P-glycoprotein(P-gp),the product of multidrug resistance gene MDR1,plays a very significant role in the ADME processes(absorption,distribution,metabolism,excretion)and drug-drug interaction of drugs in human.The magnitude of resistance depends on the expression of MDR1 up-regulated by chemotherapy.DNA sequence differences ale associated with phenotypic variation by various mechanisms,single-nucleotide polymorphisms(SNPs)is the most common of them.Genetic polymorphisms of MDR1 are associated with alteration in P-gp expression and function in different ethnicities and subjects.

The paper analyzes current situation of the non -medical majors and literature information retrieval course in Traditional Chinese Medicine ( TCM) colleges and universities , points out the course reform objectives and key points .By taking Liaoning Universi-ty of Traditional Chinese Medicine as an example , it discusses the characteristics of non -medical majors and needs for the literature in-formation retrieval course , and proposes the teaching approach of literature information retrieval course for non -medical majors in TCM colleges and universities .

Objective To study the influence of different dosages of atorvastatin in acute coronary syndrome female patients on vascular endothelial growth factor(VEGF) and brain natriuretic peptide(BNP).Methods 60 female cases of ACS patients were divided into A and B group.30 patients in the A group were given atorvastatin 20mg per night,while the other 30 patients in the B group were taken 40mg per night.The patients were followed four weeks by evaluating serum VEGF and BNP concentration.Results After treatment for four weeks,the patients in the two groups showed significant reduction in VEGF and BNP,however,the therapeutic group showed significant difference between the two groups.Additionally,the B group further showed significant reduction in VEGF and BNP.Conclusion Using high-dose atorvastatin lowers VEGF and BNP significantly,which could reduce female cardiovascμlar events.

Objective To find out evidences for the identification of Ajuga decumbens Thunb.(Jinchuangxiaocao) and Pogostemon cablin (Blanco.) Benth.(Guanghuoxiang) . Methods Fresh stems and leaves of the two species were collected and used as the samples. We used stereoscopy to observe and compare the macroscopic appearance of the original plants, and used light microscope to observe the stem cross-section, petiole cross-section, leaf epiderm and powder of the two species for microscopic identification. Results The results of macroscopic character identification showed that the petiole of Jinchuangxiaocao had narrow wing, while that of Guanghuoxiang had no narrow wing; the angles between leaf main vein and lateral vein of Jinchuangxiaocao were less than 45°, while the angles of Guanghuoxiang were more than 45°. In respect of microscopic identification, Jinchuangxiaocao had the glandular scales with multicellular head, and Guanghuoxiang had the glandular scales with one-celled head; the intercellular space and crystals were found in the cortex of Guanghuoxiang stems and mesophyll, while Jinchuangxiaocao has no such structures. Jinchuangxiaocao had diacytic and anomocytic stomata, and Guanghuoxiang only had diacytic stomata. Conclusion The appearance and microscopic differences can be used for the identification of Jinchuangxiaocao from Guanghuoxiang.

[Objective] To provide a basis for the identification of six species of Calicarpa. [Methods] Histological and microhistological features were studied. [Results] Obvious distinctive features of color and types of villi on the back of the leaf were found. [Conclusion] The method can be used to distinguish the features of the six species of Calicarpa.

To summarize clinical experience of Professor HE Tian-you in treating chronic prostatitis with combined acupuncture and herbs.His originally created acupoint ‘san yin xue’as the main points in the acupuncture treatment,and other acupoints were selected according to pattern and symptoms.He emphasized Deqi (acupuncture esthesia) and was good at performing needling manipulation. Based on the main pathogenesis of obstruction of liver liver channel,Prof HE chose Bupleurum chinense,Turmeric Root Tuber,Rhizoma,Szechwan Chinaberry Fruit,litchi,Oldenlandia and spina gleditsiae to compose the main formula.Furthermore,some other herbs were added or subtracted in main formula according to pattern and symptoms.

Objective To find out evidence for the identification of the aerial roots of Ficus microcarpa Linn. f. and F. altissima Bl.. Methods The fresh aerial roots of the two kinds of plants were collected. The appearance traits were observed by stereoscopy. The velamen surface, cross section of root tip, cross section of the posterior root and powder of two kinds of aerial roots were observed under microscope. Results The number of aerial roots of F. microcarpa Linn. f. was more than that of F. altissima Bl., while the diameter was less than that of F. altissima Bl.. Differences were shown in primary xylems of the transverse section of root tip and posterior root of the two kinds of aerial roots, there were 5-7 vascular bundles in F. microcarpa Linn. f. and 7-10 vascular bundles in F. altissima Bl.. As for the powder, the powder of F. microcarpa Linn. f. was yellowish brown, while that of F. altissima Bl. was reddish brown; F. altissima Bl. had more fibers and longer diameter than F. microcarpa Linn. f. and had cluster crystals in order. Conclusion The appearance and microstructure features showed by the results can be used to distinguish the aerial roots of F. microcarpa Linn. f. and F. altissima Bl..

Adult ; Aged ; Aged, 80 and over ; Anti-Infective Agents ; pharmacology ; therapeutic use ; Cross Infection ; drug therapy ; microbiology ; Female ; Hospitalization ; Humans ; Inpatients ; Male ; Middle Aged ; Pneumoconiosis ; microbiology ; Pneumonia ; drug therapy ; microbiology ; Retrospective Studies

Humans ; Occupational Exposure ; Paraquat ; poisoning

Objective To study whether omeprazole induces gastric epithelial cells apoptosis and analyse the possible mechanism. Methods The cell cycle and apoptosis ratio of SGC 7901 cell line were determined by flow cytometry in the presence of omeprazole, meanwhile, TUNEL positive cells from gastric mucosa were counted after incubated with omeprazole for 72 hours. Expression of p53、 GADD 45 、 p15,16,18,19 and bcl 2 were stained by immunohistochemical assay and ATPase activity was tested. Results significant alteration with decreasing percentage of G 1 phase and increasing percentage of G 2 phase of SGC 7901 cell line could be detected after incubating 24 hours with omeprazole at double clinical doses . An apoptosis peak appeared in flow cytometry after incubating 72 hours with omeprazole. However, no genetic products such as p53, GADD 45 , p15,16,18,19 and bcl 2 were seen. Concentrations of ATPase were markedly increased from 0.326 0.387 before incubated with omeprazole to 0.054 0.103 after incubated with omeprazole. TUNEL positive reaction cell counts in fresh mucosa was also increased after incubated with omeprazole for 72 hours( P