Further researches of medical reagents play an important role on increasing therapeutic effect and reducing adverse effect, which are fitted for the emergent requirements of clinical medicine and the development of medical researches and pharmaceutical industry. Extended release preparation may offer the human body with a suitable blood-drug concentration, reduce the administration and obtain the satisfactory efficiency. The profound administration system and treated site broaden the preparation technique of extended release reagents and the development of new preparations. Generally, extended release reagents are prepared to delay the drug release based on the eligible materials, which should be selected according to the influence of physiologic factors on the performance of extended release reagents, such as drug absorption, distribution, metabolism, and time of extended release, etc. There are various kinds of extended release materials, and over 40 varieties have been applied for the current production. This paper is designed to introduce the development of medical extended release materials and the effect of extended release fluorouracil.

Objective To investigate the effect of traumatic brain injury on the expressions of glial cell line-derived neurotrophic factor (GDNF) and its receptors in brain stem of rats.Methods 55 male Sprague-Dawley rats were divided into the normal control group, sham surgery group and injury groups. The rats of injury groups were subjected to Marmarou's closed traumatic brain injury and then were subdivided into 1 h, 2 h, 4 h, 8 h, 12 h, 24 h, 48 h, 72 h and 5 d groups according to the time elapsed after injury. The expressions of GDNF and its receptors (GFRα-1 and Ret) were tested with immunohistochemistry.Results Mild expressions of GDNF and its receptors were observed in brain stem of rats in the normal control group and sham surgery group. The number of GDNF positive neurons reached the peak level at 2 h in brain stem after injury, and that of GFRα-1 and Ret positive neurons reached the peak level at 4 h after injury.Conclusion The expressions of GDNF and its receptors increase significantly at the early time in brain stem of rats after injury. The similar temporal patterns of expressions of GDNF and its receptors are observed in brain stem after brain injury.

Objective To study current situation of creativity among medical students and its influential factors, and to explore structural equation model about influential factors of creativity. Methods The sample was randomly chosen by using cluster-based sampling method, 413 students in medical university were tested by Williams creativity scale and the influential factors of creativity questionnaire. Results Among the medical student's creativity characters, the most extrusive character was challenge(2.35±0.26), the more important were curiosity(2.29±0.28) and risk-taking(2.21±0.27), and imagination(2.04±0.33) was less important. The structural equation model of influential factors of creativity implied that mental health was the most important factor about improving medical student creativity and by changing study style could promote creativity of medical students. Conclusion By establishing structural equation model, we not only study the influential factors of creativity in realistic view, but also master important extent of each influential factors theoretically.

Previous studies have proved that the effect of statins in both primary and secondary prevention of ischemic stroke, however, whether acute ischemic stroke needs to be treated with statins and the effect of statins pretreatment on acute ischemic stroke remain unclear. This article reviews the recent representative studies in this field, and analyzes the effects of the application of statins in the treatment of acute ischemic stroke on prognosis.

Erectile dysfunction was one of the most frequently postoperative complications after radical prostatectomy,which has been deeply concentrated by patients and urologists,along with more and more people were diagnosed as localized prostate cancer.Widely being used for erectile dysfunction after radical prostatectomy,the efficacy and safety of phosphodiesterase type 5 inhibitors have been confirmed by many clinical studies.However,the influences of phosphodiesterase type 5 inhibitors on the occurrence and progression of cancer are still not completely revealed at present.Additionally,the efficiency of phosphodiesterase type 5 inhibitors on biochemical recurrence after radical prostatectomny is still controversial,though it has been demonstrated that phosphodiesterase type 5 inhibitors is not associated with the occunrence of prostate cancer based on recent clinical studies.We will review the possibly mechanisms of phosphodiesterase type 5 inhibitors in oncologic occurrence,especially in the occurrence of prostate cancer and its biochemical recurrence after radical prostatectomy.

Objective To investigate?the?distribution?and?antibiotic?resistance?profile?of?clinical?isolates?in?2015?for?improving?antimicrobial treatment in Chuzhou First Hospital. Methods Bacterial identification and antimicrobial susceptibility testing were?performed?with?MicroScan?WalkAway?96?PLUS?bacterial?identification?system.?All?the?data?were?analyzed?by?WHONET5.6?software. Results A total of 1499 clinical isolates were collected during 2015, of which gram positive organisms and gram negative organisms accounted for 24.7% and 75.3%, respectively. Prevalence of MRSA among S. aureus was 37.0% and MRCNS among CNS 86.3%. All (100%) Staphylococcus and E. faecalis isolates were susceptible to vancomycin, daptomycin and linezolid. About 2.8% of the E. faecium isolates were resistant to vancomycin. All the Streptococcus pneumoniae isolates were penicillin-susceptible, mainly isolated from children. The prevalence of extended-spectrum beta-lactamases (ESBLs) positive strains was 52.9% in E. coli, 30.8% in Klebsiella spp. (K. pneumoniae and K. oxytoca) and 25.0% in P. mirabilis. The ESBLs-positive strains showed higher resistance rate than ESBLs-negative strains to most antibiotics. The percentage of the P. aeruginosa isolates resistant to meropenem and imipenem was all 29.4%. The percentage of the Acinetobacter spp. (A. baumannii accounted for 85.5%) strains resistant to imipenem and meropenem was 63.0% and 64.5%, respectively. Conclusions Antibiotic resistance is still serious in Chuzhou First Hospital in 2015, especially the emerging carbapenem-resistant Enterobacteriaceae, which is of great concern.

