Objective To study treatment has no risk factors associated with response to treatment with intravenous gamma globulin (IVIG)protein in children with Kawasaki disease,so as to provide basis for clinical early treatment scheme.Methods The clinical data of 187 cases of Kawasaki disease in children were retrospective ana-lyzed.Patients were divided into sensitive group (160 cases)and non sensitive group (27 cases)according to the sensitivity of IVIg treatment,differences in baseline data were compared between the two groups of children admitted to hospital.Related factors were screened by clinical manifestations and logistic regression analysis.Results In chil-dren of non sensitive group,white blood cell count (WBC),neutrophil cell count (N),hemoglobin (HB),C -reac-tive protein (CRP),erythrocyte sedimentation rate (ESR),albumin (ALB),total bilirubin (TB)and immunoglo-bulin (IgG)values were determined respectively of (18.4 ±5.4)×109 /L,(0.72 ±0.16)×109 /L,(99.2 ±11.3)g/L, (108.4 ±43.2)mg/L,(75.5 ±21.8)mm/h,(29.8 ±3.1)g/L,(21.6 ±9.3)μmol/L and (11.8 ±3.4)g/L.The data of sensitive group were (15.1 ±4.3)×109 /L,(0.62 ±0.13)×109 /L,(109.5 ±10.4)g/L,(73.5 ± 41.5)mg/L,(55.3 ±19.4)mm/h,(33.8 ±3.5)g/L,(12.9 ±8.8)μmol/L and (7.6 ±3.5)g/L.The difference between the two groups was statistically significant (t =3.548,3.570,4.701,4.018,4.915,5.578,4.713,5.791,all P <0.05).Logistic regression analysis results showed that ESR (OR =2.083),TB (OR =1.632),CRP (OR =1.592)were three main risk factors of IVIG in the treatment of children with Kawasaki disease,and high Hb (OR =0.743),Alb (OR =0.447)could reduce the risk of IVIG treatment.Conclusion In the first visit,higher WBC,N, CRP,ESRTBand IgG levels may increase the reactive risk of IVIG treatment in children with Kawasaki disease.

ObjectiveTo explore the current occurrence of upper gastrointestinal bleeding in elderly patients in our hospital and its possible risk factors and treatment program.MethodsAn observational prospective analysis of medical records of 758 consecutive patients was performed.Clinical presentation,etiology and treatment were evaluated.The follow-up ended on the dates of a first occurrence of UGIB,stopping co-therapy,death or 6 months after admitted in the group.Results426 male and 332 female were admitted in the group,UGIB occurred in 48 patients.PPI,H2RA,gastric mucosa protectant plus PPI,gastric mucosa protectant plus H2RA and control were prescribed in 108,240,70,102,238 patients respectively.There were statistics difference in each group compared with control in bleeding rate.ConclusionThe occurrence of UGIB associated with A + C co-therapy in elderly was 6.3％.Co-prescription with PPI and gastric mucosa protectant was associated with a lower risk.

OBJECTIVE:To study the effect of surfactants on the pharmaceutical index of sucralfate capsule and to opti?mize its dosage used in the formula.METHODS:The sucralfate capsule was prepared with different surfactants respectively.The disintegration,dissolution and dispersibility of the preparations were determined and their stripping curves were fitted with Weibull distribution model.Different surfactants and the effects of different dosages of which on the dissolution of su?cralfates were compared.RESULT:The sodium lauryl sulphate had the biggest promotion effect on the dissolution of sucral?fate.Optimal indexes of the capsule were achieved when the addition of sodium lauryl sulphate was2%.CONCLUSION:It is advisable to adopt2%sodium lauryl sulphate as the surfactants for the sucralfate capsule.

Through systematical isolation and purification of cellulase from Aspergillus niger using the technique of (NH_4)_2SO_4 fraction ation, gel filtration and ion exchange chromatography, we obtained seven components of endo-?-glucanase (Ⅰ-2a,Ⅰ-2b,Ⅰ-2c, Ⅰ-2d, Ⅱa, Ⅱb, Ⅲa) All of them showed homogeneity in the dise gel electrophresis.

Objective To improve the understanding of X-ray expression of chest in uremia.Methods X- ray expression of chest in 40 cases with uremia were analysed retrospectively.Results 18 eases were interstitial ede- ma of lung,5 cases alveolar edema,17 cases thoracic effusion,32 cases heart image enlargement.Conclusion Chest x-ray film is the convenient and effective method in diagnosis of the chest expression abnormity of uremia and it can guide the clinical treatment of cases with uremia.

