1.Common causes of syncope in children
Chinese Pediatric Emergency Medicine 2010;17(6):485-487
Syncope is a temporary loss of consciousness state caused by the transient cerebral insufficiency,often accompanied by decreased muscle tone and failure in maintaining a certain position. Syncope is a common clinical disease of children,the causes of which include nerve-mediated (reflex) syncope,cerebral vascular disease syncope, psychogenic syncope, cardiac syncope, metabolic syncope, unexplained syncope,etc. Nerve-mediated syncope is the most common cause, and vasovagal syncope is the most common type. Al-though the incidence of cardiogenic syncope is low, but its onset is abrupt and dangerous, which should be payed attention.
2.Study of streptococcus pneumonia capsular polysaccharide antibodies in patients with chronic obstructive pulmonary disease
Chinese Journal of Postgraduates of Medicine 2012;35(28):27-29
ObjectiveTo study streptococcus pneumonia capsular polysaccharide antibodies of patients with chronic obstructive pulmonary disease(COPD) in acute exacerbation and the feasibility of vaccination for patients with COPD.MethodsThe COPD in acute exacerbation without respiratory failure (RF)(COPD without RF group),COPD in acute exacerbation with RF (COPD with RF group),asthma (asthma group),healthy elderly examination(elderly examination group) and healthy youth examination (youth examination group) were selected,and each group had 15 cases.The levels of streptococcus pneumonia capsular polysaccharide antibodies IgG,IgM and IgA were measured in all groups.Results There was no significant difference in IgG among the five groups (P > 0.05 ).The levels of IgM in COPD without RF group and elderly examination group were significantly lower than those in COPD with RF group,asthma group and youth examination group (0.554 ± 0.309 and 0.538 ± 0.327 vs.0.810 ± 0.387,0.887 ± 0.278 and 0.852 ± 0.305,P < 0.05 ).Although the level of IgA in COPD without RF group was significantly lower than that in youth examination group(0.532 ±0.297 vs.0.930 ±0.502,P <0.05),there was no significant difference among the five groups.Conclusion Patients with COPD should inoculate pneumococcal vaccination.
3.The different negative pressure values of the effect on skin graft
Chongqing Medicine 2015;(16):2197-2199
Objective To study the effect of different negative pressure values of negative pressure wound therapy (NPWT) effect on skin graft .Methods Eighty patients were selected ,who underwent chronic wound bed and preparedto treat with skin graft in surgical ward of emergency department in the Second Affiliated Hospital of Chongqing Medical University from January 2012 to July 2012 .Eighty patients were divided into 8 groups ,group A were treated with packing pressure after skin graft ,group B~ H were treated with continuous NPWT ,pressures were -10 ,-20 ,-30 ,-40 ,-50 ,-60 and -70 kPa ,respectively .Whether they were in comfortable situation at second day after surgery were observed .Flap survival area at Seventh day after surgery was meas‐ured .Results The patient comfort ,flap survival area ,wound healing time of group B to H were higher than those of group A (P<0 .05) .Patient comfort tended to decrease with the increasing negative pressure values between -10 - -40 kPa(P<0 .05) .Flap survival area ,healing time of group B ,C were higher than those of group D to F(P<0 .05) .Conclusion Application of NPWT technology in wound ,-10 kPa negative pressure value can not only improve wound blood circulation ,but also ensure patient be comfortable .
4.Concept and characteristics of ecosystem for disciplinary innovation in universities
Chinese Journal of Medical Science Research Management 2010;23(3):150-151,162
The ecosystem for disciplinary innovation is a new mode that facilitates the improvement of various disciplines in universities. This article analysed innovation, ecosystem for innovation as well as ecosystem for discipline, and proposed the concept and characteristics of the ecosystem for disciplinary innovation in universities.
5.Study on connotation construction of research-oriented hospital
Chinese Journal of Medical Science Research Management 2013;(2):81-82,98
This paper summarizes researches about research-oriented hospital,and proposed the concept of research hospitals.The connotation construction of a research hospital is discussed in terms of the quality of medical care,personnel training,scientific research and management capacity.
