The changes of arginine vasopressin (AVP) levels in plasma in some physiological states in healthy men were studied by RIA. Mean plasma AVP concentration in 30 normal adults after 12 h of overnight water deprivation was 10.6?2.5 pg/ml, and decreased from 11.85?6.0 to 1.8?1.6 pg/ml 1 h after an oral water load (20 ml/kg) administered in 16 dehydrated normal subjects (P

Peking Union Medical College is the earliest college to launch the clinical medicine specialty of 8-year program.The achievements that our college obtains are obvious to all.The education item of admission for 7-year switching to 8-year in the clinical medicine specialty was started to put in practice in 1995 and has been carried out for 12 years.The item has accelerated the flourish of science,facilitated the diversification of students' source and knowledge configuration and brought out a large quantity of high level medical persons with high quality The successful fulfillment of the education item of admission for 7-year switching to 8-year in the clinical medicine specialty has enriched our experiences of running college and explored a new mode of training high level medical persons for adopting to the situation of our country.

In order to meet the needs of increased requirement of nurse especially in the region with limited resources for education and training,PUMC Nursing School initiated a program of Day School Student since 2002. This paper reviews the enrollment,education and training of these students and to share our experience with other schools in China in terms of strategy development and program implementation.

Professional development of faculty is an essential component of strategy for medical schools to construct teaching team.Development of education is dependent upon the professional quality of teaching staff.Starting from connotation of faculty's professionalism,this paper compared present status of composition of teaching staff in China with that in foreign countries,explored the potential approaches for medical schools to strengthen the construction and sustainable development of teaching staff.

Objective To investigate the circumstance of hospital-acquired infection in patients with acute myocardial infarction(AMI),analyse the correlation factors of hospital-acquired infection and guide the clinical treatment in AMI patients.Methods To retrospectively analyse the relation between the incidence rate of hospital-acquired infection and the factors such as sex,age,heart function,position of mycardiac infarction,complication,virulence operation,the use of antibiotics in 254 patients with AMI.Results The factors of advanced age,cardia insufficiency,anterior wall and multitude walls mycardiac infarction,delay visit,chronicity pulmonary disease,diabetes mellitus,virulence operation could increase the incidence rate of hospital-acquired infection(P

0.05),and the Killip classification and LVEF in the period of hospitalization after 24 hours and AMI after 3 months in PTCA group were significantly improved compared with that in no-PCTA group(P

0.05).The effective rates of the two treatment schemes were 90%,87%.The cost effectiveness ratio were 108.61 and 76.35.Conclusion Homemade octreotide is better in the treatment of severe acute pancreatitis.

As antigen-presenting cells, DCs are the most potent and unique,they can stimulate the primitive T cells. They play a major role in initiating the immune response. Tumor infiltrating dendritic cells (TIDCs) can reflect the antitumor immune capability of the host. The density of TIDC perhaps is associated with the prognosis in some cancers. The disablement of TIDCS is partly due to the phenotype they have. Perhaps it is the immunosuppressive factors secreted by tumor cells that have changed their phenotype.The studies about TIDCs provide the basis for DC-mediated antitumor immune therapy,and suggest the use of DC to treat tumors through different approaches.

Arrhythmogenic right ventricular cardiomyopathy(ARVC) is a cardiac muscle disease characterized by peculiar right ventricular involvement that precipitates ventricular arrhythmias and sudden death.ARVC is a major cause of sudden death in the young and athletes.It is familial origin in 50% to 70% of cases,which follows an autosomal in heritance pattern.The pathology consists of a genetically determined dystrophy of the right ventricular myocardium with fibrofatty replacement.Clinical diagnosis can be achieved by demonstrating functional and structural alterations of the right ventricle,depolarization and repolarization abnormalities,arrhythmias with the left bundle branch block and fibro-fatty replacement through endomyocardial biopsy.Clinical research has indicated that successful treatment of ARVC is based on lifestyle modifications,prophylactic therapy(antiarrhythmic drugs,catheter ablation and implantable cardioverter defibrillator)to prevent sudden death.

Objective To explore cephalosporinase from nosocomial Klebsiella pneumoniae infection and their drug-resistant characteristics among the ICU patients so as to provide an instruction for rational clinical medication.Methods 67 samples were identified with VITEK-60 automated system.The strains producing AmpC β-lactamases were screened with cefoxitin disk diffusion method recommended by the CLSI,and confirmed by cefoxitin three-dimensional test.AmpC β-lactamase genotype was differentiated by PCR-sequencing and susceptibility tests which were done with the Kirby-Bauer method recommended by the CLSI.Results In the 67 isolates of Klebsiella pneumoniae,11 strains(16.4％) were found to produce AmpC β-lactamases.The drug-resistant genotype for all the 11 AmpC-positive strains was DHA-1.AmpC-producing strains developed multi-drug resistance,especially for broadspectrum β-lactam antibiotics and enzyme inhibitors.β-lactamases-producing strains were more resistant than non-producing ones.Conclusion Klebsiella pneumoniae in ICU patients has a higher proportion of producing AmpC β-lactamase strains,which are all of DHA-1 genotype and have multi-drug resistance.