Objective To assess the effects of Baclofen plus comprehensive rehabilitation therapy in treating patients with hemiplegic muscle spasticity after cerebral trauma and stroke. Methods Thirty-four patients were divided randomly into two groups. Seventeen patients of therapy group were treated by combining Baclofen and comprehensive rehabilitation therapy, and 17 patients of control group were treated only with comprehensive rehabi-litation therapy. The muscular tension and self-care ability between pretreatment and post-treatment in two groups were assessed by Modified Ashworth Scale and Modified Barthel Index. Results The muscular tension was signi-ficant decreased in patients after treatment ~P

Age-related macular degeneration (AMD) is one of the most important diseases that cause vision loss among older patients in developed countries.As the progress of population aging in China,the incidence of AMD is increasing.The activation of the complement system plays an important role in AMD pathogenesis.Complement factor Ⅰ (CFI) is an important complement regulator.In recent years,there have been numerous studies about CFI single-nucleotide polymorphisms (SNPs) and AMD.The mechanism of CFI and the association between CFI polymorphisms and AMD were reviewed in the article.

Objective To monitor and analyze the use of non-national immunization program(nNIP) vaccines in Fujian Province from 2014 to 2020,and provide a reference for improving the management of nNIP vaccination service.Methods The nNIP vaccination data from 2014 to 2020 were extracted from the National Immunization Program Information System(NIPIS),and analyzed by descriptive epidemiological method.Results From 2014 to 2020,a total of 28 835 834 doses of nNIP vaccines were administered in Fujian Province,with an average of 1 015 doses per 10 000 population,and the varieties used increased from 22 to 28.The annual administered doses of nNIP vaccine,the proportion in total doses of all vaccines and the number of vaccinations per capita basically increased year by year.The most widely used varieties mainly include varicella attenuated live vaccine(VarV),hepatitis B(HepB) vaccine,rabies vaccine(RabV) for human use,haemophilus influenza type b(Hib) polysaccharide conjugate vaccine,influenza vaccine(InfV) and enterovirus 71(EV71)inactivated vaccine.The three vaccines with the highest replacement rates were hepatitis A vaccine,group A meningococcal vaccine and group A and C meningococcal vaccine,with the replacement rates of 22.42%,10.32% and 9.89%respectively.Conclusion There are more and more types and doses of nNIP vaccines used in Fujian Province,so it is necessary to further strengthen monitoring and management and improve vaccination service.

Retinoblastoma(RB) is the most common infant malignant tumor of eye.It seriously affects the life quality and life span.The rapid development of biological technology allows some new breakthroughs in the basic and clinical researches of RB.Current researches focus on its etiology and pathogenesis,and the ultimate aim is to guide clinical prevention,detection and management.Some literature revealed and summarized the histological source of RB,mutation detection of Rb gene,hereditary clue of RB susceptibility,and gene-therapy of RB.Gene therapy of RB is a new treating approach to RB in recent years,and its development brings a chance for achieving the goal of curing RB and improving patient prognosis.The research progress of RB is reviewed here.

Background Selective laser trabeculoplasty (SLT) is one of common therapies for early-stage primary open angle glaucoma (POAG).However,it always been used as a method of treating medically uncontrolled open angle glaucoma in China.So the assessment of efficacy of SLT as the initial therapy for POAG is still lack.Objective This clinical study was to compare the efficacy of SLT in early-stage POAG eyes with or without primary medical therapy.Methods A prospective non-randomized controlled study was designed.Sixty-five eyes of 37 patients with early-stage POAG were divided into without pre-treated group (30 eyes of 16 patients) and with pretreated group (35 eyes of 21 patients).SLT was performed on the inferior trabecular meshwork of 180° in all the patients aged 12-57 years old using a 532 nm frequency-doubled,Q-switched Nd:YAG laser with the pulse 3 ns,spot diameter 400 μm.The emitting energy was set from an initial energy of 0.6 mJ to decreased energy successively at 0.1 mJ interval till bubbles coming out.The following-up was 6 months.Primary outcome of SLT included the changes of intraocular pressure (IOP) and effective rate,and the secondary outcome included the perimetry and C/D value.The safety index was evaluated as the incidence of irritative symptom.Results After SLT 1 day to 6 months,the IOP was lower than that before SLT in all the patients (all at P＜0.05).The IOP was (24.03± 3.76)mmHg and (19.18±3.86)mmHg respectively at preoperation and postoperative 1 month in without pretreated group,with a mean decreasing value of (4.85 ±4.31)mmHg,in with pretreated group,the IOP was (23.63±4.29)mmHg at preoperation and (17.07±4.15)mmHg at postoperative 1 month,with a mean difference of (6.28±3.57)mmHg,with a significant difference in the IOP lowing value between the two groups (P =0.045),but there were no significant differences in the IOP lowing value between without and with pretreated groups in 1 hour,1 day,3 months and 6 months after SLT (all at P＞0.05).The effective rate was 75.00％ and 76.67％ in without and with pretreated groups respectively at the end of following-up (P =0.882).No obvious changes were seen in visual field and C/D value before and after SLT in both groups.Also,no serious complication was found in the patients during the following-up duration.Conclusions SLT has a good outcome in lowing-IOP for early stage POAG.There is no obvious impact to the clinical efficacy of SLT whether with or without the primary administration of anti-glaucomatous eye drops.Long-term effect of SLT remains to be observed.