Objective To observe the efficacy and safety of Ginkgo biloba extract combined with Nimodipine on patients with acute cerebral infarction.Methods 106 cases of acute cerebral infarction were randomly divided into two groups(control group and treatment group),the control group was given Nimodipine on the basis of regular treatment,and the treatment group was given Ginkgo biloba extract combined with Nimodipine on the basis of regular treatment.Results The total effective rate of treatment group was higher than that of the control group (x2 =3.62,P ＜0.05),improvement of neurological deficit was better than that of the control group (t =2.57,5.32,all P ＜ 0.05),Plasma TC and TG levels were significantly lower than that of the control group(t =4.23,6.43,all P ＜ 0.05).During treatment,patients had no serious adverse reactions.Conclusion Ginkgo biloba extract and Nimodipine have synergistic effects,the two combined treatment of acute cerebral infarction have significantly effects,which is safe and reliable.

Objective: To study the anti-complementary anthraquinones from Polygonum cuspidatum and their action targets. Methods: The anti-complementary activity-directed isolation was carried out with the hemolysis test as guide. All isolates were evaluated for their in vitro anti-complementary activities. The action targets of the main bioactive constituents were also examined using complement-depleted sera. Results: Ten anthraquinones and three other compounds were isolated from the EtOAc fraction of P. cuspidatum extract, including physcion (1), chrysophanol (2), questin (3), emodin-8-O-β-D-glucoside (4), emodin (5), rhein (6), fallacinol (7), citreorosein (8), xanthorin (9), isorhodoptilometrin (10), 2, 5-dimethyl-7-hydroxychromone (11), 7-hydroxy-4-methoxy-5-methylcoumarin (12), and 5, 7-dihydroxy-1-isobenzofuranone (13). Compounds 9 and 10 were isolated from the the plants of Polygonaceae for the first time, and compound 9 was the alizarin-type anthraquinone first obtained from P. cuspidatum. Compounds 3-9 showed the anti-complementary activity in different degrees, and compound 7 exhibited the most significant activity against the classical and alternative pathway [CH50 = (6 ± 2) μg/mL, AP50 = (50 ± 5) μg/mL]. The study on the preliminary mechanism revealed that compound 4 interacted with C1q, C2, and C9 in complement activation cascade, while compound 7 acted on C1q, C2, C4, and C9. Conclusion: The anthraquinones are main anti-complementary constituents in P. cuspidatum; and fallacinol (7) is a potential complement inhibitor with strong activity and definite targets, which should be further studied in future.

To observe the efficacy of fumigation with Fumigant I formula, a compound traditional Chinese herbal medicine, in treating adjuvant arthritis (AA) in rats and to explore its anti-inflammation mechanism.

Hilar cholangiocarcinoma (HCCA) or Klatskin tumor is a scirrhous adenocarcinoma that arises from the conjunction of bile duct and hepatic ducts.Hepatic magnetic resonance imaging (MRI) and magnetic resonance cholangiopancreatography (MRCP) are important methods for the diagnosis of HCCA.In this article,the clinical data of 42 patients in the Changhai Hospital and 18 patients in the Eastern Hepatobiliary Surgery Hospital who received MRI and MRCP examination from October 2010 to October 2012 were retrospectively analyzed.According to the pathological features,HCCA could be divided into mass-forming type,infiltrating type and intraductal type.Based on the results of imaging examination and intra-and postoperative pathological examination,Bismuth-Corlette types were decided pre-and postoperatively.The coincidence rate of pre-and postoperative Bismuth-Corlette types was 89.7％ (35/39).Infiltration of liver parenchyma was both detected pre-and postoperatively in 19 patients (16 patients were detected by MRI preoperatively),and the sensitivity of MRI was 84.2％ ; vascular invasion was both detected pre-and postoperatively in 10 patients (12 patients were detected by MRI preoperatively),and the sensitivity of MRI was 83.3％ ; hilar and retroperitoneal lymph node metastasis was both detected pre-and postoperatively in 6 patients (4 patients were detected by MRI preoperatively),and the sensitivity of MRI was 66.7％.Combined application of different sequences and techniques of MRI is helpful in the diagnosis,staging and treatment of HCCA.