Neuroanatomy knowledge is the key to improve the teaching quality of neurosurgery and anatomy teachers' participation in neurosurgery teaching can obviously improve teaching effect. Combined with case-based teaching, we enabled medical students to master the system knowledge from the basic to the clinical , cultivating their clinical thinking ability and the ability to solve clinical problems. Cooperation between clinical medicine teachers and basic medicine teachers can promote the update of knowledge, work out teaching plans together, and improve the quality of teaching.

Objective To investigate the clinical manifestations and imaging features of moyamoya disease (MMD).Method The clinical manifestations and the results of CT angiography ( CTA ) and digital subtraction angiography (DSA) examinations of 162 cases diagnosed with M MD were analyzed retrospectively.Results In 162 patients with MMD, 132 cases (81.48% ) had stroke, in which cerebral infarction and transient ischemic attack (TIA) were 20 cases, intraventricular hemorrhage were 48 cases, cerebral hemorrhage were 52 cases, subarachnoid hemorrhage (SAH) were 10 cases and acute subdural hemorrhage were 2 cases; 8 cases(4.94%) had simple migraine and 22 cases(13.58%) had simple epilepsy.All the patients were with typical imaging findings: ( 1 ) The central branch of the internal carotid artery,bilateral internal carotid artery clinoid segment and proximal arterial stenosis or occlusion was the main performance of MMD.(2) Abnormal vascular network in the skull base was the most feature of MMD changes.(3) The performance of collateral circulation.Conclusions CTA and DSA can be used for the diagnosis of MMD patients.DSA is the gold standard for diagnosis of MMD.

[Abstract ] Objective Ubiquitin carboxyl hydrolase L1(UCH-L1) is a neuron cytoplasm protein and increased UCH-L1 lev-el in cerebrospinal fluid( CSF) indicates brain injury.The study aimed to indentify UCH-L1 level in CSF of patients with subarachnoid hemorrhage(SAH) and assess the prognosis value of UCH-L1. Methods Retrospective analysis was made on 40 aneurismal SAH patients hospitalized in our department from August 2014 to February 2015.In the experiment group, CSF was taken by lumbar punc-ture in day1-day3, day5-day7, and day8-day10 after subarachnoid hemorrhage.In the control group, a single CSF sample was collect-ed during spinal anesthesia before surgery in 10 patients without neurologic disease.ELISA was applied to determine the concentration of UCH-L1 in CSF followed by comparison.Analysis was also made on relationship of the changes of UCH-L1 and modified rankins scale( MRS) 6 months later. Results CSF UCH-L1 concentrations in all SAH patients were significantly increased in day1-day3 ( P<0.05) after SAH, peaked in day5-day7 (P<0.01) and elevated un-til days 8-10 ( P<0.01 ) .MRS at 6 months showed a significant correlation with CSF levels of UCH-L1 in day5-day7 ( correlation co-efficient CC=0.691, P=0.001) and day8-day10 (CC=0.583,P=0.03), but not in days1-day3 (CC=0.364,P=0.08).SAH pa-tients with a good outcome at 6 months ( MRS<4) had much lower UCH-L1 levels in day5-day7 ( P=0.001) and day8-day10 ( P=0.041) than those with a poor outcome (MRS≥4).Higher UCH-L1 level at day5-day7 was a predictive marker of poor outcome in bi-nary logistic regression analysis (P=0.003); Conclusion The study suggests that increased CSF UCH-L1 level in day5-day7 after SAH is correlated with higher MRS and predicts an adverse clinical outcome 6 months after SAH.

Fascin,an actin cross-linking protein found in membrane ruffles,microspikes,and stress fibers,induces membrane protrusions and increase cell motility in various transformed cells.The expression of fascin in epithelial neoplasms has only been described recently,and fascin overexpression may play an important role in the progress of neoplasms.This article reviews the current situation and the up to date progress of study concerning fascin and epithelial neoplasms.