Objective To explore the effect of brain derived neurotrophic factor(BDNF) on the birth weight and the brain weight of newborn rats with intrauterine growth retardation(IUGR).Methods Female and male Sprague-Dawley rats were mated together and the vaginal plug formation after mating was for pregnancy diagnosis.The day when the plug was observed was considered day 1 of gestation.Then,the pregnant rats were divided into IUGR group and sham surgery group.On day 17 of gestation,the uterine arteries of pregnant rats in IUGR group were clamped for 30 min by blood vessel forceps after abdominal cavity with clamping blood uessels was opened.The pegnant rats in sham surgery group only had abdominal cavity opened without clamping blood vessels.Then the pegnant rats in IUGR group received 9 g/L saline(IUGR group) or BDNF 1 ?g injected in the rat through caudal veins for 5 days after surgery(BDNF intervention group).After vaginal birth,the weight of newborn rats and their brain weigh were measured and analyzed.Results Compared with the sham surgery group,the birth weight and brain weight of IUGR group group rats decreased by 24.9% and 17.3%,respectively,the results were significant(Pa

Objective To explore the change of activin A(ACT A) in umbilical artery blood of newborns with fetal distress and its clinical significance.Methods Forty healthy pregnant women(control group)and 35 pregnant women with fetal distress (experimental group)were collected.The levels of ACT A of umbilical artery blood in both groups were determined by a solid quantitative biotin-avidin system enzyme-linked immunosorbent assay(BAS-ELISA),umbilical artery blood gas were also measured.Results The level of ACT A of umbilical artery blood in fetal distress group was (1 235.89?178.78)ng/L,and that in control group was (627.28?75.24)ng/L,and the level of ACT A of umbilical artery blood in fetal distress group was significantly higher than that in control group(P

Objective To observe the efficacy of 810 nm diode laser therapy for keratosis follicularis.Methods A total of forty-eight patients with keratosis follicularis were treated by 810 nm diode laser,energy range from 9 to 10 J/cm2,frequency 10 Hz,pulse width 400 ms.Treatments were carried out in three times at 8-week intervals,and clinical efficacy was evaluated after third treatment (6 months).Results The total effective rates of keratosis follicularis were 91.7％.With the increase of the number the curative effect were obviously improved.The treatment effective rate was 52.1％ (25/48) for the first time.The treatment effective rate was 75.0％ (36/48) for the second time.And the third time was 91.7％ (44/48).the patients skin texture was obviously improved in the six-month of follow-up except adverse reaction appeared in five patients in the short term.Conclusions 810 nm diode laser is safe and effective for keratosis follicularis.

The anti-tumor effects of Chinese herbal medicines and their prescription preparations attracted more and more attention at home and abroad. Thus, it is becoming a hot research topic to exploit the anti-tumor mechanisms of Chinese medicine, and some of them have been partly clarified with the improved research ability to date. In brief, the Chinese herbal medicines possess unique advantages on the treatment of tumors through their multiple actions on multiple targets.
Animals ; Antineoplastic Agents ; pharmacology ; therapeutic use ; Apoptosis ; drug effects ; Cell Differentiation ; drug effects ; Drugs, Chinese Herbal ; pharmacology ; therapeutic use ; Humans ; Medicine, Chinese Traditional ; methods ; trends ; Neoplasms ; therapy ; Research ; trends ; Signal Transduction ; drug effects

OBJECTIVETo explore the effect of surgical treatment on complex acetabular fractures.

METHODSThe data of 46 patients (38 males and 8 females, aged 16-75 years, mean equal to 38.5 years) with complex acetabular fractures, who were admitted to our hospital from January 1998 to December 2005, were analyzed retrospectively in this study. According to Letournel rules, posterior wall and posterior column fractures were found in 11 patients, transverse and posterior wall fractures in 13, T-type fracture in 4, both columns fracture in 10, and anterior column and posterior transverse fracture in 8. The choice of surgical approach was based on the individual fractures, which included ilioinguinal approach in 5 patients, Kocher-Langenbech approach in 7, combined approach in 26, and extended iliofemoral approach in 8.

RESULTSAll the patients were followed up for 3.5 years averagely. The clinical outcomes were analyzed with Harris hip score and radiography. In 36 patients (78.3%), the surgical procedure was successful (Harris hip score more than 80 points). The rate of excellent and good was about 86%.

CONCLUSIONSThe keys to increase the effectiveness of surgical treatment on acetabular fractures are correct preoperative classification of fractures and choices of appropriate surgical approach and time.

Acetabulum ; injuries ; surgery ; Adolescent ; Adult ; Aged ; Female ; Fractures, Bone ; classification ; surgery ; Humans ; Male ; Middle Aged ; Orthopedic Procedures ; Postoperative Complications ; etiology ; Retrospective Studies

Objective To investigate the association between the tumour necrosis factor-α-863(TNF-α-863) polymorphism and gout in Han population from the city of Tangshan.Methods We recruited 80 gout patients and 80 healthy individuals into this study.The polymorphisms of TNF-α-863 site were analyzed by polymerase chain reaction-ligase detection reaction(PCR-LDR).The frequencies of different TNF-α-863 genotypes/alleles were analyzed in the gout group and the control subjects.Results No significant differences were observed in the genotype frequencies(x2=2.8807,P=0.0897) and allelic frequencies(x2=4.2646,P=0.1187) of TNF-α-863 site in the comparison between gout and control groups.Conclusion The result of our study suggests that the polymorphism of TNF-α-863 site may not related to gout in Han population in Tangshan.

