ObjectiveTo explore the changes of serum macrophage migration inhibitory factor (MIF),interleukin-6(IL-6),tumor necrosis factor-alpha(TNF- α ) levels,and the relationship with creatine kinase-MB (CK-MB) in children with viral myocarditis induced by coxsackie virus type B,and its clinical significance.MethodsSerum MIF,IL-6 and TNF- α levels were detected by enzyme-linked immunosorbent assay (ELISA) in 58 cases with viral myocarditis induced by coxsackie virus type B in acute phase (viral myocarditis group) and 40 cases hospitalized children (control group).CK-MB was measured by Hitachi 7180 fully automated clinical chemistry analyzer.ResultsSerum MIF,IL-6 and TNF-o levels of viral myocarditis group [ (59.15 ± 25.35 ),(68.52 ± 12.78 ),(85.31 ± 34.18) ng/L] were significantly higher than those of control group [ ( 36.78 ± 12.06 ),( 28.75 ± 16.03 ),( 52.91 ± 14.39 ) ng/L ] (P ＜ 0.01 ),and CK-MB of viral myocarditis group [(46.74 ± 23.89) U/L] was also significantly higher than that of control group [ ( 19.23 ± 11.56 ) U/L ] (P ＜ 0.01 ).There was positive correlation in children with viral myocarditis between MIF,IL-6,TNF- α and CK-MB (r =0.74,0.63,0.69,P ＜ 0.05).ConclusionsIt suggests that immune dysfunction exist in children with viral myocarditis induced by coxsackie virus type B.MIF,IL-6 and TNF- αmight take part in development of myocarditis,and the detection of them can evaluate severity of myocarditis.

Medical English is an important direction of college academic English teaching.This paper taking medical English as an example attempts to explore a new form of MOOC (massive open online courses) based on WeChat platform.With the help of the developer mode provided by the WeChat platform,various interaction and customization are achieved by programming.This kind of course is called WeChat-MOOC.It is introduced into the traditional class combining with the various students' activities,which makes the online and offline,mixed-class mode come true.

Febrile seizure (FS) is the most common type of seizures in infants, toddler, and preschool children. Inlfamma-tory mediators as triggers of fever are considered to be involved in the occurrence of such seizures. There is evidence that FS is accompanied by inlfammation. The potential role of inlfammatory mediators in the development of epilepsy after long term FS has not been fully determined. In this article the inlfammatory reaction, febrile convulsion, and the occurrence of secondary epi-lepsy will be reviewed. The progress in research of the interaction among them at home and abroad will be explored.

Bronchoalveolar lavage ( BAL) has been widely used in pediatric respiratory system disea-ses,and it has been comfirmed the value of the diagnosis and treatment in lung diseases. Collected bronchoalveo-lar lavage fluid ( BALF) is often used in microbiological pathogen identification,cellular and non-cellular com-ponents analyses. And it can be also used as guideline of clinical medication,diagnosis,treatment and pathogene-sis research of the respiratory disorders. This article summarizes the advance of BAL in pediatrics ,such as BAL operating skills,specimen transport and handling,and clinical application in lower respiratory tract infection and interstitial lung disease.

Objective To observe the infecion status and drug resistant rate of mycoplasma in infertility patients in Puyang city and to guide useing drug rationally.Methods A total of 500 women in reproductive period in Puyang city were recruited in this study,collected their vaginal discharge specimen,then cultured and detected ureaplasma urealyticum(Uu) and mycoplasma hominis(Mh) by liquid culture method and solid culture method.The women with positive results were divided as the pregnancy group and infertility group.The sensitivity rate of mycoplasma to 12 kinds of antibiotic were tested.Results The positive rate of mycoplasma in all the 500 women was 44.0%(220/500),the constituent ratio of pregnancy group(60 cases) was 27.3%,and the constituent ratio of infertility group (160 cases) was 72.7%.The difference was statistically significant between infertility group and pregnancy group(P<0.05).The Uu infection rates in pregnancy group and infertility group were 71.6% and 76.2% respectively,and the Mh infection rates were 11.6%,11.2% respectively.The rates of infecting Uu and Mh at the same time were 16.6% and 12.5%.The mycoplasma in and infertility group the pregnancy group were sensitive to spectinomycin,doxycycline and capminocim,which were 91.8%,92.1%,88.3%;90.9%,90.9%,87.3%.Conclusion The infection rate of Uu is higher than Mh in patients with infertility,which is resistant to quinolone classes and large ring lactone class antibiotic.

The rupture of vulnerable carotid atherosclemtic plaques and distal embolization of atherornatous debris are the most important pathogenesis of atherosclerotic stroke.The serolog- ic(and plasma)markers associated with vulnerable plaques will change significantly in this process,and show their different meanings.The studies in this field are in its infancy and still need to be further validated,This article reviews the advances in research on the correlation of these biomakers with vulnerable plaque and ischemic cerebrovascular disease,and briefly intro- duces the clinical application prospect of some of the biomakers.

Adenoma, Pleomorphic ; surgery ; Adult ; Female ; Humans ; Male ; Middle Aged ; Nasopharyngeal Neoplasms ; surgery

No abstract available.
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The attributes of hospital is one of important factors which affect the health service polices and medical practice.the current situation of doctor-patient relationship and frequent doctor-patient dispute was deviate from these attributes.The hospital attributes must return to its nature so as to lessen the contradiction of doctor-patient relationship and decrease the dispute,and use these theories as base to make scientific and rational health polices,and promote the development of our health service.

Objective To assess the efficacy and safety of naloxone for treating cerebral infarction.Methods Randomized controlled trials(RCTs)and quasi-RCTs were identified from MEDLINE(1966-2005.4),EMBASE(1980-2005.4),Cochrane Controlled Trials Register(Cochrane Library issue 2,2005),CBMdisc(1978 -2005.4).We handsearched related published and unpublished data and their references.All naloxone treating for cerebral infarction were included.Data were extracted and evaluated by two reviewers independently with designed extraction form.RevMan 4.2.7 software was used for data analysis.Results Twelve RCTs involving 1075 patients were included.All the results of meta-analysis were listed as follows:(1)Total effective rate:compared with none control,5 studies showed that naloxone had a statistical difference with RR 1.24,95 %CI 1.05 to 1.46;(2)cure rate:compared with none control,naloxone had a statistical differences with RR 1.54,95%CI 1.09 to 2.18;(3)adverse effect:the number of accidence were few and representations were light.Conclusion Naloxone may increase the total effective rate and cure rate of cerebral infarction.More high quality trials are required.