Objective To explore the relationship between serum hs -CRP,IL -17 levels and senium type 2 diabetic macrovascular complications and its clinical significance.Methods The serum levels of hs -CRP and IL-17 were measured with immunoturbidimetry and ELISA respectively in 80 cases of type 2 diabetic patients with macrovascular complications,80 cases of the absence of any major vascular complications in patients with type 2 diabetes and 80 healthy subjects as the control.Results The serum hs -CRP and IL -17 levels of senium type 2 diabetic Patients with macrovascular complications were significantly higher than those of patients without macrovascular complication and healthy control group(t =19.18,23.14,all P <0.01);And serum hs -CRP and IL -17 levels of seniumtype 2 diabetic patients without macrovascular complications were also significantly higher than those of the healthy control group (t =23.64,19.97,all P <0.05 );While serum hs -CRP and IL -17 levels in different subgroup of type 2 diabetic patients with macrovascular complications were no significantly statistical significance(F =1.08,1.49,all P >0.05);In patients of type 2 diabetic Patients with macrovascular complications,hs -CRP was positively correlated with serum IL -17(r =0.712,P <0.05).Conclusion Hs -CRP and IL -17might be involved in the process of inflammatory response to diabetic macroangiopathy,and may have important role in the pathogenesis of senium type 2 diabetic patients with macrovascular complications.Detemination of hs -CRP and IL -17 levels in type 2 diabetic patients may be useful for early detecting diabetic macrovascular complications and serve as the index in monitoring the state of diabetic macrovascular complications.

Select 106 pregnant women with threatened preterm labor between 28 and 37 weeks of gestation. They have been treated continually by the preventing preterm labor therapy including antibiotics and magnesium sulfate. Cervicovaginal fetal fibronectin (fFN) and C-reactive protein (CRP) in serum were detected before treatment and after 3-day and 7-day treatment respectively. 100 normal pregnant women were included as control group. (1) The fFN and CRP had significant differences between study group and control group (P<0.05). (2) The fFN and CPR were different compared in the treatment period (P<0.05). Fetal fibronectin and CRP can be used can be used in therapeutic effect evaluation of threatened preterm labor.
C-Reactive Protein ; analysis ; Female ; Fibronectins ; blood ; Humans ; Infant, Newborn ; Obstetric Labor, Premature ; diagnosis ; prevention & control ; Pregnancy

Pathological changes of Kupffer cells in number and ultrastructure were studied by means of colloidal carbon uptake, endogenous peroxidase cytochemistry, quantitative histology and ultrastructural stereologic morphometry at various time intervals (3,7,14,21,and 28 d) after common bile duct ligation. Kupffer cell phagocytic function and serum fibronectin opsonic activity were measured. The results show the morphological changes of Kupffer cells coinciding with their functional alterations. Alteration of Kupffer cell phagocytic function is mainly due to the changes of number and cellular activity of Kupffer cells.

Objective: To study the lung tissue TLR4 expression and airway hyperresponsiveness(AHR) in the mice infected by respiratory syncytial virus(RSV).Methods:16 clean,6 weeks old BALB/c mice were divided into two groups equally(RSV group and control).One week after RSV infection,AHR was detected by inhaling the increased concentration of methacholine,TLR4 mRNA expression was measured by RT-PCR methods,and the correlation between AHR and TLR4 expression was also analyzed.Results:An important difference was detected in two groups' airway resistance when the inhaled concentration of methacholine was 3.2g/L(P

Objective To discuss the clinical effect of sublingual misoprostol on planned delivery with full-term pregnancy and influence on outcomes of pregnancy and newborns.Methods Ninety-six puerpera with cervical bishop score ≤ 4 were randomly divided into the control group(n =48) and research group (n =48).The patients of the control group were given oxytocin therapy while the research group were given sublingual misoprostol.The promoting effect of cervical maturity,induced abortion effects,outcomes of pregnancy and newborns between the two groups were compared.Results The total effective rate of cervical maturity of research group was obviously higher than that of control group,the differences were statistically significant (91.7％ (44/48) vs 66.7％ (32/48),x2=7.834,P =0.015).The total effective rate of induced abortion effects of research group was obviously higher than that of control group,the differences were statistically significant (93.8％ (45/48) vs 54.2％ (26/48),x2=9.653,P=0.004).The postpartum hemorrhage((183.6±24.2) ml vs.(216.5±32.6) ml,t=6.748),total stageoflabor((7.6±1.3) h vs.(11.3±2.5) h,t=6.636) and cesarean section rate(31.3％ vs.47.9％,x2 =5.637) of research group was obviously lower than that of control group,the differences were statistically significant (P＜0.05).Two groups of newborns and the incidence of neonatal asphyxia,amniotic fluid pollution had no statistically significant difference(P＞0.05).Conclusion The clinical effect of sublingual misoprostol on.planned delivery with full-term pregnancy is obvious and causes little influence on outcomes of pregnancy and newborns.It is safe and effective to be applied on planned delivery and worth popularization and application.