Objective To study the expressions of foliate binding protein 1(Folbp1),Wnt and ?-catenin genes on the heart of offspring during the development of embryo,whose mother was deficient of folic acid.Methods Control group involving 18 rats and study group involving 18 rats were choosen from the total 36 adult female SD rats randomly copulate with the male normal rats after feeding different fodder for 2 weeks.The heart of the 13.5,17.5 days embryos and the newborns were obtained.The expressions of Folbp1,Wnt and ?-catenin genes mRNA at the 3 periods were evaluated by RT-PCR.Results The expressions of Folbp1,Wnt and ?-catenin genes mRNA of the study group were significantly weaker than those of the control group in heart of the 13.5,17.5 days embryos and the newborns(all P

Objective To explore the nursing and effect of massage on head,facial and limbs jointing electrical stimulation method on the therapy for spastic cerebral palsy children.Methods The table of random number was used and forty-two spastic cerebral palsy children were divided into control group( n=19 cases)and treatment group( n=23 cases).conventional rehabilitation training and medical therapy were adopted in control group,on this basic,massage on head,facial and limbs jointing electrical stimulation method and rehabilitation nursing care guidelines were adopted in treatment group.Development screening test method (DST)was used to tested Intelligence index (kT)and Development business (DQ),Gross motor function test scale (GMFM)was also used,then effects of therapy was compared.Results The score of MT、DQ and GMFMin treatment group after received therapy respectively was(79.28 ±2.20),(73.44 ± 1.21 ),(36.25 ±4.66),respectively,higher than that (71.24 ±2.22),(65.07 ±2.54),(23.14 ±4.41 ) before therapy,and the difference was statistically significant(t=- 13.57,- 17.96,8.82,respectively;P ＜ 0.01 ),then compared with scores in control group received therapy that was(72.14 ± 2.09 ),( 68.24 ± 1.98 ),( 28.65 ± 4.85 ),the difference was statistically significant( t=8.04,7.85,3.84,respectively; P ＜ 0.01 ).There was no significant difference on the MT、DQ score in control group before and after received therapy ( P ＞ 0.05 ).The effective rate of therapy in treatment group was 69.67％ higher than that of control group 36.84％,and the difference was statistically significant ( x2=4.497,P ＜ 0.05 ).Conclusions The therapy method of massage on head,facial and limbs jointing electrical stimulation is an effective treatment for spastic cerebral palsy children and worthy of clinical use.

Objective To evaluate the use of gated SPECT in patients with hypertrophic obstructive cardiomyopathy (HOCM) and the effects of percutaneous transluminal septal myocardial ablation (PTSMA) on myocardial perfusion.Methods 99 Tcm-methoxyisobutylisonitrile (MIBI) and 18F-fluorodeoxyglucose (FDG) images were performed in 31 HOCM patients before PFSMA and in 15 patients 3-7 d after PTSMA.The images in different left ventricular segments were analysed by using scores.Results In 99Tcm-MIBI images, uptake decreased at the septal regions in 12 HOCM patients (80.0%, 12/15) after PTSMA, 18F-FDG images also showed decreased uptake at the septal regions in 5 HOCM patients (33.3%, 5/15) after PTSMA.Conclusion 99Tcm-MIBI images might be an important method to evaluate PTSMA results, and 18 F-FDG images showed important value as reference.

OBJECTIVETo investigate the common nasal bleeding points and the management of intractable epistaxis.

METHODSThe bleeding points and its correlation with age distribution, surgical techniques as well as its effects were studied retrospectively in 92 patients, in whom the bleeding points were not found by routine nasal endoscopy and the hemorrhage was not controlled with standard nasal packing.

RESULTSThe bleeding points were found in the following different sites: superior wall of inferior nasal meatus (56.5%, 52/92), olfactory cleft of nasal septum (27.2%, 25/92), posterosuperior wall of middle nasal meatus (8.7%, 8/92) and uncertain (7.6%, 7/92). The results showed that the bleeding points had correlation with age. Epistaxis was well controlled by electrocoagulation in 83 cases, gelfoam packing in 8 cases, and transcatheter maxillary artery embolization in 1 case. There were no complications during a followed-up for 1 - 3 months after management. Among the 92 cases, the numbers of treatment needed to stop bleeding were 82 cases (89.1%) after 1 time of treatment, 9 cases (9.8%) after 2 times and in one case (1.1%) after 4 times.

CONCLUSIONSEndoscopy combined with displacement of the middle and inferior turbinate gives good visualization and direct management of the deeply-sited bleeding points, which were difficult in localization. The combined method provides an effective and safe way to control intractable epistaxis.

Adolescent ; Adult ; Aged ; Electrocoagulation ; Endoscopy ; Epistaxis ; diagnosis ; pathology ; therapy ; Female ; Humans ; Male ; Middle Aged ; Treatment Outcome ; Young Adult