Gastroesophageal reflux disease( GERD)is a common gastrointestinal disorder during pregnancy. Several factors including decreased lower esophageal sphincter pressure, increased intra-abdominal pressure secondary to the enlarged gravid uterus and alteration in gastrointestinal motility have been linked to the pathogenesis of GERD. Diagnosis and treatment of diseases during pregnancy are unique. Life-style modifications are helpful for the majority of patients. When considering medical therapy,a step-up therapy from antacids,H2 receptor antagonists to proton pump inhibitors should be followed. In patients without a prior history of reflux,symptoms usually are relieved after delivery.

From 2004 to 2005,In order to find the impact on the children`s behavoir in the one parent family, we selected the parents divorced family and the normal family to compare the behavior difference of 5-6 years old children from 45 families ,in them, 19 boys and 31 girls. In group one, 15 families,only the mother take care the children, In group two,15 families, Only the Father take care the children .In group three,only the Grand Parents take care the children, in Group four, we select 15 normal families`s Children. They have the similar ages, after checking in their expression,character and the intelligence, The average score of group1,2and 3 on expression is 138,the score of the group 4 is 195, the different ratio data (P

Objective To introduce a patent: The assembled equipment of external counterpulsation with an oxygen mask in the treatment of ischemic diseases that has been opened by the national property right bureau of knowledge.Methods Based on the current equipment,oxygen was provided with a mask along with external counterpulsation.Results It could enhance blood stream as well as the blood oxygen rate.Conclusion Assembled equipment of external counterpulsation with oxygen mask can enhance cure speed and rate in the treatment of ischemic diseases.

Objective　To investigate the effects of a wide range of concentrations of As2O3 malignant lymphoma cell lines. Methods　Cell apoptosis situation ,cellular DNA contents and bcl-2 protein expression were determined by cell stain, TdT-mediated dUTP Nick-end Labeling (TUNEL) and flow cytometry. Results　0.5 μmol/L～2.0 μmol/L As2O3 could inhibit Raji cell growth accompanied by the appearance of morphologic characteristics of apoptosis. Number of sub-G1 cells significantly increased and bcl-2 protein expression in Raji cells was significantly down-regulated assayed by flow cytometry. The relationship between bcl-2 protein and the concentrations of As2O3 showed a dose-and time-dependent effect; so did the number of sub-G1 cells. However, there was no effect of 0.5 μmol/L～4.0 μmol/L As2O3 on Jurkat cell.Conclusion　It is found that As2O3 could significantly inhibit the growth of B lymphoma cell lines and induce their apoptosis.

Objective To analyze the common and individual training needs of palliative care among nurses in different level hospitals. Methods The self-designed questionnaire about training needs of palliative care was used to investigate 340 nurses in different level hospitals. The data were analyzed by Ridit analysis method. Results There were 24 important items and 26 unimportant items in the common training needs. Regarding the individual training needs,the concept of palliative care,basic nursing care and bereavement support were preferred by the primary-level hospital nurzes,while the principles of palliative care,basic nursing care and pain management in secondary-level hospital nurses,radiotherapy and chemotherapy care and the ethical and moral problems in palliative care in third-level hospital nurses. Conclusion Different level hospital nurs-es have beth common and individual needs in the training contents of palliative care. Ridit analysis can distinguish the differ-ences and provide reference for the training.

Objective: To study clinical significance of endogenous vitamin C 、 E in patients With hypertension and stroke. Methods: The serum vitamin C、 E, Malondialdehyde (MDA), superoxide dismutase (SOD) were determined by ultraviolet spectrophotometry in patients with hypertension (23 cases)、 hypertensive cerebral hemorrhage (CH, 30 cases)、 ischemic cerebrovascular disorders (IC, 25 cases) and control groups (20 cases). Results: Compared with control group, at acute stage of stroke, the Vit C、 E and SOD levels significantly reduced (P＜0. 01), the MDA level significantly increased (P＜0.01); at convalescent stage, the Vit C、 E gradually recover to normal, the SOD still reduced (P＜0.05), the MDA still incresed (P＜0.05). Conclusion: The endogenous Vit C、 E have significant change in patients with acute stage of stroke, it gradually recovers to normal in convalescent stage. Meanwhile the SOD and MDA change accordingly.

ObjectiveTo observe the efficacy and safety of house dust mite vaccine in the treatment of house dust mite-allergic rhinitis.Methods47 patients with allergic rhinitis were recruited into the study.The course of SIT was treated by house dust mite vaccine for 51 weeks.Self-contrast method was used to compare the symptom score,nasal airway resistance before and after treatment.Then we observed the security in the process of injection.ResultsThe symptom score was (7.40 ± 1.64) vs ( 3.40 ± 1.50 ) pre and post therapy.Nasal airway resistance were (2.02 ±0.72) vs ( 1.06 ± 0.81 ) kPa · s -1 · L-1.Both the values of the data had significant differences( t =15.49,4.44,all P ＜ 0.01 ).No serious adverse reaction was observed.ConclusionSIT was able to improve the clinical symptoms and decrease nasal airway resistance.House dust mite vaccine was an effect and safe drug for the dust mite allergic asthma patients.

Objective To investigate the differences of symptoms,physical signs and examinations in childhood and adult patients with Marfan syndrome.Methods Twenty-four children diagnosed as Marfan syndrome were investigated and evaluated synthetically in symptoms,physical signs and examinations.The positive rate of each item was analyzed to find the differences between childhood and adult patients.Results Among 24 patients,thorax and spinal deformity were found in 19 children(79%),leptosome type existed in 16 children(67%),dolichostenomelia was found in 15 children(63%).The dilation of the aortic sinus was detected in 16 children ((67%),)and the dilations of left ventricle and mitral regurgitation were found in 3 children(13%) with echocardiogram.Conclusions It is critical ascertain the abnormalities in cardiovascular system and give intervention,and it is expected to prolong the patients′ life by slowing down the changes in aortic walls.

BACKGROUND:Besides drug therapy, regenerative therapy is now a matter of global interest in treating osteoporosis. Therefore, it is also important to find better candidate cels. OBJECTIVE:To cognize the status of drug therapies for osteoporosis and stem cels as regenerative therapy. METHODS:A computer-based search of PubMed was performed by the first author to retrieve articles relevant to stem cel therapy for osteoporosis published from January 2000 to December 2014. The keywords were osteoporosis, drug therapy, bone regenerative medicine, stem cel therapy, which appeared in the title, abstract or keywords, and the relevant references were also looked up. Articles published recently or in authoritative journals were preferred, and finaly 39 articles were included in result analysis. RESULTS AND CONCLUSION:Yoshikazu Mikami and co-workers from Japan found two novel bone formation accelerators, SST-VEDI and SSH-BMI, which provides a new direction for related studies on drug therapy. Due to the osteogenesis ability, lack of ethical controversy and less damage, de-differentiated fat cels and pulp stem cels may be promising candidate cels for bone regeneration medicine.

Although anterior cervical fusion has been a conventional surgical treatment for cervical spondylosis, concerns for the possible accelerated degeneration of adjacent segments after fusion have been growing. Fusion can also lead to other drawbacks, such as alteration of spinal biomechanics, graft and hardware complications, and chronic pain at the harvest site. In addition, it must be realized that decompression, not fusion, is the primary goal of anterior cervical surgery. Since the artificial cervical disc replacement can preserve enough motion after neural decompression with adequate stability, it provides a new surgical therapy for cervical spondylosis. This paper summarizes the progress in the related research field and makes comments on the current developments and future prospects of cervical arthroplasty.