1.Quality standard for Manshanbai Sirup
Chinese Traditional Patent Medicine 1992;0(04):-
AIM: To establish the quality standard for Manshanbai Sirup. METHODS: Rhododendron seniavinii Maxim. was identified by TLC. Quercitrin and hyperoside were determined by HPLC.HPLC conditions were as follows:Hypersil C_18 column,a mobile phase of acetonitrile- 0.05% phosphoric acid (14 ∶86),detection wavelength was at 350 nm. RESULTS: The spots were clear in TLC chromatogram and could be identified easily. The linear range of quercitrin was 0.039 6-0.991 ?g,the average recovery of quercitrin was 99.39% . The linear range of hyperoside was 0.04-1.025 ?g, the average recovery of hyperoside was 97.62% . CONCLUSION: This method is simple, accurate. It can be used for the quality control of Manshanbai Sirup.
2.Genetics and clinical progress of Marfan's syndrome
International Journal of Pediatrics 2010;37(1):59-61
Marfan's syndrome(MFS) is a relatively common autosomal dominant hereditary disorder with prominent manifestations in the skeletal, ocular, and cardiovascular systems. MFS has a high penetrance. Recent research on the pathogenesis and diagnosis and therapy of MFS has made a lot of progress. So we reviewed the advance on the relation of molecular genetics and phenotype of MFS.We discussed the molecular hasis, gene mutation and location, diagnosis, clinical features and therapy. Now the detection on the molecular level has been a very important method in diagnose MFS very early or before bom.
3.Computed tomography diagnosis of xanthogranulomatous cholecystitis
Chinese Journal of Digestive Surgery 2011;10(2):150-152
Xanthogranulomatous cholecystitis (XGC) is benign and chronic, which is rarely seen in clinical practice.The clinical and imaging presentation of XGC is similar to that of chronic cholecystitis, cholecystolithiasis and gallbladder cancer.Summarizing the computed tomography (CT) presentations of XGC is helpful in improving the diagnostic accuracy. According to the result of a retrospective analysis based on the clinical data of 17 patients with XGC, we concluded that rim enhancement sign and hypodense band sign in the arterial phase of contrast enhanced CT, and clear in interface between liver and gallbladder and trimness of internal wall in gallbladder are the CT characteristics of XGC.
4.Diagnosis of intraductal papillary mucinous neoplasm of pancreas by computed tomography
Chinese Journal of Digestive Surgery 2012;11(2):148-150
Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is a rare tumor which has malignant potential.Differentiating IPMN from other cystic lesions of the pancreas is difficult. Its clinical symptoms are nonspecific,including nausea,vomiting,abdominal pain,fever or jaundice,possibly accompanied by hyperamy lasemia of blood and urine.Some patients have acute pancreatitis or chronic cholecystitis.According to the result of a retrospective study on clinical and imaging data of 11 patients with IPMN,we drew a conclusion that cystic dilatation of the main or branch of pancreatic ducts and mural nodules,and cystic dilatation linked with the main pancreatic ducts are the characteristics of IPMN of the pancreas.Computed tomography diagnosis is feasible to provide important information for the diagnosis of IPMN of the pancreas.
5.Advancement and perspective of NF-κB in the research of acute pancreatitis
International Journal of Surgery 2010;37(9):621-624
Acute pancreatitis is acute inflammation due to autodigestion of pancreatic tissue by trypsogen activation, can induce systemic inflammatory reaction,and deteriorate to be nonfunction and fatality. Nuclear factor kappa B seizes the coral position in the development of acute pancreatitis, regulates gene expression of inflammatory factors and immune protein. This article reviews the therapy of pancreatitis on account of NF-κB.
6.The relationship of pregnancy-associated plasma protein-A,osteoprotegerin and endometriosis
Chinese Journal of Postgraduates of Medicine 2009;32(3):32-34
Objective To explore the relationship of pregnancy-associated plasma protein-A (PAPPA),osteoprotegerin (OPG) and endometriosis,so as to apply the new theoretical basis for the etiology of endometriosis.Method PAPP-A and OPG in peritoneal fluid were measured in 25 women with endometriosis(study group) and 25 women with hysteromyoma ablation (control group).Results The levels of PAPP-A and OPG were both higher in peritoneal fluid in study group [(72.3±57.4)U/L and (3.28±2.63) μ g/L]than that in control group [(42.3± 19.7) U/L and (1.73 ±0.45) μ g/L] (P＜0.05).Furthermore,significant correlation was found between the stage of endometriosis and the levels of PAPP-A and OPG in study group (P＜0.05).The concentration of PAPP-A in peritoneal fluid were significantly higher in the secretory phase than the proliferative phase of the menstrual cycle in two groups(P＜0.05) ,and OPG in peritoneal fluid without significant difference(P＞ 0.05).Conclusion PAPP-A and OPG maybe play an important role in the development of endometriosis.