Objective To research on study attitudes of military medical university undergraduates. Methods The study attitudes of all the undergraduates were investigated and compared in different sorts by using homemade questionnaires. Results The general study attitudes of military medical university undergraduates were good. The undergraduates of different grades had not different study attitudes, neither did the undergraduates of different ages. The undergraduates of different sorts had different attitudes, so did the undergraduates of different genders and different specialties. Concretely, the undergraduates not recruited by Army, the men undergraduates, the undergraduates of long academic-year program and five-year military medico have better study attitudes. Conclusion The general study attitudes of military medical university undergraduates were good but there is still some space to boost. All sorts of steps should be taken to correct their study attitudes and advance their study effects.

Lung cancer is the most common cancer and the leading cause of cancer-related deaths in the world. More than 50 % of advanced NSCLC are diagnosed in patients older than age 65 years. Aging is inextricably associated with decreases in marrow reserve, drug clearance, and lean body mass. Elderly cancer patients often present with medical and physiologic challenges that make the selection of their optimal treatment daunting. This article reviews the progress in diagnosis and treatment of lung cancer in the elderly in recent years.

Objective To observe the therapeutic efficacy of acupuncture plus moxibustion in treating chemoradiotherapy-induced leukopenia in patients with malignant tumors.Method A total of 120 patients with malignant tumors who presentedleukopenia during receiving chemoradiotherapy were randomized into two groups. Sixty cases in the treatment group were intervened by acupuncture plus moxibustion; sixty cases in the control group were intervened by oral administration of Batilol tablets and Leucogen tablets.The peripheral white blood cell (WBC) count in the two groups was detected on treatment day 3, 7, 14, 21, and 28.The clinical efficacies of the two groups were compared.ResultThe WBC started toincreaseafter 1-week treatment in thetreatment group (P<0.05) and the increase was statistically significant after 2-week treatment (P<0.01); in the control group, the WBC started to increase after 2-week treatment (P<0.05)and the increase was statistically significant after 3-week treatment (P<0.01); the effect of increasing WBC was more significant in the treatment group compared to the control group (P<0.05,P<0.01).The total effective rate was 90.0% in the treatment group versus 53.3% in the control group, and the between-group difference was statistically significant (P<0.01).Conclusion Acupuncture plus moxibustion can produce a significant efficacy in treating leukopenia induced by chemoradiotherapy.

Objective To study traditional Chinese herb fumigation and steaming in treating AA model rats and the change of IL-1? in serum and joint, and explore its mechanism. Method Fifty Wistar rats were randomly divided into normal group, model group, aqua group, high dose group, low dose group. Except normal group and the right foot of rats were injected CFA 0.1 mL to make AA model. Aqua group, high dose group and low dose group received steam treatment for 10 days. In the 21st day, the content of IL-1? in serum and the expression level in joint were detected. Results Traditional Chinese herb fumigation and steaming group had notable reduction the IL-1? content in serum and strong positive expression of IL-1? in joint than model group. Conclusion Traditional Chinese herb fumigation and steaming can down-regulate the level of IL-1? in serum and restrain IL-1? expression in joint.

Objective To study the mechanism of toxicity of hexane. Methods SD rats inhaled 15 g/ma n-hexane statically for 8 hours. Results The levels of GSH in whole blood of rats declined significantly (t-test,P＜0. 01). The levels of MDA in serum of rats revealed increasing trend but without statistical significance (t-test,P＞0. 05). The activities of SOD and GSH-Px in liver of rats decreased significantly (t-test,P＜0.01). Conclusion n-Hexane could induce or enhance the reaction of oxygen free radical in organism,and result in damages of lipid peroxidation,which might be one of the mechanisms of the toxicity of alkane.

Bone is the most common site for metastasis from prostate cancer, and bone metastases also is one of the main causes for the death of the patients with prostate cancer. Since the patients with bone metastases from prostate cancer still have relatively long survival periods after treatmemt, how to properly choose the treatment option for the metastatic patients is imperative in terms of improvements in both quality of life and life expectation. This paper summary pathophysiology, risk evaluation clinical assessment and the current status of the treatment options of prostate cancer with bone metastases, it also lays out the background for the individualized treatment plan that still needs to be further investigated.