The recurrence rate was declined with the decrease of hematoma density on CT.The recurrence rate of the chronic subdural hematoma in the high-density group was significantly higher than that in the low-and iso-density groups. ConclusionsPreoperative hematoma volume,onset age,brain atrophy and hematoma density on CT are significantly correlated with the postoperative recurrence of the chronic subdural hematoma.A detailed clinical and radiological evaluation is of great importance for the treatment and prognostic evaluation of the chronic subdural hematoma.

Objective To explore the effect of cryotherapy and compression system in rehabilitation treatment for reconstruction of anterior cruciate ligament.Methods One hundred and twenty patients who had been treated with reconstruction of anterior cruciate ligament were randomly divided into treatment group (60 patients,treated with cryotherapy and compression system) and control group (60 patients,treated with traditional method).All patients was treated for 3 months and followed up for 6 months.The scores of visual analogue scales(VAS),degree of swelling,Lysholm and IKDC scores were observed and compared.Results The scores of VAS in treatment group postoperative 6,24 and 48 h were significantly lower than those in control group (P ＜ 0.01).The degree of swelling in two groups postoperative 6 h,12 h,24 h,48 h,1 week,2 weeks had significant difference(P ＜ 0.05).The degree of swelling in treatment group postoperative 4 weeks,3 months and 6 months was lower than that in control group,but there was no significant difference (P ＞0.05).The scores of Lysholm and IKDC in treatment group postoperative 4 weeks were (65.2 ± 12.3),(65.3 ± 14.3) scores,in control group were (60.2 ± 12.5),(59.4 ± 13.5) scores,there was significant difference (P ＜0.05).The scores of Lysholm and IKDC in two groups postoperative 3,6 months hod no significant difference (P ＞ 0.05).Conclusion The cryotherapy and compression system in rehabilitation treatment for reconstruction of anterior cruciate ligament can improve the effect of early-term rehabilitation training,but has little impact on the long-term rehabilitation training.

Objective To analyze the relationship between plasma copeptin level and prognosis in patients with severe acute pancreatitis(SAP).Methods The clinical data of 48 SAP patients from January 2010 to October 2014 were collected and another 48 patients who accepted healthexamination dur-ing the same period were selected as controls.Difference in plasma copeptin level was compared between groups.The results of APACHEⅡ,Ranson and modified Marshall scores were also collected to evaluate the severity of disease and the existence of MODS.The prevalence of pancreas and peripancreatic tissues effusion,necrosis,pancreas and peripancreatic abscess,pancreatic pseudocyst and mortality of the experi-mental group were recorded to analyze the relationship among plasma copeptin,complications and mortali-ty.Results The plasma level of copeptin of the experimental group was 0.83 ~5.49ng/ml,with a mean of(3.48 ±1.32)ng/ml;while in the control group,it was 0.09 ~1.46ng/ml,with a mean of(0.23 ± 0.06)ng/ml.There was significant difference between the groups(P <0.05).Patient with a high plasma copeptin level may have a higher risk for local complication,MODS and mortality,and there was significant difference between the groups(P <0.05).A ROC curve identified that a plasma copeptin level >4.02 ng/mL predicted in-hospital mortality of patients,with a sensitivity of 72.7%and a specificity of 81.0%(AUC =0.831,95%CI =1.051 ~1.679,P <0.001).Conclusion SAP patients have elevated levels of plasma copeptin,and higher copeptin levels predict high risks of complications and mortality.

Unlike modern large differences between Chinese and Western medicine , in the early stage of hu-man development , the ancient Greek medicine and ancient Chinese medicine during their exploration has a remark-ably consistent .They all represent the most wisdom philosophy , and good tradition a doctor should have , and thus formed the medical ethics that affect later generations .We can see segment of a whole from the theoretical system between the earliest Chinese medical Inner Canon of Yellow Emperor which formed in the spring and autumn period and the warring states period and Hippocratic Corpus which is on behalf of the 5th century BC to the 2nd century BC, the ancient Greek medicine highest achievement .But since then , Chinese traditional medicine and Western medicine have achieved the last collision , And around the second century AD completely broke ranks .We have to seek the origins from the two kinds of heterogeneous soil China and ancient Greece .Research of the relationship be-tween the period of medicine and philosophy can help us find beneficial enlightenment for the difference .