Objective To study the treatment of postoperative pancreatic fistula. Methods The study (retrospectively) reviewed the management of 20 patients with pancreatic fistula. Fifteen patients were treated (conservatively), and 5 patients were treated surgically. Results All of the patients treated conservatively or by (surgery) were cured,and the results were satisfactory. Conclusions The majority of pancreatic fistulas can be cured with conservative management. If the fistula communicates with the main pancreatic duct or fails to heal after 5 months of conservative therapy, operation is necessary.Pancreatic fistulojejunostomy is a simple, safe and effective method.

Objective To study the clinical values of neuron-specific enolase(NSE) as serum tumor marker in lung cancer.Methods The serum NSE levels in 96 patients with lung cancer,60 patients with begnign pulmonary disease and 60 healthy controls were measured by using enzyme-linked immunosorbent assay.Results The levels of NSE in serum in patients with lung cancer was significantly higher than those in healthy subjects and patients with begnign lung disease(P0.05).The effective rate of chemotherapy were 87.10%,40.00% and 66.67%, 33.33% in patients with SCLC and NSCLC,respective for NSE positive and negative ones(P

Objective:To explore the effects of acupoint massage combined with transcranial direct current stimulation on cognitive function and quality of life in patients with spontaneous cerebral hemorrhage, to provide direction for early nursing intervention of patients with spontaneous cerebral hemorrhage.Methods:A total of 214 patients with spontaneous cerebral hemorrhage in First Affiliated Hospital of Zhengzhou University from February 2018 to May 2020 were selected as the research objects. They were divided into 2 groups by random number table method: control group (107 cases) and observation group (107 cases). The control group was given transcranial direct current stimulation intervention, and the observation group was given acupoint massage intervention on the basis of the control group. The intervention lasted for 3 weeks. The intervention effects, cognitive function and quality of life of the two groups were evaluated by National Institutes of Health Stroke Scale, Montreal Cognitive Assessment, Stroke Specific Quality of Life Scale and compared.Results:The total effective rate was 91.59%(98/107) in the observation group, 80.37%(86/107) in the control group, and the difference was statistically significant ( χ2 value was 5.583, P<0.05). There was no significant difference in the cognitive function and quality of life before intervention between the two groups ( P>0.05). The visual space and execution, language, abstraction, delayed recall, orientation and total scores after intervention were (2.54 ± 0.51), (2.35 ± 0.37), (1.96 ± 0.31), (2.78 ± 0.38), (2.88 ± 0.41), (17.48 ± 2.01) points in the observation group, and (2.30 ± 0.62), (2.13 ± 0.36), (1.54 ± 0.38), (2.25 ± 0.43), (2.52 ± 0.38), (15.66 ± 1.89) points in the control group, and the differences were statistically significant ( t values were 3.092-9.554, P<0.05). The energy, family role, mood, personality, language, activities, self-care ability, social role, thinking, upper limb function, vision, work/labor and total scores after intervention were (12.85 ± 2.16), (12.94 ± 3.17), (23.46 ± 3.87), (12.53 ± 3.02), (23.76 ± 4.03), (27.52 ± 4.48), (24.92 ± 3.27), (20.94 ± 4.07), (13.15 ± 2.00), (24.54 ± 4.30), (12.20 ± 2.58), (13.54 ± 2.38), (222.35 ± 24.38) points in the observation group, and (10.04 ± 2.02), (10.52 ± 3.03), (21.25 ± 4.02), (11.15 ± 3.00), (21.46 ± 3.31), (24.37 ± 4.32), (22.38 ± 3.05), (18.60 ± 4.02), (12.47 ± 2.05), (22.08 ± 4.21), (11.42 ± 2.63), (11.05 ± 2.51), (197.49 ± 20.06) points in the control group, and the differences were statistically significant ( t values were 2.190-9.829, P<0.05). Conclusions:Acupoint massage combined with transcranial direct current stimulation can improve the cognitive function and quality of life of patients with spontaneous cerebral hemorrhage, and the effect is definite.

The paper summarized the literature in recent 10 years about the researches on the Idiopathic Pulmonary Fibrosis(IPF) in Traditional Chinese Medicine(TCM). The paper discussed the etiology and pathogenesis of IPF, the experience of famous TCM doctorand the Chinese herbal compound prescription. The discussion could help to clearify the current situation of TCM trestment for IPF.

Howtodevelop promotional strategies ofnetwork teachingplatform in medical colleges has laid a good foundation for the network teaching platform for successful application in medical institutions. These issues are currently facing the construction of digital campus teaching element that must be addressed. Through the research of the promotion process of Chongqing Medical University's network teaching platform,we have described effective promotion strategies of network teaching platform at the "pre-publicity," "functions of the departments," "development of policies and measures",etc.