China ; Communicable Disease Control ; Disease Notification ; Humans ; Population Surveillance

Objective To examine the characteristics of dysfunctional attitudes in patients with so?matoform disorders and to delineate the relationship between dysfunctional attitudes and personality disorder tendency. Methods Sixty?four outpatients with somatoform disorder and 52 healthy individuals were recrui?ted and asked to complete the Personality Diagnostic Questionnaire( PDQ?4) and the Dysfunctional Attitudes Scale( DAS ) for the evaluation of their personality disorder tendency and cognitive characteristics. DAS scores were compared between patient and control groups. The relationship between DAS and PDQ?4 was e?valuated by comparing DAS scores of patients with and without personality disorder tendency and by correla?ting patients’ total scores of DAS and PDQ?4. Results Patients with somatoform disorder(150.13±31.75) showed significantly higher scores of DAS than healthy controls(121.62±20.30). Moreover,patients with per?sonality disorder tendency exhibited significantly higher scores in the total score of DAS and scores of five factors including vulnerability, absorption/exclusive, compulsion, dependence and cognitive philosophy ( P<0.05) . Finally,a positive correlation was found between total scores of DAS and PDQ?4( r=0.535, P<0.01) and the correlation coefficients between the total score of DAS and Cluster A( r=0.545) and C scores( r=0.625) were significantly higher than that of Cluster B score( r=0.317).Conclusion Patients with somato?form disorders have cognitive distortion,which is correlated with personality disorder tendency.

Objective To investigate the relationship between metalloproteinase-9-9 (Matrix),inhibitor-1-1 (MMP-9),metalloproteinase TIMP-1 factor (Matrix) and endothelial growth (VEGF),and to investigate the correlation between the expression of (matrix) and vascular endothelial growth factor (endothelial) and vascular endothelial growth factor (vascular).Methods Sixty-eight cases of non small cell lung cancer patients treated in fengning manchu autonomous county hospital from January to January 2014 were analyzed retrospectively,and the expression level of TIMP-1,VEGF and MMP-9 were analyzed by immunohistochemical method.Results The positive rates of MMP-9 (75％),TIMP-1 (19.12％) and VEGF (13.24％) were significantly higher than those in normal tissues (P＜0.05),MMP-9 (60.87％),VEGF (54.55％),TIMP-1 (65.22％) and VEGF (76.09％,59.09％,63.64％).The positive rates ofTIMP-1,VEGF and MMP-9 were higher than those without lymph node metastasis (P ＜0.05) Conclusion MMP-9,TIMP-1 and VEGF expression levels can predict the invasion and metastasis of non small cell lung cancer,and the three kinds of substances can promote the development and progression of lung cancer in different degrees.

This paper introduces a new method which can judge the degree of burn scar hypertrophy by analyzing chroma of the burn scar. Its technical schedule is as follows: Firstly, the image of the burn scar is captured by using a digital camera. Then the chroma emendation is performed by using an Artificial Neural Network(ANN). At last, the chroma of burn scar is analyzed and the classification of burn scar hypertrophy is given by using a Support Vector Machine(SVM). Compared with clinical evaluation, the result deduced from this method is proved to be effective.

Objective To investigate the clinical characteristics, diagnosis and treatment of acute intestinal perforation in the patients with colorectal carcinoma. Methods The clinical data of 38 colorectal carcinomas complicated with acute intestinal perforation treated in our hospital during 19 years were analyzed retrospectively. Results Acute intestinal perforation was common in old patients with colorectal carcinoma (mean age 62 years).The primary lesions were mostly located in left-side colon and superior rectum(27/38,71.1%). The perforation in the proximal colon of tumor and cecum accounted for 81.6%(31/38), and in tumor site accounted for 18.4%(7/38). The correct rate of preoperative diagnosis was only 15.8%(6/38). The postoperative complications were common and severe. The perioperative mortality was 42.1%(16/38). All the causes of death were multiple organ function deficiency. There were close relations between perioperative mortality and operation time. The postoperative recurrent rate was 41.2%(7/17). Five-year survival rate was 23.5%(4/17). Conclusion Early diagnosis, early operation and active prevention and treatment of multiple organ function deficiency were key to decrease the mortality of the colorectal carcinoma patients with acute intestinal perforation.

