Bisphenol A(BPA)is an environmental endocrine disruptor(EDC)that has been shown to be harmful in laboratory animal studies.However,there are relatively few epidemiological studies to prove the relationship between BPA and health effects in human.This review summarizes the epidemiological studies about BPA and children health,analyze the association between BPA exposure and health outcomes,including neonatal birth weight,productive abnormal,neurobehavioral development,wheeze or asthma,early puberty,obesity.

Acute zonal occult outer retinopathy (AZOOR) is a relatively rare ocular disease that is characterized by the rapid loss of one or more zones of outer retinal function.AZOOR usually occurs in young women.AZOOR patients typically present with the sudden onset of photopsia and acute scotomas related to loss of sectors of outer retinal function.Early in the course of AZOOR,funduscopic appearance was often normal;however,most patients developed zones of retinal pigment epithelial atrophy or pigment clumping over time.Changes in electroretinogram (ERG) and persistent visual field defects were usually observed.Optical coherence tomography (OCT) showed that inner segment (IS)/outer segment (OS) regional abnormal changes corresponding to the visual field defect location area,at the same time the morphology and position of the visual field defect and multifocal electroretinogram (mfERG) shown in retinal amplitude density decreased regions coincide.The visual function of some patients can permanently damage.Fundus examination,mfERG and fluorescein angiography (FA),indocyanine green angiography (ICGA),autofluorescence (AF) and frequency domain OCT imaging techniques has an important significance for the diagnosis of AZOOR.Ever since the lack of understanding,AZOOR is often missed or misdiagnosed.In order to improve the understanding of the disease,this paper reviewed the definition,etiology,the epidemiological characteristics,clinical manifestation,classification,diagnosis,differential diagnosis,treatment and prognosis of AZOOR.

Objective To investigate the correlation between blood glucose variability and poor prognosis in diabetes patients with acute stroke. Methods A total of 1 5 5 diabetes patients with acute stroke were divided into glucose variability group(n= 92,GluSD≥1. 4 mmol/L)and non-glucose variability group(n= 63,GluSD<1. 4 mmol/L)according to the GluSD levels. Then,the subjects in glucose variability group were divided into three subgroups according to GluSD levels:the lowest tertile group (GluSD 1. 42~1. 87 mmol/L),the middle tertile group(GluSD 1. 43~2. 32 mmol/L)and the highest tertile group(GluSD 2. 33~2. 87 mmol/L). All patients accepted 72 h CGM after admission. NIHSS score, MoCA scale and Barthel index were used to assess short-term prognosis. Non-conditional logistic regression analysis was used to analyze the risk factors for poor prognosis. Results The levels of FPG [(8. 49± 1. 71 )vs (7. 33 ± 1. 58 )mmol/L],HbA1 c [(8. 61 ± 0. 55 )% vs (7. 14 ± 0. 43 )%]GluAve, GluMAGE,GluGLI and GluCV were higher in glucose variability group than in non-glucose variability group(P<0. 05 or P<0. 01 ). GluAve,GluMAGE,GluGLI and GluCV were higher in the highest tertile group than in the lowest tertile group (P<0. 05 ). With the increase of GluSD level,NIHSS score increased,MoCA score and Barthel index reduced (P<0. 05 ). Multivariate logistic regression analysis showed that age,HbA1 c,GluAve,GluCV and NIHSS score were risk factors for poor prognosis(P<0. 05 or P<0. 01). Conclusion Blood glucose variability is related to poor prognosis in diabetes patients with acute stroke,suggesting that reducing blood glucose fluctuations may be more beneficial to improve outcomes in the treatment of hypoglycemia.

Comparative proteomies is to compare the differential expression of overall protein profiles in different time and space,to identify differential proteins or protein groups on the expression amount,expression level,and modification status and to further investigate the differential proteins and their function.The aim of this paper is to introduce the application of comparative proteomies in coloreetal carcinoma on the level of cell,tissue,and body fluid.

Immune system is the autologous defense system for people to resist disease. Immunotherapy stimulates the immune system to resist disease, including treatment with immunocyte and vaccine. In recent years, the prognosis and survival quality of tumour patients have been greatly improved through cell immunotherapy by immunoregulation and killing directly on tumor. Immunotherapy becomes the hotspot in research.The study of DN Treg cell on immunotherapy will be of vital significance.

Objective To understand Parkinson disease (PD) medication compliance, and analyze its main influencing factors. Methods The questionnaire method was adopted to survey 130 cases of Parkinson disease patients general information, disease, drug, psychological status, social support and so on. Results The two average score of Parkinson patients medication compliance were (2.36 ± 1.16) points and (9.96 ± 2.60) points. Its influencing factors had personal monthly income, medication concept, PD drug adverse reaction,social support, mental state and anxiety disorder. Conclusions Parkinson patients medication compliance behavior overall is good, but these patients who can be in strict accordance with the doctor′s advice has very few. And the influencing factors are in the majority. According to the influencing factors of medication adherence, medical staff should implement targeted medication guide, in order to improve the medication complianceand their quality of life.

In the present paper, antimutagenic mechanisms of hotbed chives, fragrant-flowered garlic and garlic leaves were investigated by the SOS Chromotest The results showed that these vegetables could inhibit the SOS respones induced by temperature (42℃) in E coli GW1060 and GW11M (rec 441 (tif)), but they could not act on SOS network gene expression in E. coli GW2707 (lexA::Tn5), so one of their antimutagenic mechanisms is inhibitory effect on cleavage of lexA by RecA protease. Desmutagenic test results indicate that some aqueous extractions of the three vegatables can inactivate mutagens outside cells.

In order to sum up the antineoplasmic active components of Holothuria, we studied the literatures in recent years. The results showed that Holothuria contained a variety of anti-tumor active ingredient, such as Holothurian Glycosaminoglycan and Holothurin. These anti-tumor active components played important roles in different stages of tumor developmment, progression and metastasis. The discovery of new anti-tumor active ingredients may be helpful for the application of Holothuria in clinical tumor treatment.

In recent years,research on carotid atherosclerosis has turned to the aspect of neovascularization in vulnerable plaques.The evaluation of neovascularization in plaques using contrast-enhanced ultrasonography has become one of the novel technologies to determine the plaque stability.This article reviews the principles of contrast-enhanced ultrasonography and its application in the evaluation of neovascularization in carotid atherosclerotic plaques and vulnerable plaques.