1.Changes of body mass index and plasma galanin in children with epilepsy following valproate sodium treatment.
Ke-Ling WANG ; Rong-Fu SHI ; Hong-Xia TANG
Chinese Journal of Contemporary Pediatrics 2010;12(6):488-489
Adolescent
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Anticonvulsants
;
therapeutic use
;
Body Mass Index
;
Child
;
Child, Preschool
;
Epilepsy
;
blood
;
drug therapy
;
Female
;
Galanin
;
blood
;
Humans
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Infant
;
Male
;
Valproic Acid
;
blood
;
therapeutic use
3.Changes in Wnt pathway inhibiting factors in nitrosamine-induced esophageal precancerosis lesions and effect of gexia zhuyu decoction.
Wen-Rong SHI ; Yan LIU ; Jin-Dong XIE ; Shi ZHUO ; Chun-Xiang TU ; Zuo-Fu XIE
China Journal of Chinese Materia Medica 2014;39(16):3131-3135
OBJECTIVETo discuss the changes in Wnt pathway inhibiting factors in esophageal precancerosis lesions induced by methyl benzyl nitrosamine (MBNA) and the effect of Gexia Zhuyu decoction.
METHODWistar rats were subcutaneously injected with MBNA (3.5 mg x kg(-1) for twice per week to establish the model. Since the 1st day after the model establishment, they were orally administered with Gexia Zhuyu decoction (16, 8 mg x kg(-1)). At the 10th week, esophageal tissues were collected to observe the pathological changes of esophageal mucosa, detect SFRP1, sFRP4, Axin1, Axin2 and GSK-3β mRNA levels.by fluorescent quantitation PCR analysis and β-catenin protein level by Western blotting.
RESULTBeing induced by MBNA, rats in the model group showed slight atypical hyperplasia in the histopathological examination. Compared with the normal group, Gexia Zhuyu decoction dose high and low groups showed no significant pathomorphological and histological changes. The model group showed lower gene transcription levels of esophageal tissues sFRP1, sFRP4, Axin1 and Axin2 (P < 0.05 or P < 0.01) and higher β-catenin protein expression level (P < 0.01) than the normal control group. The Gexia Zhuyu decoction low dose group showed higher gene transcription levels of esophageal tissues sFRP1, sFRP4, Axin1 and Axin2 (P < 0.05 or P < 0.01) and lower β-catenin protein expression level (P < 0.01) than the normal control group.
CONCLUSIONUp-regulated β-catenin protein level and down-regulated Wnt pathway could enhance Wnt pathway activity of MBNA-induced esophageal precancerous lesions. Gexia Zhuyu decoction could down-regulate the β-catenin protein level and up-regulate the transcription level of Wnt pathway inhibiting factors, but could not block MBNA-induced esophageal precancerosis lesions.