Objective To analyse the tongue characteristics of cancer patients during chemotherapy ,in order to guide the TCM treatment. Methods 42 patients' tongue figure was collected respectively before and after chemotherapy by Canon digital camera, then to analyse the characteristics. Results Purple tongue was the most common in tongue color, account for 38.10%;meanwhile the tongue with stasis patch or with toothmark were common in tongue shape, account for respectively 26.19% and 21.43%;white thick or greasy tongue fur was the most common, especially in the central of tongue. Conclusion Deficience of Qi and blood stasis syndrome is common in cancer patients after chemotherapy, it is helpful to provide tasis for treatment of tonifying Qi and activating blood during chemotherapy.

Acute Disease ; Adult ; Humans ; Hydrogen Sulfide ; poisoning ; Male ; Poisoning ; pathology

Child ; Erdheim-Chester Disease ; Female ; Humans

AIM:To detect the expression of miRNA-363 and SOX4 in osteosarcoma tissues and to investigate the effect of miRNA-363 on the viability and apoptosis of human osteosarcoma cell line MG-63.METHODS: Real-time PCR was used to detect the expression level and the relationship of miRNA-363 and SOX4 mRNA in the osteosarcoma tis-sues and the corresponding paratumorous tissues collected from 63 patients.The expression levels of miRNA-363 and SOX4 in osteosarcoma cell line MG-63 after transfected with miRNA-363 mimics were measured .The cell viability was measured by CCK-8 assay.Flow cytometry was used to monitor the changes of cell cycle and apoptosis .The changes of SOX4 and miRNA-363 expression levels in the MG-63 cells after transfection with SOX4 siRNA or pcDNA/SOX4 was detect by real-time PCR.RESULTS:The expressed level of miRNA-363 was lower , and the expression level of SOX 4 was higher in the osteosarcoma tissues than those in the adjacent normal tissues .A significantly negative correlation between the expression levels of miRNA-363 and SOX4 was observed .The expression of miRNA-363 in the MG-63 cells after transfection with miRNA-363 mimics was significantly up-regulated, while the expression of SOX4 in the MG-63 cells was significantly down-regulated , with significant difference as compared with the cells transfected with miRNA-NC and control cells .The viability of MG-63 cells was inhibited, the cell cycle was arrested in G0/G1 phase, and the cell apoptosis was increased by transfec-tion with miRNA-363 mimics.The relative protein expression levels of SOX 4 in SOX4 siRNA group and pcNDA/SOX4 group were significantly different from those in negative control group , but the relative expression levels of miRNA-363 had no significant difference .Over-expression of SOX4 restored the viability of the MG-63 cells reduced by miR-363.CON-CLUSION:The expression level of miRNA-363 is low in human osteosarcoma tissue .miRNA-363 may inhibits the viabili-ty of osteosarcoma cell line MG-63 and promotes cell apoptosis in vitro via inhibiting the SOX4 expression.

Objective To analyze the correlations of clinical characteristics,CT and pathology features of peripheral primitive neuroectrodermal tumors (pPNET)in abdomen-pelvis region,and to improve the understanding of the disease.Methods The clinical information,CT and pathological features of 23 confirmed pPNET patients in abdomen-pelvis region were analyzed retrospectively.Results (1)All patients had preoperative clinical and imaging data integrallty.(2)23 cases showed soft tissue masses with fuzzy boundary and the average diameter were 10.72 cm.Among all,9 cases showed with varying degrees of sac necrosis,while 2 cases showed with platelet hemorrhage and 4 cases with speckled calcifications.Most showed slight-to-moderate heterogeneous enhancement and the necrosis and cystic are-as showed more obvious.12 cases showed with different degree of recurrence,invasion or distant metastasis.5 cases combined with tumor emboli and 4 cases with tumor feeding vessels.(3)Immunohistochemical examination showed CD99 expressed in 1 9 patients, CD56 in 11,vimentin(Vim)in 12,synaptophysin(Syn)in 11,neuron specific enolase(NSE)in 4,FLI-1 in 4 and epithelial membrane antigen (EMA)in 4 patients.Conclusion pPNET is common among young patients with a high degree of malignancy.CT features include large mass with invasive growth,commonly combined heterogenous density,necrosis and cystic changes.Persistent enhancement is observed during nephrographic phase.