No abstract available.
Selective Estrogen Receptor Modulators*

No abstract available.
Humans* ; Insulin* ; Receptor, Insulin*

Childhood obesity is a global epidemic, which leads to the increasing number of studies on genetic locations associated with obesity-related traits. Polymorphisms of insulin (INS) gene have been shown to be associated with obesity-related phenotypes in Europeans; while insulin receptor (INSR) gene has been associated with energy regulation. Therefore, this study was conducted to investigate the association between the INS (rs689) and INSR (rs3745551) gene polymorphisms with childhood obesity risk in a Malay childhood population. Normal weight (538) and overweight or obese (557) children aged 6-12 years old were genotyped using semi-automated Sequenom iPLEX® Gold. Body mass index (BMI) was calculated from measured body weight and height. The rs689 (T/T: 0.006, A/T: 0.159 and A/A: 0.835) and rs3745551 (G/G: 0.054, A/G: 0.378 and A/A: 0.568) genotype distributions were consistent with Hardy Weinberg equilibrium. The T-minor allele frequency for rs689 was 8.6% and G-minor allele frequency for rs3745551 was 24.3%. Minor allele of INS gene polymorphisms significantly increased risk of obesity among Malay children (sex- and age-adjusted OR=1.580; 95%CI: 1.134-2.201). However, INSR gene polymorphisms were not significantly associated with childhood obesity. In conclusion, the polymorphisms of INS gene, rather than INSR gene, were associated with childhood obesity in the Malay population.
Pediatric Obesity ; Receptor, Insulin

Endocannabinoids and cannabinoid receptors are expressed in various central pain modulation regions. They maintain in dynamic changes in the expression level and distribution under different pathological and physiological conditions. These changes possess advantage as well as disadvantage. Exogenous administration of endocannabinoids exerts analgesic effect in different pain models, which is mainly mediated by the cannabinoid CB1 and CB2 receptors. Inhibition of enzymes for degrading endocannabinoids in different pain models also shows analgesic effect due to the increased local levels of endocannabinoids.
Endocannabinoids ; Humans ; Neuralgia ; Receptor, Cannabinoid, CB1 ; Receptor, Cannabinoid, CB2

No abstract available.
Interleukin 1 Receptor Antagonist Protein*

No abstract available.
Animals ; Rats* ; Sensory Receptor Cells*

Animals ; Humans ; Ligands ; Polymorphism, Genetic ; Receptor Cross-Talk ; physiology ; Receptor, Angiotensin, Type 1 ; physiology ; Receptor, Angiotensin, Type 2 ; genetics ; physiology

No abstract available.
Epidermal Growth Factor* ; Receptor, Epidermal Growth Factor*

No abstract available.
Kidney Diseases* ; Obesity* ; Toll-Like Receptor 4*

OBJECTIVETo investigate the prognostic association of human epidermal growth factor receptor 2 (HER-2) with resectable gastric cancer.

METHODSThe literature databases, such as PubMed, EMBASE, Cochrane Library, Web of Science, CBM,CNKI, and Wanfang database, were extensively searched to retrieve the clinical studies of HER-2 expression in resectable gastric cancer published before July, 2013. The association of HER-2 expression with overall survival(OS) was examined. The state 12.0 version software was used for meta-analysis. The quality of these studies were assessed using the Newcasthe-Ottawa scale.

RESULTSThere were nine studies meeting the inclusion criteria for meta-analysis including 4787 cases and the scores of all studies are more than 6 points. Meta-analysis showed no significant heterogeneity (I(2)=10.6%, P=0.347) among these studies. There was no significant difference in overall survival between positive HER-2 and negative HER-2 patients (HR=1.16, 95% CI:0.97-1.38, P=0.114).

CONCLUSIONHER-2 overexpression in the tumor is not identified as a significant prognostic factor in patients with resectable gastric cancer.