7.Preparation of Stemoninine Orally Disintegrating Tablets
China Pharmacy 2016;27(16):2268-2271
OBJECTIVE:To prepare Stemoninine orally disintegrating tablets,and to optimize its formulation and preparation technology. METHODS:Direct powder compression method was used to prepare Stemoninine orally disintegrating tablets. Using material angle of repose,disintegration time and taste evaluation as index,single factor test was used to screen several factors as bulking agent,disintegrating agent,glidant and flavoring agent;using disintegration time as index,L9(34) orthogonal test was used to optimize the formulation with ratio of MCC+mannitol,PVPP,silica powder and aspartame+stevia as factors. Validation test was also conducted. RESULTS:Optimized formulation was that MCC+mannitol(1∶1)was 50%,PVPP was 20%,silica powder was 2% and aspartame+stevia(10∶1)was 7%. 3 batches of prepared Stemoninine orally disintegrating tablets were smooth in sur-face and good in taste;their disintegrating time was(22.6±2.1)s,and weight variation,hardness,contents were within the speci-fied range (all RSD≤0.97%,n=3). CONCLUSIONS:The formulation and technology of Stemoninine orally disintegrating tab-lets are reasonable,and the quality indexes are all in line with the requirements of orally disintegrating tablets.
8.Investigation and Analysis of Online Pharmacy Pharmacist Service in China
China Pharmacy 2016;27(18):2452-2455
OBJECTIVE:To provide reference for the standardization of online pharmacies pharmacist service. METHODS:Lit-erature research method,online entity investigation method and the method of mysterious customer were adopted to investigate 10 well-known online pharmacies,then described the analysis of current online pharmacies pharmacist service in China. RESULTS:There were 5 online pharmacies showing pharmacist service,but only 1 pharmacy could provide pharmacist registration certificate;on average each online pharmacy was allocated with 1.9 licensed pharmacists;only 2 online pharmacies provided 24 hours of phar-macist service;8 online pharmacies provided more than 2 consulting method;messagebox would pop actively when clicking the“Buy”button in 6 online pharmacies;the correct rate of pharmacist’s guidance was less than 60%,only 20% pharmacists could provide right explanation. CONCLUSIONS:The reasons of the lack of online pharmacies pharmacist service include online pharma-cies imperfect laws and regulations and supervision,lack of licensed pharmacists quantity and quality is not high enough,online pharmacies,pharmacists consulting system is not mature. Online pharmacies can improve relevant laws and regulations,strengthen the government supervision,reasonable and effective use of licensed pharmacists resources,perfect the pharmacist online consult-ing service water system and improve the licensed pharmacists to improve pharmacists service function status.
9.Analysis of Adverse Drug Reactions Reported in 2008 by Our Hospital
China Pharmacy 2005;0(23):-
OBJECTIVE: To analyze the adverse drug reactions(ADR) occurred in our hospital in 2008 and to promote clinical rational and safe medication.METHODS: The ADR case reports submitted by your hospital between Jan.and Dec.in 2008 were described in accordance with the standard set by State ADR Monitoring Center,evaluated about the causal relation,graded,collected and statistically analyzed.RESULTS: 50 kinds of drugs were involved in the 90 ADR cases monitored,leading the list were antibiotics which caused 48(53.33%) suspicious ADR cases,followed by hypotensive drugs and antianginal drugs which induced 11(12.22%) suspicious ADR cases and Chinese medicine preparations which induced 6(6.67%) suspicious ADR cases.The suspected ADR cases induced by intravenous route were most common,accounting for 80.00%(72 cases);lesions of skin and its appendants were most common clinical manifestations of ADR,which accounted for 42.22%(38 cases).CONCLUSION: The incidence of ADR induced by antibiotics was on the high side;therefore,great attention should be given to the rational use of antibiotics.
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