Animals ; Axin Protein ; genetics ; metabolism ; Drugs, Chinese Herbal ; administration & dosage ; Esophageal Diseases ; drug therapy ; genetics ; metabolism ; pathology ; Glycogen Synthase Kinase 3 ; genetics ; metabolism ; Glycogen Synthase Kinase 3 beta ; Humans ; Male ; Necrosis ; Nitrosamines ; adverse effects ; Proteins ; genetics ; metabolism ; Rats ; Rats, Wistar ; Wnt Proteins ; genetics ; metabolism ; Wnt Signaling Pathway ; drug effects
4.Influence of Lamotrigine and Valproate on Cognitive Function in Children with Epilepsy
guan-hui, LI ; rong-fu, SHI ; rong, WANG ; gui-xiang, PANG ; jian-ying, LI ; qing-hua, LI
Journal of Applied Clinical Pediatrics 2004;0(12):-
Objective To explore the influence of lamotrigine(LTG)and valproate(VAP)on cognitive function in children with epilepsy.Methods Seventy-six epileptic children firstly diagnosed were chosen,36 cases received LTG monotherapy and 40 cases undwent the treatment of VPA.The intelligence quotient(IQ)value was measured before and after 6 months treatment respectively,and 20 healthy children were selected as healthy control.Results 1.The epileptic children had poor verbal intelligence quotient(VIQ),performance intelligence quotient(PIQ)and full intelligence quotient(FIQ)compared to the control subjects(Pa0.05).But among the subtestings,the know-ledge,wood-graph,coded score of the VPA groups had significant difference(Pa
5.Quantitative study on depth of ketamine anesthesia for preschoolers
rong-guo, LIU ; wei-fu, LEI ; jin-gui, YU ; jun-zhang, DU ; shi-da, YING
Journal of Applied Clinical Pediatrics 2004;0(11):-
Objective To compare and quantify the determinants in quantitative electroencephalogram(q-EEG) and heart rate variability power spectrum analysis(HRV-PSA) of ketamme(KTM) anesthesia for preschoolers. Methods Seventy four cases were selected and assigned into 3 groups named A(4-5 years), B(5-6 years), C(6-7 years), 22,28,24 cases in every group respectively. All cases were induced with KTM 5 mg /kg intramuscularly and changes of determinants were recorded continuously. If body movement happened, KTM would be injected with 1 mg/kg. Results On pre- anesthesia, BIS in group A was the least among 3 groups, while LF/HF and HRVI were the largest(P
6.Detection of CDX-2, CK7 and CK20 in primary and metastatic ovarian carcinoma.
Zhong-fu YUAN ; Hui-rong SHI ; Hong-min SUN ; Wen-cai LI
Chinese Journal of Pathology 2007;36(8):555-556
Adenocarcinoma
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metabolism
;
secondary
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Adult
;
Aged
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CDX2 Transcription Factor
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Carcinoma, Signet Ring Cell
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metabolism
;
pathology
;
Colonic Neoplasms
;
metabolism
;
pathology
;
Cystadenocarcinoma, Mucinous
;
metabolism
;
pathology
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Cystadenocarcinoma, Serous
;
metabolism
;
pathology
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Diagnosis, Differential
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Female
;
Homeodomain Proteins
;
metabolism
;
Humans
;
Keratin-20
;
metabolism
;
Keratin-7
;
metabolism
;
Middle Aged
;
Ovarian Neoplasms
;
metabolism
;
pathology
;
secondary
;
Trans-Activators
;
metabolism
;
Young Adult
7.Related factors and clinical management of epistaxis in patients irradiated for nasopharyngeal carcinoma
Zichen LI ; Pengfei XU ; Xiaoming RONG ; Xiaolei SHI ; Ruying FU ; Yamei TANG
Chinese Journal of Clinical Oncology 2013;(17):1059-1063
Objective:To explore the clinical measurements for preventing and curing epistaxis in patients irradiated for nasopharyngeal carcinoma by analyzing the related factors. Methods:Thirty patients irradiated for nasopharyngeal carcinoma and consequently presented epistaxis were retrospectively reviewed by analyzing the clinical characteristics and measurements. Literature review was also performed. Results:Twenty-two cases were successfully rescued, and eight cases died (mortality rate:26.6%). Twenty-five cases underwent inflation sponge packing hemostasis, whereas three cases underwent endoscopic hemostasis with cauterization. Five patients underwent digital subtraction angiography (DSA) and selective arterial embolization. For patients who underwent one irradiation course, the epistaxis latent period ranged from 3 to 12 years, and the amount of bleeding ranged from 200 mL to 1 200 mL. For patients who underwent more than one irradiation course, the epistaxis latent period ranged from 6 months to 3 years, and the amount of bleeding ranged from 300 mL to 8 000 mL. Conclusion:Packing through choanal atresia by using inflation sponge, cautery under endoscopy, DSA, and selective arterial embolization are useful and effective measurements for hemostasis. The epistaxis latent period and volume are related to the age, tumor stage, and ir-radiation course of the patients. Patients with advanced age, tumor stage, and more than one irradiation course have short latent period and high amount of bleeding.