6.Construction of cooperative innovation model for the subject innovation ecological system
Chinese Journal of Medical Science Research Management 2011;24(2):92-94
Ecological system of subjects innovation is a strategic paradigm proposed by researchers of subjects innovation.In order to achieve efficient knowledge reuse and continuous knowledge innovation,Ecological system of subjects innovation reconstructs,integrates and optimizes the internal and external resource scattered in different subjects,knowledge chains ,knowledge alliances,knowledge clusters.To construct the cooperative innovation model of ecological system of subjects innovation.In this paper,the definition of ecological system of subjects innovation has been given.Then cooperative innovation model has been constructed and ecological system of subjects innovation has been demonstrated through some cases.Cooperative innovation model of ecological system of subjects innovation is composed of the purpose,the partner and the cooperation.Using extended network cooperation model,ecological system of subjects innovation gain the advantages of competition.
7.Application of gene expression profile in tumor radiotherapy
Journal of International Oncology 2008;35(10):756-758
Gene expression profile technology is characterized by high automation, high accuracy and large information volume, which provides a new way for the development of individualized therapies and novel therapeutic targets. Some researches have identified sets of discriminating genes by using gene expression profile technology that can be used for the predietion of response to radiotherapy in human cancers. Some studies also have confirmed the therapeutic tagerts of radiation sensitizer.
8.Genetics and clinical progress of Marfan's syndrome
International Journal of Pediatrics 2010;37(1):59-61
Marfan's syndrome(MFS) is a relatively common autosomal dominant hereditary disorder with prominent manifestations in the skeletal, ocular, and cardiovascular systems. MFS has a high penetrance. Recent research on the pathogenesis and diagnosis and therapy of MFS has made a lot of progress. So we reviewed the advance on the relation of molecular genetics and phenotype of MFS.We discussed the molecular hasis, gene mutation and location, diagnosis, clinical features and therapy. Now the detection on the molecular level has been a very important method in diagnose MFS very early or before bom.
9.Stem cells in optic nerve protection and restoration following injury
Chinese Journal of Tissue Engineering Research 2010;14(23):4367-4370
BACKGROUND: As a specially differentiated central nerve, optic nerve is once injured, retinal neurons are hard to restore and regenerate. As a result, visual function is lost permanently. Currently, an effective clinical treatment is not available. Due to the multi-directional differentiated potential of stem cells, their role in optic nerve protection and restoration following injury is becoming a hot research spot.OBJECTIVE: To review the classification and transplantation of stem cells in optic nerve protection study, as well as roles of stem cells transplantation in optic nerve protection and repair following injury.METHODS: The database of ISI Web of Knowledge platform was searched on computer from February 1994 to April 2009, with the key words "stem cells, optic nerve" in English. In the same way, the database of CNKI from February 1994 to April 2009 was also screened, with the key words "stem cells, optic nerve" in Chinese.RESULTS AND CONCLUSION: A total of 98 literatures related to stem cells in optic nerve protection and restoration after injury are collected, in which 23 papers are Chinese and 75 papers are English. The studies published earlier, repetitively and similarly are removed, and 38 papers which comply with the standards are involved into this review. Stem cells own the potential of self-renew physiologically, as well as potential of repairing the injuries. At present, most of the researches on stem cells in optic nerve protection and restoration after injury are represented in morphosis. How to implant stem cells safely and effectively and how to recover stable visual function still need our efforts. Stem cells derived from skin, peripheral blood, fat and other tissues are convenient to draw materials and are commendable subjects, we should study them deeply to make preferable use.
10.Effect of levocarnitine on maintainance hemodialysis in patients with hypotension
Chinese Journal of Biochemical Pharmaceutics 2016;36(4):83-85
Objective To investigate effect of levocarnitine on maintainance hemodialysis in patients with hypotension.Methods 64 cases with continuous hemodialysis hypotension were randomly divided into control group and treatment group, 32 cases in each group.Patients in the control group were treated with erythropoietin treatment after regular hemodialysis, and the treatment group based on the control group with levocarnitine.Blood pressure, hemoglobin, urea clearance rate, hypotension and changes of C-reactive protein (CRP), arteriovenous fistula occlusion and cardiovascular events incidence were compared after the treatment.Results Compared with before treatment, the incidence of two groups of blood pressure and hemoglobin levels were significantly increased ( P <0.05 ) and CRP levels decreased ( P <0.05 ) , hypotension, arteriovenous fistula occlusion and cardiovascular events rate were decreased (P<0.05); compared with the control group, systolic blood pressure and minimum systolic blood pressure and hemoglobin levels of treatment group were higher (P<0.05) and CRP levels were lower (P<0.05), the incidence of hypotension, arteriovenous fistula occlusion and cardiovascular events were lower (P<0.05), the clinical curative effect was higher (P<0.05).Conclusion Levocarnitine can effectively reduce the occurrence of hypotension in hemodialysis patients continuously, with good clinical efficacy and safety.