8.The Effect of Combination Treatment of Fosinopril and Losartan on Microalbuminuria in Patients with Essential Hypertension
Jing-Wen HUANG ; Ze-Fu YANG ; Shao-Jin LUO ; Shi-Rong XUE ; Ling YANG ;
Chinese Journal of Hypertension 2007;0(06):-
Objective To evaluate the the effect of microalbuminuria of combined treatment with fosinopril and losartan,or fosinopril,losartan monotherapy in patients with hypertension.Methods In this double-blind, intention to treat study,136 patients with hypertension were randomly assigned to receive fosinopril 10 mg/d(n= 50),losartan 50 mg/d(n=41),or a combination of fosinopril 5 mg and losartan 25 mg (n=45) qd for 4 weeks, followed by titrating to the maximum recommended doses for another 4 weeks.The primary endpoint was the difference of mean sitting blood pressure and microalbuminuria excretion at baseline and week 8.Results At week 8,the combination of fosinopril and losartan therapy lowered mean mieroalbuminuria from baseline by 26.1?10~(-8) mol/L,significantly more than either monotherapy approaches (fosinopril 20 mg,18.3?10~(-8)mol/L,P
9.Pharmaceutical Care for a Patient with Anti-N-methyl-D Aspartate Receptor Encephalitis Complicating with Multiple Organ Infections
Lixin ZHANG ; Guobing SHI ; Manman FU ; Rong FAN ; Juan SONG ; Shan JIANG ; Dasheng DANG
China Pharmacy 2015;(23):3294-3296,3297
OBJECTIVE:To explore the methods of clinical pharmacists providing pharmaceutical care for a patient with N-methyl-D-aspartate receptor(NMDAR)encephalitis complicating with multiple organ infections. METHODS:Taking one clinical case as breakthrough point,the points of pharmaceutical care provided by clinical pharmacists for NMDAR encephalitis complicat-ing with multiple organ infections were analyzed,so as to put forward the suggestions in the field of antibiotics selection,medica-tion approach based on pharmacokinetics,ADR disposal and nutrition support. RESULTS:Clinical pharmacists applied pharmaceuti-cal care to resolve ADR as abnormal liver enzyme timely,and the symptom had been improved gradually. Then the patient was dis-charged from the hospital. CONCLUSIONS:Clinical pharmacists provide pharmaceutical care and screen the possible risk of drug use to avoid the occurrence of severe ADR.
10.Surgical treatment of abdominal aortic aneurysms in octogenarians.
Zhen-yu SHI ; Wei-guo FU ; Yu-qi WANG ; Da-qiao GUO ; Fu-zhen CHEN ; Jian-rong YE
Chinese Journal of Surgery 2005;43(7):416-419
OBJECTIVETo evaluate the open surgery as well as the endovascular treatment of abdominal aortic aneurysms (AAA) in octogenarians.
METHODSTwenty AAA cases aging from 80 to 90 in the past six years were reviewed. Open surgery on 12 patients and endovascular repair on the other 8 ones were performed.
RESULTSDuring peri-operation, there were 2 mortality from the surgical group among all 20 cases. The endovascular group underwent significantly better operational procedure and complication situation than the surgical one. Eighteen cases were followed up for 3-69 months (average months) except for 2 patients of surgical group. Both group suffered 2 late mortality. The accumulated survival rate were 6/10 in the surgical group and 6/8 in the endovascular group, respectively.
CONCLUSIONSurgical treatment in applicable for octogenarians with AAA. The endovascular repair was preferable to suitable cases.
Aged, 80 and over ; Aortic Aneurysm, Abdominal ; mortality ; surgery ; Blood Vessel Prosthesis ; Blood Vessel Prosthesis Implantation ; methods ; mortality ; Female ; Follow-Up Studies ; Humans ; Male ; Retrospective Studies ; Stents ; Survival Rate ; Treatment Outcome ; Vascular Surgical Procedures ; methods ; mortality